Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal
Autor(a) principal: | |
---|---|
Data de Publicação: | 2008 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | http://locus.ufv.br/handle/123456789/2698 |
Resumo: | The subclinical chronic inflammation is confirmed as a new syndrome related to the development of insulin resistance. The fat tissue appears as important organ responsible for the increased expression of inflammatory substances, contributing to the development of this syndrome. This condition in adolescents with excess body fat is little known. The aim of this study was to evaluate the inflammatory profile of adolescents in overweight female post-pubescent, in those metabolic obese normal weight adolescents resistant to insulin. It was also a goal to verify the relationship between peripheral expression of mediators TNF-alpha, IL-6 and IL-10 and the parameters related to metabolic syndrome. 72 female adolescents in post-pubescent were evaluated, 14 to 17 years old. They were divided into 3 groups: eutrophic (G1), metabolic obese normal weight (G2) and overweight (G3). Data related to the parameters of the metabolic syndrome were collected: waist circumference, fasting plasma glucose, fasting insulin, insulin resistance, triglycerides, HDL, systolic and diastolic blood pressure. After the measurement of biochemical parameters, 10 overweight adolescents which were not insulin resistant were selected and those formed the control group (Si), and 10 overweight adolescents with insulin resistance were also chosen (Ri). It was evaluated the expression of mediators TNF-alpha, IL-6 and IL-10 in groups of study, and the correlation of these cytokines with the parameters of the metabolic syndrome. It was observed that G2 had intermediary values of weight, IMC and %GC in comparison to G1 and G3. Glicemia and insulin resistance were increased in G2 in comparison to G1, not differing of the G3. Insulinemia was increased and HDL was decreased in G2 in comparison to G3. Evaluating the peripheral expression of citocinas of G2 and G3 in comparison to G1, G3 had increase of 6% and 31% in expression of TNF-α and IL-10, respectively, and G2 had increase of 44% in expression of IL-6, without differences in the expression of cytokines between G2 and G3. There was positive correlation between TNF-α and IL-6, and between IL-10 and pro-inflammatory cytokines in the adolescents of G2, and in the adolescents with excess of body fat (G2 + G3), and positive correlation between IL-6 and glicemia (G2 group), and between IL-6 and triglycerides (G3 group). Considering overweight adolescents, there was no difference in the expression of cytokines evaluated among Si and Ri groups, although peripheric expression of IL-10 in the Ri group was 370% larger, regarding the Si group. In the adolescents of the Si group, IL-6 was positively correlated with IL-10, and negatively with insulinemia. IL-10 was negatively correlated with fast glicemia in the Si group. In the Ri group, there was no correlation between expression of cytokines and the parameters related with the metabolic syndrome. In the present study, Metabolic obese normal weight adolescents had metabolic profile, inflammatory profile and body composition similar to adolescents with overweight. It demonstrated the possible relation between IL-6 and glicemia and triglycerides. The positive correlations between IL-10 and TNF-α, IL-10 and IL-6, as well as the increased expression of IL-10 in overweigh adolescents regarding the eutrophic, suggests an attempt to inhibition the production of these citocinas by IL-10. Overweight adolescents with insulin resistance had similar peripehric expression to those overweight adolescents without insulin resistance. The increase of IL-10, and their negative correlation with fast glicêmica, can indicate possible protective paper of this cytokine in the development of cardiovascular risk factors. |
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Carvalho, Gisele Queirozhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4252798U7Priore, Sílvia Eloizahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4766931D6Paula, Sérgio Oliveira dehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4767540P4Peluzio, Maria do Carmo Gouveiahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723914H4Leite, Jacqueline Isaura Alvarezhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723009A8Ribeiro, Sônia Machado Rochahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701461E02015-03-26T13:11:41Z2009-05-062015-03-26T13:11:41Z2008-10-03CARVALHO, Gisele Queiroz. Study of some inflammatory markers and metabolic syndrome in overweight adolescents and in those metabolic obese normal weight. 2008. 5 f. Dissertação (Mestrado em Valor nutricional de alimentos e de dietas; Nutrição nas enfermidades agudas e crônicas não transmis) - Universidade Federal de Viçosa, Viçosa, 2008.http://locus.ufv.br/handle/123456789/2698The subclinical chronic inflammation is confirmed as a new syndrome related to the development of insulin resistance. The fat tissue appears as important organ responsible for the increased expression of inflammatory substances, contributing to the development of this syndrome. This condition in adolescents with excess body fat is little known. The aim of this study was to evaluate the inflammatory profile of adolescents in overweight female post-pubescent, in those metabolic obese normal weight adolescents resistant to insulin. It was also a goal to verify the relationship between peripheral expression of mediators TNF-alpha, IL-6 and IL-10 and the parameters related to metabolic syndrome. 72 female adolescents in post-pubescent were evaluated, 14 to 17 years old. They were divided into 3 groups: eutrophic (G1), metabolic obese normal weight (G2) and overweight (G3). Data related to the parameters of the metabolic syndrome were collected: waist circumference, fasting plasma glucose, fasting insulin, insulin resistance, triglycerides, HDL, systolic and diastolic blood pressure. After the measurement of biochemical parameters, 10 overweight adolescents which were not insulin resistant were selected and those formed the control group (Si), and 10 overweight adolescents with insulin resistance were also chosen (Ri). It was evaluated the expression of mediators TNF-alpha, IL-6 and IL-10 in groups of study, and the correlation of these cytokines with the parameters of the metabolic syndrome. It was observed that G2 had intermediary values of weight, IMC and %GC in comparison to G1 and G3. Glicemia and insulin resistance were increased in G2 in comparison to G1, not differing of the G3. Insulinemia was increased and HDL was decreased in G2 in comparison to G3. Evaluating the peripheral expression of citocinas of G2 and G3 in comparison to G1, G3 had increase of 6% and 31% in expression of TNF-α and IL-10, respectively, and G2 had increase of 44% in expression of IL-6, without differences in the expression of cytokines between G2 and G3. There was positive correlation between TNF-α and IL-6, and between IL-10 and pro-inflammatory cytokines in the adolescents of G2, and in the adolescents with excess of body fat (G2 + G3), and positive correlation between IL-6 and glicemia (G2 group), and between IL-6 and triglycerides (G3 group). Considering overweight adolescents, there was no difference in the expression of cytokines evaluated among Si and Ri groups, although peripheric expression of IL-10 in the Ri group was 370% larger, regarding the Si group. In the adolescents of the Si group, IL-6 was positively correlated with IL-10, and negatively with insulinemia. IL-10 was negatively correlated with fast glicemia in the Si group. In the Ri group, there was no correlation between expression of cytokines and the parameters related with the metabolic syndrome. In the present study, Metabolic obese normal weight adolescents had metabolic profile, inflammatory profile and body composition similar to adolescents with overweight. It demonstrated the possible relation between IL-6 and glicemia and triglycerides. The positive correlations between IL-10 and TNF-α, IL-10 and IL-6, as well as the increased expression of IL-10 in overweigh adolescents regarding the eutrophic, suggests an attempt to inhibition the production of these citocinas by IL-10. Overweight adolescents with insulin resistance had similar peripehric expression to those overweight adolescents without insulin resistance. The increase of IL-10, and their negative correlation with fast glicêmica, can indicate possible protective paper of this cytokine in the development of cardiovascular risk factors.A inflamação crônica subclínica se configura como nova síndrome relacionada com o desenvolvimento da resistência insulínica. O tecido adiposo aparece como importante órgão responsável pelo aumento da expressão de substâncias inflamatórias, contribuindo para o desenvolvimento desta síndrome. Pouco se sabe sobre essa condição em adolescentes com excesso de gordura corporal. O objetivo este estudo foi avaliar o perfil inflamatório de adolescentes do gênero feminino póspúberes com sobrepeso e nas metabolicamente obesas de peso normal , e de adolescentes com sobrepeso resistentes à insulina. Também foi intuito verificar a relação entre a expressão periférica dos mediadores TNF-α, IL-6 e IL-10 e os parâmetros relacionados com a síndrome metabólica. Foram avaliadas 72 adolescentes do gênero feminino pós-púberes, de 14 a 17 anos de idade, divididas em 3 grupos: eutróficas (G1), metabolicamente obesas de peso normal (G2) e sobrepeso (G3). Coletaram-se dados relacionados aos parâmetros da síndrome metabólica: circunferência da cintura, glicemia de jejum, insulinemia de jejum, resistência insulínica, triglicerídeos, HDL, pressão arterial sistólica e diastólica. Após a aferição dos parâmetros bioquímicos, do grupo de adolescentes com sobrepeso foram selecionadas 10 adolescentes sem resistência insulínica, as quais constituíam o grupo controle (Si), e 10 adolescentes com resistência insulínica (Ri). Avaliou-se a expressão dos mediadores TNF-α, IL-6 e IL-10 nos grupos de estudo, e a correlação desses mediadores com os parâmetros da síndrome metabólica. Foi possível constatar que G2 apresentou valores intermediários de peso, IMC e %GC em comparação com G1 e G3. Maiores valores de glicemia e de resistência insulínica foram verificados no G2 em relação ao G1, não diferindo do G3. G2 apresentou maiores valores de insulinemia e menores de HDL que G3. Avaliando-se a expressão periférica das citocinas do G2 e G3 em relação ao G1, G3 apresentou aumento na expressão de TNF-α e IL-10 de 6% e 31%, respectivamente, e o G2 apresentou aumento de 44% na expressão de IL-6, não havendo diferenças na expressão das citocinas entre G2 e G3. Verificou-se correlação positiva entre TNF-α e IL-6, e entre IL-10 e as citocinas pró-inflamatórias nas adolescentes do G2, e nas adolescentes com excesso de gordura corporal (G2 + G3), e correlação positiva entre a IL-6 e glicemia (grupo G2), e entre IL-6 e triglicerídeos (grupo G3). Em relação às adolescentes com sobrepeso, não houve diferença na expressão das citocinas avaliadas entre os grupos Si e Ri, embora a expressão periférica de IL-10 no grupo Ri tenha apresentado-se 370% maior, em relação ao grupo Si. Nas adolescentes do grupo Si, IL-6 correlacionou-se positivamente com IL-10, e negativamente com a insulinemia. IL-10 correlacionouse negativamente com glicemia de jejum no grupo Si. No grupo Ri, não houve correlação entre a expressão de citocinas e os parâmetros relacionados com a síndrome metabólica. No presente estudo, adolescentes metabolicamente obesas de peso normal apresentaram perfil metabólico, inflamatório e de composição corporal semelhante à de adolescentes com sobrepeso. Demonstrou-se possível relação entre IL-6 e glicemia e triglicerídeos. A correlação positiva entre IL-10 e TNF-α e IL- 6, bem como a maior expressão de IL-10 nas adolescentes com sobrepeso em relação às eutróficas, sugere tentativa de inibição da produção dessas citocinas pela IL-10. Nas adolescentes com sobrepeso, aquelas resistentes à insulina apresentaram expressão periférica dos marcadores inflamatórios semelhante àquelas com excesso de peso sem resistência insulínica. O aumento da IL-10, e sua correlação negativa com a glicemia de jejum, indica possível papel protetor desta citocina no desenvolvimento de fatores de risco cardiovasculares.Fundação de Amparo a Pesquisa do Estado de Minas Geraisapplication/pdfporUniversidade Federal de ViçosaMestrado em Ciência da NutriçãoUFVBRValor nutricional de alimentos e de dietas; Nutrição nas enfermidades agudas e crônicas não transmisSíndrome metabólicaObesidadeAdolescentesMetabolismoResistência à insulinaMetabolic syndromeObesityAdolescentsMetabolismInsulin resistanceCNPQ::CIENCIAS DA SAUDE::NUTRICAOEstudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normalStudy of some inflammatory markers and metabolic syndrome in overweight adolescents and in those metabolic obese normal weightinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINAL01 - capa_abstract.pdfapplication/pdf87047https://locus.ufv.br//bitstream/123456789/2698/1/01%20-%20capa_abstract.pdfadc8f126a08b82c40f01ada209b2c4b2MD51TEXT01 - capa_abstract.pdf.txt01 - capa_abstract.pdf.txtExtracted texttext/plain9128https://locus.ufv.br//bitstream/123456789/2698/2/01%20-%20capa_abstract.pdf.txtda2e6f223cd9998a24fa9e8594db8673MD52THUMBNAIL01 - capa_abstract.pdf.jpg01 - capa_abstract.pdf.jpgIM Thumbnailimage/jpeg3801https://locus.ufv.br//bitstream/123456789/2698/3/01%20-%20capa_abstract.pdf.jpg606ef350381ed287d0a4875d9a13bac9MD53123456789/26982016-04-07 23:14:19.967oai:locus.ufv.br:123456789/2698Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452016-04-08T02:14:19LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.por.fl_str_mv |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal |
dc.title.alternative.eng.fl_str_mv |
Study of some inflammatory markers and metabolic syndrome in overweight adolescents and in those metabolic obese normal weight |
title |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal |
spellingShingle |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal Carvalho, Gisele Queiroz Síndrome metabólica Obesidade Adolescentes Metabolismo Resistência à insulina Metabolic syndrome Obesity Adolescents Metabolism Insulin resistance CNPQ::CIENCIAS DA SAUDE::NUTRICAO |
title_short |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal |
title_full |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal |
title_fullStr |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal |
title_full_unstemmed |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal |
title_sort |
Estudo de alguns marcadores inflamatórios e de síndrome metabólica em adolescentes com sobrepeso e naquelas metabolicamente obesas de peso normal |
author |
Carvalho, Gisele Queiroz |
author_facet |
Carvalho, Gisele Queiroz |
author_role |
author |
dc.contributor.authorLattes.por.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4252798U7 |
dc.contributor.author.fl_str_mv |
Carvalho, Gisele Queiroz |
dc.contributor.advisor-co1.fl_str_mv |
Priore, Sílvia Eloiza |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4766931D6 |
dc.contributor.advisor-co2.fl_str_mv |
Paula, Sérgio Oliveira de |
dc.contributor.advisor-co2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4767540P4 |
dc.contributor.advisor1.fl_str_mv |
Peluzio, Maria do Carmo Gouveia |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723914H4 |
dc.contributor.referee1.fl_str_mv |
Leite, Jacqueline Isaura Alvarez |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4723009A8 |
dc.contributor.referee2.fl_str_mv |
Ribeiro, Sônia Machado Rocha |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701461E0 |
contributor_str_mv |
Priore, Sílvia Eloiza Paula, Sérgio Oliveira de Peluzio, Maria do Carmo Gouveia Leite, Jacqueline Isaura Alvarez Ribeiro, Sônia Machado Rocha |
dc.subject.por.fl_str_mv |
Síndrome metabólica Obesidade Adolescentes Metabolismo Resistência à insulina |
topic |
Síndrome metabólica Obesidade Adolescentes Metabolismo Resistência à insulina Metabolic syndrome Obesity Adolescents Metabolism Insulin resistance CNPQ::CIENCIAS DA SAUDE::NUTRICAO |
dc.subject.eng.fl_str_mv |
Metabolic syndrome Obesity Adolescents Metabolism Insulin resistance |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::NUTRICAO |
description |
The subclinical chronic inflammation is confirmed as a new syndrome related to the development of insulin resistance. The fat tissue appears as important organ responsible for the increased expression of inflammatory substances, contributing to the development of this syndrome. This condition in adolescents with excess body fat is little known. The aim of this study was to evaluate the inflammatory profile of adolescents in overweight female post-pubescent, in those metabolic obese normal weight adolescents resistant to insulin. It was also a goal to verify the relationship between peripheral expression of mediators TNF-alpha, IL-6 and IL-10 and the parameters related to metabolic syndrome. 72 female adolescents in post-pubescent were evaluated, 14 to 17 years old. They were divided into 3 groups: eutrophic (G1), metabolic obese normal weight (G2) and overweight (G3). Data related to the parameters of the metabolic syndrome were collected: waist circumference, fasting plasma glucose, fasting insulin, insulin resistance, triglycerides, HDL, systolic and diastolic blood pressure. After the measurement of biochemical parameters, 10 overweight adolescents which were not insulin resistant were selected and those formed the control group (Si), and 10 overweight adolescents with insulin resistance were also chosen (Ri). It was evaluated the expression of mediators TNF-alpha, IL-6 and IL-10 in groups of study, and the correlation of these cytokines with the parameters of the metabolic syndrome. It was observed that G2 had intermediary values of weight, IMC and %GC in comparison to G1 and G3. Glicemia and insulin resistance were increased in G2 in comparison to G1, not differing of the G3. Insulinemia was increased and HDL was decreased in G2 in comparison to G3. Evaluating the peripheral expression of citocinas of G2 and G3 in comparison to G1, G3 had increase of 6% and 31% in expression of TNF-α and IL-10, respectively, and G2 had increase of 44% in expression of IL-6, without differences in the expression of cytokines between G2 and G3. There was positive correlation between TNF-α and IL-6, and between IL-10 and pro-inflammatory cytokines in the adolescents of G2, and in the adolescents with excess of body fat (G2 + G3), and positive correlation between IL-6 and glicemia (G2 group), and between IL-6 and triglycerides (G3 group). Considering overweight adolescents, there was no difference in the expression of cytokines evaluated among Si and Ri groups, although peripheric expression of IL-10 in the Ri group was 370% larger, regarding the Si group. In the adolescents of the Si group, IL-6 was positively correlated with IL-10, and negatively with insulinemia. IL-10 was negatively correlated with fast glicemia in the Si group. In the Ri group, there was no correlation between expression of cytokines and the parameters related with the metabolic syndrome. In the present study, Metabolic obese normal weight adolescents had metabolic profile, inflammatory profile and body composition similar to adolescents with overweight. It demonstrated the possible relation between IL-6 and glicemia and triglycerides. The positive correlations between IL-10 and TNF-α, IL-10 and IL-6, as well as the increased expression of IL-10 in overweigh adolescents regarding the eutrophic, suggests an attempt to inhibition the production of these citocinas by IL-10. Overweight adolescents with insulin resistance had similar peripehric expression to those overweight adolescents without insulin resistance. The increase of IL-10, and their negative correlation with fast glicêmica, can indicate possible protective paper of this cytokine in the development of cardiovascular risk factors. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-10-03 |
dc.date.available.fl_str_mv |
2009-05-06 2015-03-26T13:11:41Z |
dc.date.accessioned.fl_str_mv |
2015-03-26T13:11:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, Gisele Queiroz. Study of some inflammatory markers and metabolic syndrome in overweight adolescents and in those metabolic obese normal weight. 2008. 5 f. Dissertação (Mestrado em Valor nutricional de alimentos e de dietas; Nutrição nas enfermidades agudas e crônicas não transmis) - Universidade Federal de Viçosa, Viçosa, 2008. |
dc.identifier.uri.fl_str_mv |
http://locus.ufv.br/handle/123456789/2698 |
identifier_str_mv |
CARVALHO, Gisele Queiroz. Study of some inflammatory markers and metabolic syndrome in overweight adolescents and in those metabolic obese normal weight. 2008. 5 f. Dissertação (Mestrado em Valor nutricional de alimentos e de dietas; Nutrição nas enfermidades agudas e crônicas não transmis) - Universidade Federal de Viçosa, Viçosa, 2008. |
url |
http://locus.ufv.br/handle/123456789/2698 |
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por |
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por |
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Universidade Federal de Viçosa |
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Mestrado em Ciência da Nutrição |
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UFV |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Valor nutricional de alimentos e de dietas; Nutrição nas enfermidades agudas e crônicas não transmis |
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Universidade Federal de Viçosa |
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