Autoenxerto da crista ilíaca, associado ou não à medula óssea autógena, na promoção de união vertebral dorsolateral lombar em coelhos

• Autor(a) principal: Silva, Alessandra Sayegh Arreguy
• Data de Publicação: 2003
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/5167
• topic: Autoenxerto ósseo; Coluna vertebral; Fusão espinhal; Bone autograft; Spine; Vertebral union; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL

In this study, two experiments were conducted in order to evaluate the iliac crest autograft and this association to fresh autogenous bone marrow in the lumbar dorsolateral vertebral union in rabbits. Thirty-three animals, separated in two groups, were used in each experiment. Nine animals in group 1 (G1), corresponding to the control group, where only L5-L6 transverses processes decortications were created and twenty-four animals in group 2 (G2) where, besides the decortication, the graft material was also deposited on L5-L6 transverses processes. The anesthetic protocol and surgical technique were the same in both works, difering the graft material used. In the first work, only the iliac crest autograft was associated to 2 millimeters of fresh autogenous bone graft. Manual palpations, radiographic, histological and biomechanical evaluations of the operated segments (L5-L6) and adjacents (L4-L5 and L6-L7); the solid segments were classified as solid union. The radiographics analysis was based on the presence of bone mass, bilaterally, without the interlaminar space was the object of study in histological analysis as the type of predominant tissue; and during the biomechanical test the force and resistence of vertebral union were evaluated. The manual palpation and radiographics evaluations demonstrated do not be the method of choice to determine the vertebral union level due to the great variation observed in the results comparing to histological and biomechanical analysis. In the histological analysis it was possible to observe the bone formation sequence from the reabsorption of bone fragments graft, the intense periosteal reaction over the decorticated transverse processes until the bone integration andconsequent vertebral union. In the biomechanical test, the force and rigidity of the operated segments were bigger than adjacents vertebras, although this diference was not significant throughout the analysis. In the first work, it was observed that the autogenous iliac crest bone graft when used in adequate amounts conduced to vertebral union in rabbits, which was intensified nine weeks after the surgical procedure. In the second work, the fresh autograft bone marrow associated to the iliac crest bone graft anticipate the bone formation which began at five weeks after surgery consisting an option for those patients whose sufficient bone graft amount can not be obtained to induce vertebral fusion.