Matriz óssea bovina mineralizada na reparação alveolar da mandíbula de cães e sua associação com membrana de colágeno. Estudo experimental

• Autor(a) principal: Fófano, Gisele
• Data de Publicação: 2004
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/4989
• topic: Cão; Ossos; Regeneração; Dogs; Bones; Regeneration; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL::CLINICA CIRURGICA ANIMAL

The periodontal therapies have as objectives not only to stop the progression of the disease, by the interruption of the inflammatory action of the bacterial plate, but also to make possible the restoration of the lost structures, especially as for the maintenance of the architecture and the functional state of those. Thus, the obtained treatments as regenerative or reconstrutivos present as a purpose the formation of new insertion tissues (cement, periodontal linking and alveolar bone) in the involved area by the periodontopaty. Examples of regenerative periodontal therapies include bone grafts and guided tissue regeneration (GTR). The objective of this work was to evaluate the mineralized bovine bone matrix as a substitute bone in the alveolar repairing of the jaw of dogs and its association with a collagen membrane a following the technique of the guided tissue regeneration (GTR). For such, 48 dogs were used, divided in three groups. Defects of approximately 6 x 5 x 5 mm were created among the roots of the fourth right premolar in the vestibular surface of the alveolar bone. In a group, those defects were totally filled out with the xenograft, and in another group, the defect was totally filled out with the xenograft and covered by the membrane, while in the last group, they stayed without treatment, being used as control. Daily clinical evaluations were accomplished for one week, as well as radiographic soon after the surgery and to the 7, 14, 21, 30, 42, 60, 90 and 120 days. The cicatrization of the surgical wound happened in a satisfactory and similar way among the dogs of the three groups. The radiographic exam revealed a slower repairing in the control group, where to the 120 days the defect was still visualized, in comparison with the group treated with the mineralized bovine bone matrix, than to the 60 days was not observed anymore and in comparison with the group treated with the mineralized bovine bone matrix and collagen membrane, than to the 90 days the failure was not visualized anymore. Therefore, it can be concluded that the used materials presented desirable characteristics as biocompatibility and property osteoconductor, being viable alternatives in the aid of the alveolar bone repairing. It was collected, from two animals of each group, material for biopsy of the operated ranch at the 7, 14, 21, 30, 42, 60, 90 and 120 days and histological evaluations were accomplished. In the control group, the bone formation process began at the 14th day and it developed progressively until the 120th day, when the limit between the periphery of the flaw and the new formed bone was not more distinguishable. In the group treated only with the mineralized bovine bone matrix, right at seventh it was observed abundant cellularity around the material and the beginning of the repairing process, that it had already filled out the whole produced defect at the 60 th day. Besides, no reaction of the strange body type was observed and, therefore, it can be concluded that the used material presents desirable characteristics to a substitute bone as biocompatibility and property osteoconductor, being an alternative for the aid of the alveolar bone repairing. In the group treated with the mineralized bovine bone matrix and collagen membrane, a more advanced repairing process was observed in relation to the control group until the 42 th day. Then, a chronic inflammatory process was observed, until the 120 th day, taking it to a repairing bone stagnation. In spite of that, no reaction of the strange body type was observed and, therefore, it can be concluded that the used materials present biocompatibility, desirable characteristic to substitute bone and that the membrane, starting from the 42 th day, provokes undesirable reaction.