Calcium and caffeine interaction in increased calcium balance in ovariectomized rats

Detalhes bibliográficos
Autor(a) principal: Silva, Sandra Tavares da
Data de Publicação: 2013
Outros Autores: Costa, Neuza Maria Brunoro, Franco, Frederico Souzalima Caldoncelli, Natali, Antônio José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.1590/S1415-52732013000300006
http://www.locus.ufv.br/handle/123456789/17640
Resumo: This study investigated the effects of caffeine intake associated with inadequate or adequate calcium intake in laparotomized or ovariectomized rats by means of the calcium balance. Forty adults Wistar rats were ovariectomized or laparotomized. The animals (n=40) were randomly placed in eight groups receiving the AIN-93 diet with 100% or 50% of the recommended calcium intake with or without added caffeine (6mg/kg/day). The animals were kept in individuals metabolic cages at a temperature of 24°±2oC, light/dark cycles of 12/12 hours, and deionized water available ad libitum. On the 8th week of the experiment, food consumption was measured and 24-hour urine and 4-day feces were collected to determine calcium balance [Balance=Ca intake-(Urinary Ca+Fecal Ca)]. Animals with adequate calcium intake presented higher balances and rates of calcium absorption and retention (p<0.05) than those with inadequate calcium intake, regardless of caffeine intake (p<0.05). Caffeine intake did not affect urinary calcium excretion but increased balance (p<0.05) in the groups with adequate calcium intake. Adequate calcium intake attenuated the negative effects of estrogen deficiency and improved calcium balance even in the presence of caffeine.
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spelling Calcium and caffeine interaction in increased calcium balance in ovariectomized ratsCaffeineCalcium bioavailabilityEstrogenThis study investigated the effects of caffeine intake associated with inadequate or adequate calcium intake in laparotomized or ovariectomized rats by means of the calcium balance. Forty adults Wistar rats were ovariectomized or laparotomized. The animals (n=40) were randomly placed in eight groups receiving the AIN-93 diet with 100% or 50% of the recommended calcium intake with or without added caffeine (6mg/kg/day). The animals were kept in individuals metabolic cages at a temperature of 24°±2oC, light/dark cycles of 12/12 hours, and deionized water available ad libitum. On the 8th week of the experiment, food consumption was measured and 24-hour urine and 4-day feces were collected to determine calcium balance [Balance=Ca intake-(Urinary Ca+Fecal Ca)]. Animals with adequate calcium intake presented higher balances and rates of calcium absorption and retention (p<0.05) than those with inadequate calcium intake, regardless of caffeine intake (p<0.05). Caffeine intake did not affect urinary calcium excretion but increased balance (p<0.05) in the groups with adequate calcium intake. Adequate calcium intake attenuated the negative effects of estrogen deficiency and improved calcium balance even in the presence of caffeine.Investigar a relação entre a ingestão de cafeína e a adequação de cálcio dietético em ratas ovariectomizadas ou inteiras, por meio do balanço de cálcio. Foram utilizadas 40 ratas Wistar adultas submetidas à cirurgia de ovariectomia ou laparotomia. Os animais foram alocados em grupos (n=5) e receberam dieta AIN-93M contendo 100 ou 50% da recomendação de cálcio com ou sem adição de cafeína (6mg/kg/dia). As fêmeas foram alojadas em gaiolas metabólicas individuais, à temperatura de 24±2oC e ciclo de 12 horas claro/escuro e receberam água deionizada ad libitum. Na oitava semana de experimento, quantificou-se a ingestão da dieta e coletaram-se fezes de 4 dias e urina dos animais por 24 horas para determinação do balanço [Balanço=Ca Ingerido - (Ca Fecal+Ca Urinário)]. Por meio de interação entre fatores, foi observado que o consumo de 100% de cálcio elevou o balanço e os teores de cálcio absorvido e retido (p<0,05) quando comparados aos grupos 50%. As ratas com adequação no consumo de cálcio aumentaram o balanço (p<0,05), independentemente da suplementação de cafeína. A ingestão de cafeína não afetou a excreção urinária de cálcio e elevou (p<0,05) o balanço nas ratas com 100% de cálcio, mas não nas com 50%. A adequação no consumo de cálcio atenuou os efeitos deletérios da redução estrogênica e proporcionou maior balanço de cálcio mesmo com ingestão de cafeína.Revista de Nutrição2018-02-16T09:20:33Z2018-02-16T09:20:33Z2013-02-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf1678-9865http://dx.doi.org/10.1590/S1415-52732013000300006http://www.locus.ufv.br/handle/123456789/17640engp. 26, n. 3, p. 313-322, May/June 2013Silva, Sandra Tavares daCosta, Neuza Maria BrunoroFranco, Frederico Souzalima CaldoncelliNatali, Antônio Joséinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFV2024-07-12T08:42:13Zoai:locus.ufv.br:123456789/17640Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452024-07-12T08:42:13LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.none.fl_str_mv Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
title Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
spellingShingle Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
Silva, Sandra Tavares da
Caffeine
Calcium bioavailability
Estrogen
title_short Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
title_full Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
title_fullStr Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
title_full_unstemmed Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
title_sort Calcium and caffeine interaction in increased calcium balance in ovariectomized rats
author Silva, Sandra Tavares da
author_facet Silva, Sandra Tavares da
Costa, Neuza Maria Brunoro
Franco, Frederico Souzalima Caldoncelli
Natali, Antônio José
author_role author
author2 Costa, Neuza Maria Brunoro
Franco, Frederico Souzalima Caldoncelli
Natali, Antônio José
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva, Sandra Tavares da
Costa, Neuza Maria Brunoro
Franco, Frederico Souzalima Caldoncelli
Natali, Antônio José
dc.subject.por.fl_str_mv Caffeine
Calcium bioavailability
Estrogen
topic Caffeine
Calcium bioavailability
Estrogen
description This study investigated the effects of caffeine intake associated with inadequate or adequate calcium intake in laparotomized or ovariectomized rats by means of the calcium balance. Forty adults Wistar rats were ovariectomized or laparotomized. The animals (n=40) were randomly placed in eight groups receiving the AIN-93 diet with 100% or 50% of the recommended calcium intake with or without added caffeine (6mg/kg/day). The animals were kept in individuals metabolic cages at a temperature of 24°±2oC, light/dark cycles of 12/12 hours, and deionized water available ad libitum. On the 8th week of the experiment, food consumption was measured and 24-hour urine and 4-day feces were collected to determine calcium balance [Balance=Ca intake-(Urinary Ca+Fecal Ca)]. Animals with adequate calcium intake presented higher balances and rates of calcium absorption and retention (p<0.05) than those with inadequate calcium intake, regardless of caffeine intake (p<0.05). Caffeine intake did not affect urinary calcium excretion but increased balance (p<0.05) in the groups with adequate calcium intake. Adequate calcium intake attenuated the negative effects of estrogen deficiency and improved calcium balance even in the presence of caffeine.
publishDate 2013
dc.date.none.fl_str_mv 2013-02-05
2018-02-16T09:20:33Z
2018-02-16T09:20:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv 1678-9865
http://dx.doi.org/10.1590/S1415-52732013000300006
http://www.locus.ufv.br/handle/123456789/17640
identifier_str_mv 1678-9865
url http://dx.doi.org/10.1590/S1415-52732013000300006
http://www.locus.ufv.br/handle/123456789/17640
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv p. 26, n. 3, p. 313-322, May/June 2013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Revista de Nutrição
publisher.none.fl_str_mv Revista de Nutrição
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
instacron_str UFV
institution UFV
reponame_str LOCUS Repositório Institucional da UFV
collection LOCUS Repositório Institucional da UFV
repository.name.fl_str_mv LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)
repository.mail.fl_str_mv fabiojreis@ufv.br
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