A utilização do sistema imune artificial para investigação dos mecanismos imunológicos da sepse

• Autor(a) principal: Sousa, Flávio Oliveira de
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/2681
• topic: Sepse; Sistema imunológico; Simulação por computador; AutoSimmune; Sepsis; Immune system; Computer simulation; AutoSimmune; CNPQ::CIENCIAS EXATAS E DA TERRA::CIENCIA DA COMPUTACAO

Given the importance of human diseases, this paper presents a study for the investigation in silico of the sepsis. Through a collection of articles we present the initial concepts which conducted the research on both the aspect of immunology and disease and the aspects of computational tools that enable the development of alternative immunological research. The article "Artificial Immune System" presents a theoretical review of the intersection of immunology and strategies in silico. The articles "The artificial neutrophil and the proposal of an in silico research of the immune response in human bacterial diseases" and "Artificial Macrophage and computational modeling of the human immune system to investigate the pathophysiology of sepsis" present the requirements for the neutrophil and macrophage computer simulation. The article "Sepsis Immunology: research through Computational Simulation with Multi-Agent Systems" presents the Auto Simmune and argues strategies in developing the model in elucidating the mechanisms of sepsis and the article "Predicting the occurrence of sepsis by in silico simulation" shows the model implementation and results which involve an increase in phagocyte (especially neutrophil), temperature raise and the presence of bacteria in the circulation, all compatible with the literature, thus pointing to the possibility of using the model in improving knowledge about the disease.