Estado inflamatório e sua associação com os componentes da síndrome metabólica em adultos jovens

• Autor(a) principal: Volp, Ana Carolina Pinheiro
• Data de Publicação: 2009
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/444
• topic: Inflamação; Obesidade; Síndrome metabólica; Inflammation; Obesity; Metabolic syndrome; CNPQ::CIENCIAS AGRARIAS::CIENCIA E TECNOLOGIA DE ALIMENTOS::CIENCIA DE ALIMENTOS

The adipose tissue secret several adipokines, which may play important role in the genesis of metabolic syndrome (MS). In this view, several inflammation biomarkers have been studied, but there is a greater need to understand the inflammatory status in healthy young adult population, as well as their ability to predict the SM in this population. Thus, the aim of this study was evaluate the associations between concentrations of inflammatory biomarkers complement C3, adiponectin and C-reactive protein (CRP) with several anthropometrical, biochemical, dietary and lifestyle features, with special emphasis on the components of metabolic syndrome (MS) in apparently healthy young adults. This study enrolled 157 healthy young adults aged 18-35 years. Anthropometric and body composition, blood pressure, dietary and lifestyle features were collected and analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, insulin, complement C3, adiponectin, CRP, uric acid and ceruloplasmin concentrations. After that, anthropometrical, biochemical and diet quality indexes were calculated and analyzed. Complement C3 concentrations did not differ between genders (p=0.2433), but were higher for the group with overweight/obesity, when compared to the group with low weight/normal weight (p=0.0003). Adiponectin concentrations did not differ between the low weight/normal weight and the overweight/obesity groups (p=0.2028), but were significantly higher for women, when compared to men (p<0.0001). CRP concentrations were significantly higher for women, when compared to men (p=0.0006) and higher for the group with overweight/obesity, as compared to low weight /normal weight (p=0.0102). The complement C3 concentrations correlated (p<0.05) with BMI (r=0.23417), body fat percentage estimated by bioelectrical impedance (BEI) (r=0.29819), waist circumference (r=0.21266), insulin (r=0.26152), HOMA-IR (r=0.24831) and triglycerides (r=0.38435). Adiponectin concentrations correlated (p<0.05) with body fat percentage estimated by BEI (r=0.30145), BMI (r=-0.17810), waist circumference (r=-0.21199), systolic blood pressure (r=-0.20279), and HDL-c (r=0.53289). CRP concentrations correlated (p<0.05) with BMI (r=0.16147), body fat percentage estimated by BEI (r=0.41865), waist circumference (r=0.16487), insulin (r=0.19286), HOMA-IR (r=0.17055), triglycerides (r=0.39545) and glucose (r=- 0.20877). In multiple linear regression analysis, triglycerides (r2=0.1379, p<0.0001) and body fat estimated by BEI (r2=0.0621, p=0.0010) were associated in an independent way with complement C3 concentrations; HDL-c and uric acid (r2=0.3100, p<0.0001), tricipital skin fold thicknesses and waist circumference (r2=0.2245, p<0.0001) and consumption of alcohol, phosphorus and retinol (r2=0.1275, p=0.0003) were associated in an independent way with adiponectin concentrations; and the insulin and ceruloplasmin (r2=0.3044, p<0,0001), tricipital skin fold thicknesses (r2=0.1267, p<0,0001) and sodium consumption (r2=0.0425, p=0,0216) were associated in an independent way with CRP concentrations, both so regardless of age, gender, smoking and physical activity. Also, in multiple linear regression with only the components of the metabolic syndrome (MS), triglycerides (r2=0.1379, p<0.0001) were associated in an independent way with complement C3 concentrations; the HDL-c (r2=0.2840, p<0.0001) were associated in an independent way with adiponectin concentrations; and the triglycerides (p=0.0080) were associated with CRP concentrations, even after adjustment for BMI and body fat (%) estimated by BEI. Finally, for this sample of volunteers, for each increase of 10.0 mg/dL complement C3 concentrations, there is an increased chance of 76%, 54% and 40% of present high waist circumference, excess body weight and excess body fat; for each increase of 1.0 &#956;g/mL adiponectin concentrations, there is an increased chance of 91% and 22% of present reduced HDL-c and MS (p<0.05); and for each increase of 0.1mg/dL CRP concentrations, there is an increased chance of 3%, 30% and 2% of hipertriglyceridemia, body weigh excess and body fat excess (p<0.05). Thus, complement C3, adiponectin and CRP are related with anthropometric measurements and body composition as well biochemical, dietary and lifestyle features in apparently healthy young people. These findings demonstrate; (a) an independent role of triglycerides, component of MS, and body fat as predictors of complement C3 concentrations; (b) an independent role of HDL-cholesterol, component of MS, as predictors of adiponectin concentrations; and (c) an role of triglycerides, component of MS, as predictor of CRP concentrations. Thus, CRP can be used as an early marker of MS. On the other hand: (d) the ability of complement C3 in predicting chance to present high waist circumference, body weigh excess and body fat excess, (e) the ability of adiponectin in predicting chance to present low HDL-cholesterol and SM, and (f) the ability of CRP in predicting chance to present hypertriglyceridaemia, body weigh excess and body fat excess. Thus, the complement C3, a PCR and particularly adiponectin, can be used as early markers of MS.