Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | http://dx.doi.org/10.1111/jbg.12299 http://www.locus.ufv.br/handle/123456789/16476 |
Resumo: | We performed a genome-wide mapping for the age at first calving (AFC) with the goal of annotating candidate genes that regulate fertility in Nellore cattle. Phenotypic data from 762 cows and 777k SNP genotypes from 2,992 bulls and cows were used. Single nucleotide polymorphism (SNP) effects based on the single-step GBLUP methodology were blocked into adjacent windows of 1 Megabase (Mb) to explain the genetic variance. SNP windows explaining more than 0.40% of the AFC genetic variance were identified on chromosomes 2, 8, 9, 14, 16 and 17. From these windows, we identified 123 coding protein genes that were used to build gene networks. From the association study and derived gene networks, putative candidate genes (e.g., PAPPA, PREP, FER1L6, TPR, NMNAT1, ACAD10, PCMTD1, CRH, OPKR1, NPBWR1 and NCOA2) and transcription factors (TF) (STAT1, STAT3, RELA, E2F1 and EGR1) were strongly associated with female fertility (e.g., negative regulation of luteinizing hormone secretion, folliculogenesis and establishment of uterine receptivity). Evidence suggests that AFC inheritance is complex and controlled by multiple loci across the genome. As several windows explaining higher proportion of the genetic variance were identified on chromosome 14, further studies investigating the interaction across haplotypes to better understand the molecular architecture behind AFC in Nellore cattle should be undertaken. |
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Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattleBeef cattleGene functionSingle-stepWe performed a genome-wide mapping for the age at first calving (AFC) with the goal of annotating candidate genes that regulate fertility in Nellore cattle. Phenotypic data from 762 cows and 777k SNP genotypes from 2,992 bulls and cows were used. Single nucleotide polymorphism (SNP) effects based on the single-step GBLUP methodology were blocked into adjacent windows of 1 Megabase (Mb) to explain the genetic variance. SNP windows explaining more than 0.40% of the AFC genetic variance were identified on chromosomes 2, 8, 9, 14, 16 and 17. From these windows, we identified 123 coding protein genes that were used to build gene networks. From the association study and derived gene networks, putative candidate genes (e.g., PAPPA, PREP, FER1L6, TPR, NMNAT1, ACAD10, PCMTD1, CRH, OPKR1, NPBWR1 and NCOA2) and transcription factors (TF) (STAT1, STAT3, RELA, E2F1 and EGR1) were strongly associated with female fertility (e.g., negative regulation of luteinizing hormone secretion, folliculogenesis and establishment of uterine receptivity). Evidence suggests that AFC inheritance is complex and controlled by multiple loci across the genome. As several windows explaining higher proportion of the genetic variance were identified on chromosome 14, further studies investigating the interaction across haplotypes to better understand the molecular architecture behind AFC in Nellore cattle should be undertaken.Journal of Animal Breeding and Genetics2018-01-18T13:24:17Z2018-01-18T13:24:17Z2017-10-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdf1439-0388http://dx.doi.org/10.1111/jbg.12299http://www.locus.ufv.br/handle/123456789/16476eng134(6), p. 484-492, Oct. 2017Mota, R.R.Guimarães, S.E.F.Fortes, M.R.S.Hayes, B.Silva, F.F.Verardo, L.L.Kelly, M.J.Campos, C.F. deGuimarães, J.D.Wenceslau, R.R.Penitente-Filho, J.M.Garcia, J.F.Moore, S.info:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFV2024-07-12T07:00:20Zoai:locus.ufv.br:123456789/16476Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452024-07-12T07:00:20LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.none.fl_str_mv |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle |
title |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle |
spellingShingle |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle Mota, R.R. Beef cattle Gene function Single-step |
title_short |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle |
title_full |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle |
title_fullStr |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle |
title_full_unstemmed |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle |
title_sort |
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle |
author |
Mota, R.R. |
author_facet |
Mota, R.R. Guimarães, S.E.F. Fortes, M.R.S. Hayes, B. Silva, F.F. Verardo, L.L. Kelly, M.J. Campos, C.F. de Guimarães, J.D. Wenceslau, R.R. Penitente-Filho, J.M. Garcia, J.F. Moore, S. |
author_role |
author |
author2 |
Guimarães, S.E.F. Fortes, M.R.S. Hayes, B. Silva, F.F. Verardo, L.L. Kelly, M.J. Campos, C.F. de Guimarães, J.D. Wenceslau, R.R. Penitente-Filho, J.M. Garcia, J.F. Moore, S. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mota, R.R. Guimarães, S.E.F. Fortes, M.R.S. Hayes, B. Silva, F.F. Verardo, L.L. Kelly, M.J. Campos, C.F. de Guimarães, J.D. Wenceslau, R.R. Penitente-Filho, J.M. Garcia, J.F. Moore, S. |
dc.subject.por.fl_str_mv |
Beef cattle Gene function Single-step |
topic |
Beef cattle Gene function Single-step |
description |
We performed a genome-wide mapping for the age at first calving (AFC) with the goal of annotating candidate genes that regulate fertility in Nellore cattle. Phenotypic data from 762 cows and 777k SNP genotypes from 2,992 bulls and cows were used. Single nucleotide polymorphism (SNP) effects based on the single-step GBLUP methodology were blocked into adjacent windows of 1 Megabase (Mb) to explain the genetic variance. SNP windows explaining more than 0.40% of the AFC genetic variance were identified on chromosomes 2, 8, 9, 14, 16 and 17. From these windows, we identified 123 coding protein genes that were used to build gene networks. From the association study and derived gene networks, putative candidate genes (e.g., PAPPA, PREP, FER1L6, TPR, NMNAT1, ACAD10, PCMTD1, CRH, OPKR1, NPBWR1 and NCOA2) and transcription factors (TF) (STAT1, STAT3, RELA, E2F1 and EGR1) were strongly associated with female fertility (e.g., negative regulation of luteinizing hormone secretion, folliculogenesis and establishment of uterine receptivity). Evidence suggests that AFC inheritance is complex and controlled by multiple loci across the genome. As several windows explaining higher proportion of the genetic variance were identified on chromosome 14, further studies investigating the interaction across haplotypes to better understand the molecular architecture behind AFC in Nellore cattle should be undertaken. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-09 2018-01-18T13:24:17Z 2018-01-18T13:24:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
1439-0388 http://dx.doi.org/10.1111/jbg.12299 http://www.locus.ufv.br/handle/123456789/16476 |
identifier_str_mv |
1439-0388 |
url |
http://dx.doi.org/10.1111/jbg.12299 http://www.locus.ufv.br/handle/123456789/16476 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
134(6), p. 484-492, Oct. 2017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
pdf application/pdf |
dc.publisher.none.fl_str_mv |
Journal of Animal Breeding and Genetics |
publisher.none.fl_str_mv |
Journal of Animal Breeding and Genetics |
dc.source.none.fl_str_mv |
reponame:LOCUS Repositório Institucional da UFV instname:Universidade Federal de Viçosa (UFV) instacron:UFV |
instname_str |
Universidade Federal de Viçosa (UFV) |
instacron_str |
UFV |
institution |
UFV |
reponame_str |
LOCUS Repositório Institucional da UFV |
collection |
LOCUS Repositório Institucional da UFV |
repository.name.fl_str_mv |
LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV) |
repository.mail.fl_str_mv |
fabiojreis@ufv.br |
_version_ |
1817559889516429312 |