Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://doi.org/10.1016/j.lfs.2017.08.014 http://www.locus.ufv.br/handle/123456789/18910 |
Resumo: | Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were submitted to a swimming protocol (1 h/day, 5 times/week, no additional load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical properties. Myocytes were stimulted at frequencies (F) of 1 and 3 Hz at 37 °C. Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR (mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46% to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to sedentary SHR. Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension in male SHR. |
id |
UFV_34c7df8ea82d0d2516baa86426c34daf |
---|---|
oai_identifier_str |
oai:locus.ufv.br:123456789/18910 |
network_acronym_str |
UFV |
network_name_str |
LOCUS Repositório Institucional da UFV |
repository_id_str |
2145 |
spelling |
Locatelli, JamillePaiva, Nívia C.N.Carvalho, Sara H.R.Lavorato, Victor N.Gomes, Luis Henrique L.S.Castro, Quênia J.T.Grabe-Guimarães, AndreaCarneiro, Cláudia M.Natali, Antônio J.Isoldi, Mauro C.2018-04-19T19:39:46Z2018-04-19T19:39:46Z2017-08-1100243205https://doi.org/10.1016/j.lfs.2017.08.014http://www.locus.ufv.br/handle/123456789/18910Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were submitted to a swimming protocol (1 h/day, 5 times/week, no additional load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical properties. Myocytes were stimulted at frequencies (F) of 1 and 3 Hz at 37 °C. Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR (mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46% to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to sedentary SHR. Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension in male SHR.engLife Sciencesv. 187, p. 42-49, October 2017Elsevier Inc.info:eu-repo/semantics/openAccessCardiac remodelingHypertensionSpontaneously hypertensive ratsSwim trainingCardiomyocytesSwim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertensioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdfTexto completoapplication/pdf949499https://locus.ufv.br//bitstream/123456789/18910/1/artigo.pdf24848e45686a064cf5a5459a2fcc95c9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/18910/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg6067https://locus.ufv.br//bitstream/123456789/18910/3/artigo.pdf.jpgc516da41d665550697427c1eeeac8553MD53123456789/189102018-04-19 23:00:53.135oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-04-20T02:00:53LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.pt-BR.fl_str_mv |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension |
title |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension |
spellingShingle |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension Locatelli, Jamille Cardiac remodeling Hypertension Spontaneously hypertensive rats Swim training Cardiomyocytes |
title_short |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension |
title_full |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension |
title_fullStr |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension |
title_full_unstemmed |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension |
title_sort |
Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension |
author |
Locatelli, Jamille |
author_facet |
Locatelli, Jamille Paiva, Nívia C.N. Carvalho, Sara H.R. Lavorato, Victor N. Gomes, Luis Henrique L.S. Castro, Quênia J.T. Grabe-Guimarães, Andrea Carneiro, Cláudia M. Natali, Antônio J. Isoldi, Mauro C. |
author_role |
author |
author2 |
Paiva, Nívia C.N. Carvalho, Sara H.R. Lavorato, Victor N. Gomes, Luis Henrique L.S. Castro, Quênia J.T. Grabe-Guimarães, Andrea Carneiro, Cláudia M. Natali, Antônio J. Isoldi, Mauro C. |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Locatelli, Jamille Paiva, Nívia C.N. Carvalho, Sara H.R. Lavorato, Victor N. Gomes, Luis Henrique L.S. Castro, Quênia J.T. Grabe-Guimarães, Andrea Carneiro, Cláudia M. Natali, Antônio J. Isoldi, Mauro C. |
dc.subject.pt-BR.fl_str_mv |
Cardiac remodeling Hypertension Spontaneously hypertensive rats Swim training Cardiomyocytes |
topic |
Cardiac remodeling Hypertension Spontaneously hypertensive rats Swim training Cardiomyocytes |
description |
Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were submitted to a swimming protocol (1 h/day, 5 times/week, no additional load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical properties. Myocytes were stimulted at frequencies (F) of 1 and 3 Hz at 37 °C. Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR (mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46% to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to sedentary SHR. Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension in male SHR. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-08-11 |
dc.date.accessioned.fl_str_mv |
2018-04-19T19:39:46Z |
dc.date.available.fl_str_mv |
2018-04-19T19:39:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1016/j.lfs.2017.08.014 http://www.locus.ufv.br/handle/123456789/18910 |
dc.identifier.issn.none.fl_str_mv |
00243205 |
identifier_str_mv |
00243205 |
url |
https://doi.org/10.1016/j.lfs.2017.08.014 http://www.locus.ufv.br/handle/123456789/18910 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.pt-BR.fl_str_mv |
v. 187, p. 42-49, October 2017 |
dc.rights.driver.fl_str_mv |
Elsevier Inc. info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Elsevier Inc. |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Life Sciences |
publisher.none.fl_str_mv |
Life Sciences |
dc.source.none.fl_str_mv |
reponame:LOCUS Repositório Institucional da UFV instname:Universidade Federal de Viçosa (UFV) instacron:UFV |
instname_str |
Universidade Federal de Viçosa (UFV) |
instacron_str |
UFV |
institution |
UFV |
reponame_str |
LOCUS Repositório Institucional da UFV |
collection |
LOCUS Repositório Institucional da UFV |
bitstream.url.fl_str_mv |
https://locus.ufv.br//bitstream/123456789/18910/1/artigo.pdf https://locus.ufv.br//bitstream/123456789/18910/2/license.txt https://locus.ufv.br//bitstream/123456789/18910/3/artigo.pdf.jpg |
bitstream.checksum.fl_str_mv |
24848e45686a064cf5a5459a2fcc95c9 8a4605be74aa9ea9d79846c1fba20a33 c516da41d665550697427c1eeeac8553 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV) |
repository.mail.fl_str_mv |
fabiojreis@ufv.br |
_version_ |
1801213063041384448 |