Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Tipo de documento: | Tese |
Idioma: | spa |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://locus.ufv.br//handle/123456789/30188 |
Resumo: | Introduction: Aging causes physiological, morphological, and functional changes in the body that result in the decreased physical capacity and losses in physiological functions. Strength training (ST), in turn, is a strategy widely used to try to curb the deleterious effects of aging, especially on morphology and functional capacity; however, the body of evidence does not make it clear whether a ST program is able to promote changes in the mitophagic capacity of elderly people, which became the main research question of this dissertation. Objective: To analyze the effects of an ST program on the different muscle strength manifestations, functional fitness indicators, body composition, and mitophagy signaling proteins in the elderly people. Methods: 48 volunteers aged between 70 and 77 years, were divided into two groups, control (CG: without ST) and strength (STG: with ST). They were evaluated by means of maximal strength tests (dynamic, isometric, and power), functional capacity body composition, and blood extraction for analysis of mitophagy proteins, before and after the completion of an ST program. The training was composed by 8 exercises, for the main muscle groups, performed with 3 sets of 8–12 repetitions, and intensity of 5–8 on the OMNI-RES scale. Intragroup comparison was done using the Wilcoxon test and intergroup comparison, using the Mann–Whitney test. Cohen’s D test was used to verify the effect size. Results: As main results revealed, the participants of the STG improved the upper and lower limbs strength, the lower limbs power and the functional capacity after the 8 weeks of training. In addition, significant improvements were observed in PGC-1α, BNIP3, and NIX proteins in the STG, in comparison with the CG. Conclusions: The ST program carried out by elderly people produced increases in the muscle strength, muscle power, and functional capacity in addition to producing positive changes in the macroautophagy, mitochondrial biogenesys and mitophagy proteins, especially in those related to NIX/Bnip3 mitophagy pathway. Key words: Aging, strength training, muscle strength, muscle power, functional capacity, body composition, autophagy mitophagy. |
id |
UFV_9494515da256d28b45a4ed3c95e26790 |
---|---|
oai_identifier_str |
oai:locus.ufv.br:123456789/30188 |
network_acronym_str |
UFV |
network_name_str |
LOCUS Repositório Institucional da UFV |
repository_id_str |
2145 |
spelling |
González, María José CuevasMoreira, Osvaldo Costahttp://lattes.cnpq.br/6694501097425776Fernández, José Antonio de Paz2022-11-03T18:58:25Z2022-11-03T18:58:25Z2018-05-25MOREIRA, Osvaldo Costa. Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores. 2018. 303 p. Tese (Doutorado em Ciencias de la Actividad Física y del Deporte) - Universidad de León, León. 2018.https://locus.ufv.br//handle/123456789/30188Introduction: Aging causes physiological, morphological, and functional changes in the body that result in the decreased physical capacity and losses in physiological functions. Strength training (ST), in turn, is a strategy widely used to try to curb the deleterious effects of aging, especially on morphology and functional capacity; however, the body of evidence does not make it clear whether a ST program is able to promote changes in the mitophagic capacity of elderly people, which became the main research question of this dissertation. Objective: To analyze the effects of an ST program on the different muscle strength manifestations, functional fitness indicators, body composition, and mitophagy signaling proteins in the elderly people. Methods: 48 volunteers aged between 70 and 77 years, were divided into two groups, control (CG: without ST) and strength (STG: with ST). They were evaluated by means of maximal strength tests (dynamic, isometric, and power), functional capacity body composition, and blood extraction for analysis of mitophagy proteins, before and after the completion of an ST program. The training was composed by 8 exercises, for the main muscle groups, performed with 3 sets of 8–12 repetitions, and intensity of 5–8 on the OMNI-RES scale. Intragroup comparison was done using the Wilcoxon test and intergroup comparison, using the Mann–Whitney test. Cohen’s D test was used to verify the effect size. Results: As main results revealed, the participants of the STG improved the upper and lower limbs strength, the lower limbs power and the functional capacity after the 8 weeks of training. In addition, significant improvements were observed in PGC-1α, BNIP3, and NIX proteins in the STG, in comparison with the CG. Conclusions: The ST program carried out by elderly people produced increases in the muscle strength, muscle power, and functional capacity in addition to producing positive changes in the macroautophagy, mitochondrial biogenesys and mitophagy proteins, especially in those related to NIX/Bnip3 mitophagy pathway. Key words: Aging, strength training, muscle strength, muscle power, functional capacity, body composition, autophagy mitophagy.Introducción: El envejecimiento provoca cambios fisiológicos, morfológicos y funcionales en el organismo que resulta en disminución de la capacidad física y pérdidas en las funciones fisiológicas. El entrenamiento de fuerza (EF), a su vez, es una estrategia ampliamente empleada para intentar frenar los efectos degenerativos del envejecimiento, especialmente, sobre la morfología y la capacidad funcional. Sin embargo, la literatura científica no deja claro si un programa de EF es capaz de promover cambios en la capacidad mitofágica de las personas mayores, lo que se convirtió en la principal pregunta de investigación del presente trabajo. Objetivo: Analizar los efectos de un programa de EF sobre las diferentes manifestaciones de la fuerza muscular, los indicadores de aptitud funcional, la composición corporal y las proteínas de señalización de la mitofagia en personas mayores. Metodología: 48voluntarios con edad entre 70 y 77 años fueron divididos en dos grupos, control (GC: sin EF) y fuerza (GF: con EF). Fueron evaluados por medio de pruebas de fuerza máxima (dinámica, isométrica y potencia), capacidad funcional, composición corporal y extracción de sangre para análisis de las proteínas de mitofagia, antes y después de la realización de un programa de EF. El entrenamiento fue compuesto por 8 ejercicios, para los principales grupos musculares, ejecutados con intensidad de 5-8 en la escala OMNI-RES, en 3 series de 8-12 repeticiones. Para la comparación intragrupo fue utilizada la prueba de Wilcoxon y para la comparación intergrupos fue utilizada la prueba de Mann-Whitney. La prueba D de Cohen fue utilizada para verificar el tamaño del efecto. Resultados: Los principales resultados encontrados fueron que los participantes del GF mejoraron la fuerza de los miembros superiores e inferiores, la potencia de los miembros inferiores y la capacidad funcional tras las 8 semanas de entrenamiento. Además, fueron observadas mejoras significativas en las proteínas PGC-1α, BNIP3 y NIX en el GF, en comparación con el GC. Conclusiones: El programa de EF realizado por las personas mayores de 70 años produjo incrementos de la fuerza/potencia muscular y de la capacidad funcional, además de producir cambios positivos en las proteínas de macroautofagia, biogénesis mitocondrial y mitofagia, especialmente, en aquellas relacionadas con la vía NIX/Bnip3 de la mitofagia.Palabras clave: Envejecimiento, entrenamiento de fuerza, fuerza muscular, potencia muscular, capacidad funcional, composición corporal, autofagia, mitofagia.spaUniversidad de LeónExternas/Outras InstituiçõesCiências da SaúdeEducação FísicaFisiologíaAntropología físicaFisiología del ejercicioFisiología del músculoMitofagíaEntrenamientoEstudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayoresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisUniversidad de LeónULe - Departamento de Ciencias BiomédicasDoutor em Ciencias de la Actividad Física y del DeporteLeón - Espanha2018-05-25Doutoradoinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/30188/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALtexto completo.pdftexto completo.pdftexto completoapplication/pdf4348900https://locus.ufv.br//bitstream/123456789/30188/1/texto%20completo.pdf8c776b367cb285324d10da553937339fMD51123456789/301882022-11-08 15:58:23.772oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452022-11-08T18:58:23LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.es.fl_str_mv |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores |
title |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores |
spellingShingle |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores Moreira, Osvaldo Costa Ciências da Saúde Educação Física Fisiología Antropología física Fisiología del ejercicio Fisiología del músculo Mitofagía Entrenamiento |
title_short |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores |
title_full |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores |
title_fullStr |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores |
title_full_unstemmed |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores |
title_sort |
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores |
author |
Moreira, Osvaldo Costa |
author_facet |
Moreira, Osvaldo Costa |
author_role |
author |
dc.contributor.authorLattes.pt-BR.fl_str_mv |
http://lattes.cnpq.br/6694501097425776 |
dc.contributor.none.fl_str_mv |
González, María José Cuevas |
dc.contributor.author.fl_str_mv |
Moreira, Osvaldo Costa |
dc.contributor.advisor1.fl_str_mv |
Fernández, José Antonio de Paz |
contributor_str_mv |
Fernández, José Antonio de Paz |
dc.subject.cnpq.fl_str_mv |
Ciências da Saúde Educação Física |
topic |
Ciências da Saúde Educação Física Fisiología Antropología física Fisiología del ejercicio Fisiología del músculo Mitofagía Entrenamiento |
dc.subject.spa.fl_str_mv |
Fisiología Antropología física Fisiología del ejercicio Fisiología del músculo Mitofagía Entrenamiento |
description |
Introduction: Aging causes physiological, morphological, and functional changes in the body that result in the decreased physical capacity and losses in physiological functions. Strength training (ST), in turn, is a strategy widely used to try to curb the deleterious effects of aging, especially on morphology and functional capacity; however, the body of evidence does not make it clear whether a ST program is able to promote changes in the mitophagic capacity of elderly people, which became the main research question of this dissertation. Objective: To analyze the effects of an ST program on the different muscle strength manifestations, functional fitness indicators, body composition, and mitophagy signaling proteins in the elderly people. Methods: 48 volunteers aged between 70 and 77 years, were divided into two groups, control (CG: without ST) and strength (STG: with ST). They were evaluated by means of maximal strength tests (dynamic, isometric, and power), functional capacity body composition, and blood extraction for analysis of mitophagy proteins, before and after the completion of an ST program. The training was composed by 8 exercises, for the main muscle groups, performed with 3 sets of 8–12 repetitions, and intensity of 5–8 on the OMNI-RES scale. Intragroup comparison was done using the Wilcoxon test and intergroup comparison, using the Mann–Whitney test. Cohen’s D test was used to verify the effect size. Results: As main results revealed, the participants of the STG improved the upper and lower limbs strength, the lower limbs power and the functional capacity after the 8 weeks of training. In addition, significant improvements were observed in PGC-1α, BNIP3, and NIX proteins in the STG, in comparison with the CG. Conclusions: The ST program carried out by elderly people produced increases in the muscle strength, muscle power, and functional capacity in addition to producing positive changes in the macroautophagy, mitochondrial biogenesys and mitophagy proteins, especially in those related to NIX/Bnip3 mitophagy pathway. Key words: Aging, strength training, muscle strength, muscle power, functional capacity, body composition, autophagy mitophagy. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-05-25 |
dc.date.accessioned.fl_str_mv |
2022-11-03T18:58:25Z |
dc.date.available.fl_str_mv |
2022-11-03T18:58:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MOREIRA, Osvaldo Costa. Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores. 2018. 303 p. Tese (Doutorado em Ciencias de la Actividad Física y del Deporte) - Universidad de León, León. 2018. |
dc.identifier.uri.fl_str_mv |
https://locus.ufv.br//handle/123456789/30188 |
identifier_str_mv |
MOREIRA, Osvaldo Costa. Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores. 2018. 303 p. Tese (Doutorado em Ciencias de la Actividad Física y del Deporte) - Universidad de León, León. 2018. |
url |
https://locus.ufv.br//handle/123456789/30188 |
dc.language.iso.fl_str_mv |
spa |
language |
spa |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidad de León |
dc.publisher.program.fl_str_mv |
Externas/Outras Instituições |
publisher.none.fl_str_mv |
Universidad de León |
dc.source.none.fl_str_mv |
reponame:LOCUS Repositório Institucional da UFV instname:Universidade Federal de Viçosa (UFV) instacron:UFV |
instname_str |
Universidade Federal de Viçosa (UFV) |
instacron_str |
UFV |
institution |
UFV |
reponame_str |
LOCUS Repositório Institucional da UFV |
collection |
LOCUS Repositório Institucional da UFV |
bitstream.url.fl_str_mv |
https://locus.ufv.br//bitstream/123456789/30188/2/license.txt https://locus.ufv.br//bitstream/123456789/30188/1/texto%20completo.pdf |
bitstream.checksum.fl_str_mv |
8a4605be74aa9ea9d79846c1fba20a33 8c776b367cb285324d10da553937339f |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV) |
repository.mail.fl_str_mv |
fabiojreis@ufv.br |
_version_ |
1801212970926080000 |