Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | LOCUS Repositório Institucional da UFV |
| Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001400172 https://locus.ufv.br//handle/123456789/29581 |
Resumo: | Link errado. Favor verificar. |
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Rodrigues, Joel AlvesPrímola-Gomes, Thales NicolauLeal, Tiago FerreiraPedrosa, Danillo LaviolaRezende, Leonardo Mateus TeixeiraNatali, Antonio JoseNóbrega, ClaraOliveira, Edilamar Menezes de2022-08-08T18:25:18Z2022-08-08T18:25:18Z2018-081678-4170http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001400172https://locus.ufv.br//handle/123456789/29581Link errado. Favor verificar.Regulation of intracellular calcium (Ca2+) in cardiomyocytes is altered by hypertension; and aerobic exercise brings benefits to hypertensive individuals. To verify the effects of aerobic exercise training on contractility and intracellular calcium (Ca2+) transients of cardiomyocytes and on the expression of microRNA 214 (miR-214) in the left ventricle of spontaneously hypertensive rats (SHR). SHR and normotensive Wistar rats of 16 weeks were divided into 4 groups -sedentary hypertensive (SH); trained hypertensive (TH); sedentary normotensive (SN); and trained normotensive (TN). Animals of the TH and TN groups were subjected to treadmill running program, 5 days/week, 1 hour/day at 60-70% of maximum running velocity for 8 weeks. We adopted a p ≤ 0.05 as significance level for all comparisons. Exercise training reduced systolic arterial pressure in hypertensive rats. In normotensive rats, exercise training reduced the time to 50% cell relaxation and the time to peak contraction and increased the time to 50% decay of the intracellular Ca2+ transients. In SHR, exercise increased the amplitude and reduced the time to 50% decay of Ca2+transients. Exercise training increased the expression of miR-214 in hypertensive rats only. The aerobic training applied in this study increased the availability of intracellular Ca2+ and accelerated the sequestration of these ions in left ventricular myocytes of hypertensive rats, despite increased expression of miR-214 and maintenance of cell contractility.engArquivos Brasileiros de Cardiologiav. 111, n. 02, p. 172-179, ago. 2018HypertensionExerciseRatsCalcium signalingIntracellular calciumSensing ProteinsPhysical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdfTexto completoapplication/pdf457546https://locus.ufv.br//bitstream/123456789/29581/1/artigo.pdf0f62ffd903d3fffcbf9cdf8bdb2d5a91MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/29581/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/295812022-08-08 15:25:18.765oai:locus.ufv.br:123456789/29581Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452022-08-08T18:25:18LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
| dc.title.pt-BR.fl_str_mv |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
| title |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
| spellingShingle |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats Rodrigues, Joel Alves Hypertension Exercise Rats Calcium signaling Intracellular calcium Sensing Proteins |
| title_short |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
| title_full |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
| title_fullStr |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
| title_full_unstemmed |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
| title_sort |
Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats |
| author |
Rodrigues, Joel Alves |
| author_facet |
Rodrigues, Joel Alves Prímola-Gomes, Thales Nicolau Leal, Tiago Ferreira Pedrosa, Danillo Laviola Rezende, Leonardo Mateus Teixeira Natali, Antonio Jose Nóbrega, Clara Oliveira, Edilamar Menezes de |
| author_role |
author |
| author2 |
Prímola-Gomes, Thales Nicolau Leal, Tiago Ferreira Pedrosa, Danillo Laviola Rezende, Leonardo Mateus Teixeira Natali, Antonio Jose Nóbrega, Clara Oliveira, Edilamar Menezes de |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rodrigues, Joel Alves Prímola-Gomes, Thales Nicolau Leal, Tiago Ferreira Pedrosa, Danillo Laviola Rezende, Leonardo Mateus Teixeira Natali, Antonio Jose Nóbrega, Clara Oliveira, Edilamar Menezes de |
| dc.subject.pt-BR.fl_str_mv |
Hypertension Exercise Rats Calcium signaling Intracellular calcium Sensing Proteins |
| topic |
Hypertension Exercise Rats Calcium signaling Intracellular calcium Sensing Proteins |
| description |
Link errado. Favor verificar. |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018-08 |
| dc.date.accessioned.fl_str_mv |
2022-08-08T18:25:18Z |
| dc.date.available.fl_str_mv |
2022-08-08T18:25:18Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001400172 https://locus.ufv.br//handle/123456789/29581 |
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1678-4170 |
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1678-4170 |
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2018001400172 https://locus.ufv.br//handle/123456789/29581 |
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eng |
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eng |
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v. 111, n. 02, p. 172-179, ago. 2018 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Arquivos Brasileiros de Cardiologia |
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Arquivos Brasileiros de Cardiologia |
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