Efeito da exposição crônica ao níquel nos testículos de ratos Wister adultos

• Autor(a) principal: Oliveira, Mônica de Fátima
• Data de Publicação: 2010
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/2329
• topic: Níquel; Toxicologia; Testículo; Nickel; Toxicology; Testis; CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL

The toxicity of a metal depends on its inherent capacity to adversely affect any biologic activity. Among the environmental pollutants, nickel, a heavy metal, merits special highlights as a potential toxic element. The acute or chronic exposure to nickel, results in effects various on reproduction, being targeting, the testis, which is an organ highly susceptible to this noxious agent. In this study, was evaluated the chronic effect of nickel over corporal and testis biometry and tubular and intertubular compartments in Wistar rats on reproductive age. Were utilized 24 rats divided into three groups with eight animals. Group 1, control, received deionized water, treated groups received the nickel salt in the form of nickel chloride NiCl2 in the doses of 20mgNi/day (group 2) and 40mgNi/day (group 3) for 60 days. Chronic administration of nickel caused reduction in prostate weight and reduced food intake by the animals, independently concentration used. The animals that received the highest dose showed reduction in the corporal weight in the testicular components, epididym, seminiferous epithelial height, diameter seminiferous tubules and at the tubular volume. Regarding the intertubular compartment, nickel caused reduction in the total volume of Leydig cells, and consequently of the Leydigosomatic index. It was also observed in this group, reduction the volumetric proportion of macrophages and increase volumetric proportion in lymphatic space. In the histopathological evaluation of testicular parenchyma were observed punctual pathologies of the seminiferous epithelial related to vacuolation, cell detachment and depletion of germ cells in two animals all seminiferous tubules showed committed. Among the changes in these animals, the above data suggest that high doses of nickel may affect steroidogenesis and impair the spermatogenic process.