Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores

Detalhes bibliográficos
Autor(a) principal: Moreira, Osvaldo Costa
Data de Publicação: 2018
Tipo de documento: Tese
Idioma: spa
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: https://locus.ufv.br//handle/123456789/30188
Resumo: Introduction: Aging causes physiological, morphological, and functional changes in the body that result in the decreased physical capacity and losses in physiological functions. Strength training (ST), in turn, is a strategy widely used to try to curb the deleterious effects of aging, especially on morphology and functional capacity; however, the body of evidence does not make it clear whether a ST program is able to promote changes in the mitophagic capacity of elderly people, which became the main research question of this dissertation. Objective: To analyze the effects of an ST program on the different muscle strength manifestations, functional fitness indicators, body composition, and mitophagy signaling proteins in the elderly people. Methods: 48 volunteers aged between 70 and 77 years, were divided into two groups, control (CG: without ST) and strength (STG: with ST). They were evaluated by means of maximal strength tests (dynamic, isometric, and power), functional capacity body composition, and blood extraction for analysis of mitophagy proteins, before and after the completion of an ST program. The training was composed by 8 exercises, for the main muscle groups, performed with 3 sets of 8–12 repetitions, and intensity of 5–8 on the OMNI-RES scale. Intragroup comparison was done using the Wilcoxon test and intergroup comparison, using the Mann–Whitney test. Cohen’s D test was used to verify the effect size. Results: As main results revealed, the participants of the STG improved the upper and lower limbs strength, the lower limbs power and the functional capacity after the 8 weeks of training. In addition, significant improvements were observed in PGC-1α, BNIP3, and NIX proteins in the STG, in comparison with the CG. Conclusions: The ST program carried out by elderly people produced increases in the muscle strength, muscle power, and functional capacity in addition to producing positive changes in the macroautophagy, mitochondrial biogenesys and mitophagy proteins, especially in those related to NIX/Bnip3 mitophagy pathway. Key words: Aging, strength training, muscle strength, muscle power, functional capacity, body composition, autophagy mitophagy.
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spelling González, María José CuevasMoreira, Osvaldo Costahttp://lattes.cnpq.br/6694501097425776Fernández, José Antonio de Paz2022-11-03T18:58:25Z2022-11-03T18:58:25Z2018-05-25MOREIRA, Osvaldo Costa. Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores. 2018. 303 p. Tese (Doutorado em Ciencias de la Actividad Física y del Deporte) - Universidad de León, León. 2018.https://locus.ufv.br//handle/123456789/30188Introduction: Aging causes physiological, morphological, and functional changes in the body that result in the decreased physical capacity and losses in physiological functions. Strength training (ST), in turn, is a strategy widely used to try to curb the deleterious effects of aging, especially on morphology and functional capacity; however, the body of evidence does not make it clear whether a ST program is able to promote changes in the mitophagic capacity of elderly people, which became the main research question of this dissertation. Objective: To analyze the effects of an ST program on the different muscle strength manifestations, functional fitness indicators, body composition, and mitophagy signaling proteins in the elderly people. Methods: 48 volunteers aged between 70 and 77 years, were divided into two groups, control (CG: without ST) and strength (STG: with ST). They were evaluated by means of maximal strength tests (dynamic, isometric, and power), functional capacity body composition, and blood extraction for analysis of mitophagy proteins, before and after the completion of an ST program. The training was composed by 8 exercises, for the main muscle groups, performed with 3 sets of 8–12 repetitions, and intensity of 5–8 on the OMNI-RES scale. Intragroup comparison was done using the Wilcoxon test and intergroup comparison, using the Mann–Whitney test. Cohen’s D test was used to verify the effect size. Results: As main results revealed, the participants of the STG improved the upper and lower limbs strength, the lower limbs power and the functional capacity after the 8 weeks of training. In addition, significant improvements were observed in PGC-1α, BNIP3, and NIX proteins in the STG, in comparison with the CG. Conclusions: The ST program carried out by elderly people produced increases in the muscle strength, muscle power, and functional capacity in addition to producing positive changes in the macroautophagy, mitochondrial biogenesys and mitophagy proteins, especially in those related to NIX/Bnip3 mitophagy pathway. Key words: Aging, strength training, muscle strength, muscle power, functional capacity, body composition, autophagy mitophagy.Introducción: El envejecimiento provoca cambios fisiológicos, morfológicos y funcionales en el organismo que resulta en disminución de la capacidad física y pérdidas en las funciones fisiológicas. El entrenamiento de fuerza (EF), a su vez, es una estrategia ampliamente empleada para intentar frenar los efectos degenerativos del envejecimiento, especialmente, sobre la morfología y la capacidad funcional. Sin embargo, la literatura científica no deja claro si un programa de EF es capaz de promover cambios en la capacidad mitofágica de las personas mayores, lo que se convirtió en la principal pregunta de investigación del presente trabajo. Objetivo: Analizar los efectos de un programa de EF sobre las diferentes manifestaciones de la fuerza muscular, los indicadores de aptitud funcional, la composición corporal y las proteínas de señalización de la mitofagia en personas mayores. Metodología: 48voluntarios con edad entre 70 y 77 años fueron divididos en dos grupos, control (GC: sin EF) y fuerza (GF: con EF). Fueron evaluados por medio de pruebas de fuerza máxima (dinámica, isométrica y potencia), capacidad funcional, composición corporal y extracción de sangre para análisis de las proteínas de mitofagia, antes y después de la realización de un programa de EF. El entrenamiento fue compuesto por 8 ejercicios, para los principales grupos musculares, ejecutados con intensidad de 5-8 en la escala OMNI-RES, en 3 series de 8-12 repeticiones. Para la comparación intragrupo fue utilizada la prueba de Wilcoxon y para la comparación intergrupos fue utilizada la prueba de Mann-Whitney. La prueba D de Cohen fue utilizada para verificar el tamaño del efecto. Resultados: Los principales resultados encontrados fueron que los participantes del GF mejoraron la fuerza de los miembros superiores e inferiores, la potencia de los miembros inferiores y la capacidad funcional tras las 8 semanas de entrenamiento. Además, fueron observadas mejoras significativas en las proteínas PGC-1α, BNIP3 y NIX en el GF, en comparación con el GC. Conclusiones: El programa de EF realizado por las personas mayores de 70 años produjo incrementos de la fuerza/potencia muscular y de la capacidad funcional, además de producir cambios positivos en las proteínas de macroautofagia, biogénesis mitocondrial y mitofagia, especialmente, en aquellas relacionadas con la vía NIX/Bnip3 de la mitofagia.Palabras clave: Envejecimiento, entrenamiento de fuerza, fuerza muscular, potencia muscular, capacidad funcional, composición corporal, autofagia, mitofagia.spaUniversidad de LeónExternas/Outras InstituiçõesCiências da SaúdeEducação FísicaFisiologíaAntropología físicaFisiología del ejercicioFisiología del músculoMitofagíaEntrenamientoEstudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayoresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisUniversidad de LeónULe - Departamento de Ciencias BiomédicasDoutor em Ciencias de la Actividad Física y del DeporteLeón - Espanha2018-05-25Doutoradoinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/30188/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALtexto completo.pdftexto completo.pdftexto completoapplication/pdf4348900https://locus.ufv.br//bitstream/123456789/30188/1/texto%20completo.pdf8c776b367cb285324d10da553937339fMD51123456789/301882022-11-08 15:58:23.772oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452022-11-08T18:58:23LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.es.fl_str_mv Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
title Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
spellingShingle Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
Moreira, Osvaldo Costa
Ciências da Saúde
Educação Física
Fisiología
Antropología física
Fisiología del ejercicio
Fisiología del músculo
Mitofagía
Entrenamiento
title_short Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
title_full Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
title_fullStr Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
title_full_unstemmed Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
title_sort Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores
author Moreira, Osvaldo Costa
author_facet Moreira, Osvaldo Costa
author_role author
dc.contributor.authorLattes.pt-BR.fl_str_mv http://lattes.cnpq.br/6694501097425776
dc.contributor.none.fl_str_mv González, María José Cuevas
dc.contributor.author.fl_str_mv Moreira, Osvaldo Costa
dc.contributor.advisor1.fl_str_mv Fernández, José Antonio de Paz
contributor_str_mv Fernández, José Antonio de Paz
dc.subject.cnpq.fl_str_mv Ciências da Saúde
Educação Física
topic Ciências da Saúde
Educação Física
Fisiología
Antropología física
Fisiología del ejercicio
Fisiología del músculo
Mitofagía
Entrenamiento
dc.subject.spa.fl_str_mv Fisiología
Antropología física
Fisiología del ejercicio
Fisiología del músculo
Mitofagía
Entrenamiento
description Introduction: Aging causes physiological, morphological, and functional changes in the body that result in the decreased physical capacity and losses in physiological functions. Strength training (ST), in turn, is a strategy widely used to try to curb the deleterious effects of aging, especially on morphology and functional capacity; however, the body of evidence does not make it clear whether a ST program is able to promote changes in the mitophagic capacity of elderly people, which became the main research question of this dissertation. Objective: To analyze the effects of an ST program on the different muscle strength manifestations, functional fitness indicators, body composition, and mitophagy signaling proteins in the elderly people. Methods: 48 volunteers aged between 70 and 77 years, were divided into two groups, control (CG: without ST) and strength (STG: with ST). They were evaluated by means of maximal strength tests (dynamic, isometric, and power), functional capacity body composition, and blood extraction for analysis of mitophagy proteins, before and after the completion of an ST program. The training was composed by 8 exercises, for the main muscle groups, performed with 3 sets of 8–12 repetitions, and intensity of 5–8 on the OMNI-RES scale. Intragroup comparison was done using the Wilcoxon test and intergroup comparison, using the Mann–Whitney test. Cohen’s D test was used to verify the effect size. Results: As main results revealed, the participants of the STG improved the upper and lower limbs strength, the lower limbs power and the functional capacity after the 8 weeks of training. In addition, significant improvements were observed in PGC-1α, BNIP3, and NIX proteins in the STG, in comparison with the CG. Conclusions: The ST program carried out by elderly people produced increases in the muscle strength, muscle power, and functional capacity in addition to producing positive changes in the macroautophagy, mitochondrial biogenesys and mitophagy proteins, especially in those related to NIX/Bnip3 mitophagy pathway. Key words: Aging, strength training, muscle strength, muscle power, functional capacity, body composition, autophagy mitophagy.
publishDate 2018
dc.date.issued.fl_str_mv 2018-05-25
dc.date.accessioned.fl_str_mv 2022-11-03T18:58:25Z
dc.date.available.fl_str_mv 2022-11-03T18:58:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
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dc.identifier.citation.fl_str_mv MOREIRA, Osvaldo Costa. Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores. 2018. 303 p. Tese (Doutorado em Ciencias de la Actividad Física y del Deporte) - Universidad de León, León. 2018.
dc.identifier.uri.fl_str_mv https://locus.ufv.br//handle/123456789/30188
identifier_str_mv MOREIRA, Osvaldo Costa. Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores. 2018. 303 p. Tese (Doutorado em Ciencias de la Actividad Física y del Deporte) - Universidad de León, León. 2018.
url https://locus.ufv.br//handle/123456789/30188
dc.language.iso.fl_str_mv spa
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dc.publisher.none.fl_str_mv Universidad de León
dc.publisher.program.fl_str_mv Externas/Outras Instituições
publisher.none.fl_str_mv Universidad de León
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