Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos

Detalhes bibliográficos
Autor(a) principal: Rosa, Damiana Diniz
Data de Publicação: 2010
Tipo de documento: Dissertação
Idioma: por
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://locus.ufv.br/handle/123456789/2730
Resumo: The action of oils and fats in human nutrition has been amply studied and discussed in recent decades. Attention has been given to the nutritional quality of these oils, where quantity and composition of fatty acids is important. Essential fatty acids are important due to the their pharmacological roles and as mediators of inflammatory reactions, directly related to immunological resistance, thromboticprocesses and neoplastic diseases. Experimental studies support the hypothesis that &#969;6 fatty acids contribute to progressive development of neoplastic wounds while &#969;3 fatty acids possess a protective action. The objective of the present study was to evaluate the effects of adding different oils to the diet (soy, olive, fish, flaxseed) for prevention of preneoplastic wounds on the colon of Wistar rats. Also evaluated was its effect on the lipid profile, inflammatory markers, migration of inflammatory cells and histological analysis of intestinal mucus of the animals. Two experiments were performed. In the first, and exploratory study was performed on adult Wistar rats fed with normolipid diets AIN-93M (4g/100g diet). The animals were divided in four groups and received diets based on soy (control), olive, fish and flaxseed oil ad libitum, for a period of 9 weeks. Biochemical parameters (total cholesterol, HDL-cholesterol and triglycerides), number of lymphocytes in the intestinal mucus and morphometry of the villi were evaluated. The group fed with fish oil presented the lowest values of total cholesterol, HDL-cholesterol and triglycerides (p<0.05). The grouptreated with fish and olive oil presented the best preservation of the intestinal villi. A smaller deposition of lymphocytes in the ileal mucus was verified in the flaxseed group (p<0.001). From these results a second experiment was developed with the intention of confirming the hypothesis of the chemopreventive effect of the oils (olive, fish and flaxseed) present in the normolipid diets and now administered to the animals induced to pre-neoplastic wounds. In this experiment, adult Wistar rats were treated with 1,2-dimethylhydrazine, at the dose of 40 mg/kg body weight, maintained in the same experimental conditions as before. The fatty acid profiles of the serum, xvii hepatic tissue, intra-abdominal fat and in the feces were evaluated; investigating the presence of bioactive amines in the hepatic tissue, inflammatory mediators (IL-8, MCP-1 and TGF-&#946;) in the colonial mucus, and counting the lymphocytes in the intestinal mucus and mophometry of the villi. It was verified that the group fed with fish oil presented greater levels of EPA (p=0.004) and DHA (p<0.001) in the liver and greater levels of linolenic acid (p=0.003) and EPA (p=0.011) in the intra-abdominal adipose tissue in relation to the other treatments. In these tissues, a lower &#969;6/&#969;3 ratio was verified in the groups fed with polyunsaturated oils (fish and flaxseed). Greater levels of &#945;-linolenic acid were excreted by the flaxseed group (p=0.014). No difference was encountered in the number of FCA between the groups fed with the different lipid sources (p>0.05). There was no difference in the expression of IL-8, TGF-&#946;, and MCP-1 in relation to the control (p>0.05). When comparatively evaluating expression of the cytokines, it was verified that the fish oil group expressed two times more TGF-&#946; and eight times less IL-8 in relation to the other treatments. The olive oil group presented lower levels of spermidine (p=0.008) in relation to the other treatments. The group fed with fish oil presented few deposits of lymphocytes in the ileal mucus (p<0.001). A morphmetric analysis showed that the treatments presented height of the villus, depth of the crypt and width of the villi less than that of the control (p<0.001). This study demonstrated that flaxseed, olive and fish oil presented different responses in relation to soy oil on the preservation of intestinal mucus and proliferation of lymphocytes in healthy Wistar rats. In animals treated with carcinogens, the fish oil presented an important protective effect on the colonial mucus. The &#945;-linolenic fatty acids, EPA and DHA present a differential metabolism in relation to incorporation in the hepatic and intra-abdominal tissues, formation of pre-neoplastic wounds and expression of inflammatory cytokines in the colon. Greater incorporation of PUFA from the &#969;3 series in the fish oil group suggests a modular effect on the inflammatory response, in function of the lower migration of lymphocytes in the intestinal mucus of this group.
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spelling Rosa, Damiana Dinizhttp://lattes.cnpq.br/1145163296557852Ribeiro, Sônia Machado Rochahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701461E0Neves, Clóvis Andradehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785611E1Peluzio, Maria do Carmo Gouveiahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723914H4Bressan, Josefinahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781728Y2Sabarense, Céphora Mariahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4784824P6Dias, Cristina Maria Ganns Chaveshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786741P62015-03-26T13:11:48Z2015-02-242015-03-26T13:11:48Z2010-02-18http://locus.ufv.br/handle/123456789/2730The action of oils and fats in human nutrition has been amply studied and discussed in recent decades. Attention has been given to the nutritional quality of these oils, where quantity and composition of fatty acids is important. Essential fatty acids are important due to the their pharmacological roles and as mediators of inflammatory reactions, directly related to immunological resistance, thromboticprocesses and neoplastic diseases. Experimental studies support the hypothesis that &#969;6 fatty acids contribute to progressive development of neoplastic wounds while &#969;3 fatty acids possess a protective action. The objective of the present study was to evaluate the effects of adding different oils to the diet (soy, olive, fish, flaxseed) for prevention of preneoplastic wounds on the colon of Wistar rats. Also evaluated was its effect on the lipid profile, inflammatory markers, migration of inflammatory cells and histological analysis of intestinal mucus of the animals. Two experiments were performed. In the first, and exploratory study was performed on adult Wistar rats fed with normolipid diets AIN-93M (4g/100g diet). The animals were divided in four groups and received diets based on soy (control), olive, fish and flaxseed oil ad libitum, for a period of 9 weeks. Biochemical parameters (total cholesterol, HDL-cholesterol and triglycerides), number of lymphocytes in the intestinal mucus and morphometry of the villi were evaluated. The group fed with fish oil presented the lowest values of total cholesterol, HDL-cholesterol and triglycerides (p<0.05). The grouptreated with fish and olive oil presented the best preservation of the intestinal villi. A smaller deposition of lymphocytes in the ileal mucus was verified in the flaxseed group (p<0.001). From these results a second experiment was developed with the intention of confirming the hypothesis of the chemopreventive effect of the oils (olive, fish and flaxseed) present in the normolipid diets and now administered to the animals induced to pre-neoplastic wounds. In this experiment, adult Wistar rats were treated with 1,2-dimethylhydrazine, at the dose of 40 mg/kg body weight, maintained in the same experimental conditions as before. The fatty acid profiles of the serum, xvii hepatic tissue, intra-abdominal fat and in the feces were evaluated; investigating the presence of bioactive amines in the hepatic tissue, inflammatory mediators (IL-8, MCP-1 and TGF-&#946;) in the colonial mucus, and counting the lymphocytes in the intestinal mucus and mophometry of the villi. It was verified that the group fed with fish oil presented greater levels of EPA (p=0.004) and DHA (p<0.001) in the liver and greater levels of linolenic acid (p=0.003) and EPA (p=0.011) in the intra-abdominal adipose tissue in relation to the other treatments. In these tissues, a lower &#969;6/&#969;3 ratio was verified in the groups fed with polyunsaturated oils (fish and flaxseed). Greater levels of &#945;-linolenic acid were excreted by the flaxseed group (p=0.014). No difference was encountered in the number of FCA between the groups fed with the different lipid sources (p>0.05). There was no difference in the expression of IL-8, TGF-&#946;, and MCP-1 in relation to the control (p>0.05). When comparatively evaluating expression of the cytokines, it was verified that the fish oil group expressed two times more TGF-&#946; and eight times less IL-8 in relation to the other treatments. The olive oil group presented lower levels of spermidine (p=0.008) in relation to the other treatments. The group fed with fish oil presented few deposits of lymphocytes in the ileal mucus (p<0.001). A morphmetric analysis showed that the treatments presented height of the villus, depth of the crypt and width of the villi less than that of the control (p<0.001). This study demonstrated that flaxseed, olive and fish oil presented different responses in relation to soy oil on the preservation of intestinal mucus and proliferation of lymphocytes in healthy Wistar rats. In animals treated with carcinogens, the fish oil presented an important protective effect on the colonial mucus. The &#945;-linolenic fatty acids, EPA and DHA present a differential metabolism in relation to incorporation in the hepatic and intra-abdominal tissues, formation of pre-neoplastic wounds and expression of inflammatory cytokines in the colon. Greater incorporation of PUFA from the &#969;3 series in the fish oil group suggests a modular effect on the inflammatory response, in function of the lower migration of lymphocytes in the intestinal mucus of this group.A ação de óleos e gorduras na nutrição humana tem sido amplamente pesquisada e discutida nas últimas décadas. Atenção tem sido dada à qualidade nutricional destes óleos, sendo importante a quantidade e composição dos ácidos graxos. Os ácidos graxos essenciais têm grande importância por seus papéis farmacológicos e como mediadores de reações inflamatórias, diretamente relacionadas à resistência imunológica, distúrbios metabólicos, processos trombóticos e doenças neoplásicas. Estudos experimentais sustentam a hipótese que os ácidos graxos da série &#969;6 contribuem para o desenvolvimento a progressão de lesões neoplásicas enquanto que os ácidos graxos da série &#969;3 possuem uma ação protetora. O presente estudo teve como objetivo avaliar os efeitos da adição à dieta de diferentes óleos (soja, oliva, peixe, linhaça) na prevenção de lesões préneoplásicas no cólon de ratos Wistar. Avaliou-se ainda, o seu efeito no perfil lipídico, marcadores inflamatórios, migração de células inflamatórias e análise histológica da mucosa intestinal dos animais. Foram realizados dois experimentos. No primeiro, um estudo exploratório foi realizado com ratos Wistar adultos alimentados com dietas normolipídicas AIN-93M (4g/100g dieta). Os animais foram divididos em quatro grupos e receberam dietas à base de óleo de soja (controle), oliva, peixe e linhaça ad libitum, por um período de 9 semanas. Foram avaliados os parâmetros bioquímicos (colesterol total, HDLcolesterol e triglicerídeos), contagem de linfócitos na mucosa intestinal e morfometria das vilosidades. O grupo alimentado com óleo de peixe apresentou menores valores de colesterol total, HDL-colesterol e triglicerídeos (p<0,05). Os grupos tratados com óleo de peixe e oliva apresentaram melhor preservação das vilosidades intestinais. Menor deposição de linfócitos na mucosa ileal foi verificada no grupo linhaça (p<0.001). A partir destes resultados foi desenvolvido um segundo experimento com o intuito de responder a hipótese do efeito quimiopreventivo dos óleos (oliva, peixe e linhaça) presentes nas dietas normolipídicas e administradas agora à animais induzidos a lesões pré-neoplásicas. Neste experimento, ratos Wistar adultos foram tratados com 1,2-dimetilhidrazina, na dose de 40mg/kg peso corporal, mantidos nas mesmas condições experimentais anteriores. Foi avaliado o perfil de ácidos graxos do soro, tecido hepático, gordura intra-abdominal e nas fezes; investigada a presença de aminas bioativas no tecido hepático, mediadores inflamatórios (IL-8, MCP-1 e TGF-&#946;) na mucosa colônica, realizada a contagem de linfócitos na mucosa intestinal e morfometria das vilosidades. Verificou-se que o grupo alimentado com óleo de peixe apresentou maiores níveis de EPA (p=0,004) e DHA (p<0,001) no fígado e maiores níveis do ácido linolênico (p=0,003) e EPA (p=0,011) no tecido adiposo intra-abdominal em relação aos demais tratamentos. Nestes tecidos, menor relação &#969;6/&#969;3 foi verificada nos grupos alimentados com óleos poliinsaturados (peixe e linhaça). Maiores níveis de ácido &#945;-linolênico foi excretado pelo grupo linhaça (p=0,014). Não foi encontrada diferença no número de FCA entre os grupos alimentados com as diferentes fontes lipídicas (p>0,05). Não houve diferença na expressão de IL-8, TGF-&#946;, e MCP-1 em relação ao controle (p>0,05). Ao avaliar comparativamente a expressão das citocinas, verificamos que o grupo peixe expressou duas vezes mais TGF-&#946; e oito vezes menos IL-8 em relação aos demais tratamentos).O grupo oliva apresentou menores níveis de espermidina (p=0,008) em relação aos demais tratamentos. O grupo alimentado com óleo de peixe apresentou menor deposição de linfócitos na mucosa ileal (p<0,001). A análise morfométrica mostrou que os tratamentos apresentaram altura de vilosidade, profundidade de cripta e largura de vilosidade menores que o controle (p<0,001). Este estudo demonstrou que os óleos de linhaça, oliva e peixe apresentam diferentes respostas em relação ao óleo de soja na preservação da mucosa intestinal e proliferação de linfócitos em ratos Wistar saudáveis. Em animais tratados com carcinógeno, o óleo de peixe apresentou um importante efeito protetor a mucosa colônica. Os ácidos graxos &#945;-linolênico, EPA e DHA apresentaram um metabolismo diferenciado em relação à incorporação nos tecidos hepático e intra-abdominal, à formação de pré-lesões neoplásicas e à expressão de citocinas inflamatórias no cólon. A maior incorporação de PUFA da série &#969;3 no grupo peixe sugere um efeito modulador da resposta inflamatória, em função da menor migração de linfócitos na mucosa intestinal deste grupo.Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorporUniversidade Federal de ViçosaMestrado em Ciência da NutriçãoUFVBRValor nutricional de alimentos e de dietas; Nutrição nas enfermidades agudas e crônicas não transmisÓleo de peixeÓleo de linhaçaFish oilFlaxseed oilCNPQ::CIENCIAS DA SAUDE::NUTRICAOLesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleosLesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleosPre-neoplastic lesion, lipid profile, inflammatory makers and intestinal histological aspects of Wistar rats fed with diets based on different oilsPre-neoplastic lesion, lipid profile, inflammatory makers and intestinal histological aspects of Wistar rats fed with diets based on different oilsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALtexto completo.pdftexto completo.pdfapplication/pdf4898839https://locus.ufv.br//bitstream/123456789/2730/1/texto%20completo.pdfb2343b887d60144e21f85c83fb914c9eMD51TEXTtexto completo.pdf.txttexto completo.pdf.txtExtracted texttext/plain286977https://locus.ufv.br//bitstream/123456789/2730/2/texto%20completo.pdf.txt7c183addd65255ebf6ca5f19971100cdMD52THUMBNAILtexto completo.pdf.jpgtexto completo.pdf.jpgIM Thumbnailimage/jpeg1023https://locus.ufv.br//bitstream/123456789/2730/3/texto%20completo.pdf.jpgc98cc0c45e2761a7cfa8c7bef111e356MD53123456789/27302016-04-08 23:07:20.703oai:locus.ufv.br:123456789/2730Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452016-04-09T02:07:20LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.por.fl_str_mv Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
dc.title.alternative.eng.fl_str_mv Pre-neoplastic lesion, lipid profile, inflammatory makers and intestinal histological aspects of Wistar rats fed with diets based on different oils
Pre-neoplastic lesion, lipid profile, inflammatory makers and intestinal histological aspects of Wistar rats fed with diets based on different oils
title Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
spellingShingle Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
Rosa, Damiana Diniz
Óleo de peixe
Óleo de linhaça
Fish oil
Flaxseed oil
CNPQ::CIENCIAS DA SAUDE::NUTRICAO
title_short Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
title_full Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
title_fullStr Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
title_full_unstemmed Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
title_sort Lesões pré-neoplásicas, perfil lipídico, marcadores inflamatórios e aspecto histológico intestinal de ratos Wistar alimentados com dietas à base de diferentes óleos
author Rosa, Damiana Diniz
author_facet Rosa, Damiana Diniz
author_role author
dc.contributor.authorLattes.por.fl_str_mv http://lattes.cnpq.br/1145163296557852
dc.contributor.author.fl_str_mv Rosa, Damiana Diniz
dc.contributor.advisor-co1.fl_str_mv Ribeiro, Sônia Machado Rocha
dc.contributor.advisor-co1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701461E0
dc.contributor.advisor-co2.fl_str_mv Neves, Clóvis Andrade
dc.contributor.advisor-co2Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4785611E1
dc.contributor.advisor1.fl_str_mv Peluzio, Maria do Carmo Gouveia
dc.contributor.advisor1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723914H4
dc.contributor.referee1.fl_str_mv Bressan, Josefina
dc.contributor.referee1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4781728Y2
dc.contributor.referee2.fl_str_mv Sabarense, Céphora Maria
dc.contributor.referee2Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4784824P6
dc.contributor.referee3.fl_str_mv Dias, Cristina Maria Ganns Chaves
dc.contributor.referee3Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4786741P6
contributor_str_mv Ribeiro, Sônia Machado Rocha
Neves, Clóvis Andrade
Peluzio, Maria do Carmo Gouveia
Bressan, Josefina
Sabarense, Céphora Maria
Dias, Cristina Maria Ganns Chaves
dc.subject.por.fl_str_mv Óleo de peixe
Óleo de linhaça
topic Óleo de peixe
Óleo de linhaça
Fish oil
Flaxseed oil
CNPQ::CIENCIAS DA SAUDE::NUTRICAO
dc.subject.eng.fl_str_mv Fish oil
Flaxseed oil
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::NUTRICAO
description The action of oils and fats in human nutrition has been amply studied and discussed in recent decades. Attention has been given to the nutritional quality of these oils, where quantity and composition of fatty acids is important. Essential fatty acids are important due to the their pharmacological roles and as mediators of inflammatory reactions, directly related to immunological resistance, thromboticprocesses and neoplastic diseases. Experimental studies support the hypothesis that &#969;6 fatty acids contribute to progressive development of neoplastic wounds while &#969;3 fatty acids possess a protective action. The objective of the present study was to evaluate the effects of adding different oils to the diet (soy, olive, fish, flaxseed) for prevention of preneoplastic wounds on the colon of Wistar rats. Also evaluated was its effect on the lipid profile, inflammatory markers, migration of inflammatory cells and histological analysis of intestinal mucus of the animals. Two experiments were performed. In the first, and exploratory study was performed on adult Wistar rats fed with normolipid diets AIN-93M (4g/100g diet). The animals were divided in four groups and received diets based on soy (control), olive, fish and flaxseed oil ad libitum, for a period of 9 weeks. Biochemical parameters (total cholesterol, HDL-cholesterol and triglycerides), number of lymphocytes in the intestinal mucus and morphometry of the villi were evaluated. The group fed with fish oil presented the lowest values of total cholesterol, HDL-cholesterol and triglycerides (p<0.05). The grouptreated with fish and olive oil presented the best preservation of the intestinal villi. A smaller deposition of lymphocytes in the ileal mucus was verified in the flaxseed group (p<0.001). From these results a second experiment was developed with the intention of confirming the hypothesis of the chemopreventive effect of the oils (olive, fish and flaxseed) present in the normolipid diets and now administered to the animals induced to pre-neoplastic wounds. In this experiment, adult Wistar rats were treated with 1,2-dimethylhydrazine, at the dose of 40 mg/kg body weight, maintained in the same experimental conditions as before. The fatty acid profiles of the serum, xvii hepatic tissue, intra-abdominal fat and in the feces were evaluated; investigating the presence of bioactive amines in the hepatic tissue, inflammatory mediators (IL-8, MCP-1 and TGF-&#946;) in the colonial mucus, and counting the lymphocytes in the intestinal mucus and mophometry of the villi. It was verified that the group fed with fish oil presented greater levels of EPA (p=0.004) and DHA (p<0.001) in the liver and greater levels of linolenic acid (p=0.003) and EPA (p=0.011) in the intra-abdominal adipose tissue in relation to the other treatments. In these tissues, a lower &#969;6/&#969;3 ratio was verified in the groups fed with polyunsaturated oils (fish and flaxseed). Greater levels of &#945;-linolenic acid were excreted by the flaxseed group (p=0.014). No difference was encountered in the number of FCA between the groups fed with the different lipid sources (p>0.05). There was no difference in the expression of IL-8, TGF-&#946;, and MCP-1 in relation to the control (p>0.05). When comparatively evaluating expression of the cytokines, it was verified that the fish oil group expressed two times more TGF-&#946; and eight times less IL-8 in relation to the other treatments. The olive oil group presented lower levels of spermidine (p=0.008) in relation to the other treatments. The group fed with fish oil presented few deposits of lymphocytes in the ileal mucus (p<0.001). A morphmetric analysis showed that the treatments presented height of the villus, depth of the crypt and width of the villi less than that of the control (p<0.001). This study demonstrated that flaxseed, olive and fish oil presented different responses in relation to soy oil on the preservation of intestinal mucus and proliferation of lymphocytes in healthy Wistar rats. In animals treated with carcinogens, the fish oil presented an important protective effect on the colonial mucus. The &#945;-linolenic fatty acids, EPA and DHA present a differential metabolism in relation to incorporation in the hepatic and intra-abdominal tissues, formation of pre-neoplastic wounds and expression of inflammatory cytokines in the colon. Greater incorporation of PUFA from the &#969;3 series in the fish oil group suggests a modular effect on the inflammatory response, in function of the lower migration of lymphocytes in the intestinal mucus of this group.
publishDate 2010
dc.date.issued.fl_str_mv 2010-02-18
dc.date.accessioned.fl_str_mv 2015-03-26T13:11:48Z
dc.date.available.fl_str_mv 2015-02-24
2015-03-26T13:11:48Z
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Universidade Federal de Viçosa
dc.publisher.program.fl_str_mv Mestrado em Ciência da Nutrição
dc.publisher.initials.fl_str_mv UFV
dc.publisher.country.fl_str_mv BR
dc.publisher.department.fl_str_mv Valor nutricional de alimentos e de dietas; Nutrição nas enfermidades agudas e crônicas não transmis
publisher.none.fl_str_mv Universidade Federal de Viçosa
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
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