Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://doi.org/10.1016/j.bjm.2016.06.006 http://www.locus.ufv.br/handle/123456789/12629 |
Resumo: | Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments. |
id |
UFV_f7bc39242586d11ea0617549a5f4fc59 |
---|---|
oai_identifier_str |
oai:locus.ufv.br:123456789/12629 |
network_acronym_str |
UFV |
network_name_str |
LOCUS Repositório Institucional da UFV |
repository_id_str |
2145 |
spelling |
Spolti, PierriDel Ponte, Emerson MedeirosRibas, Aícha Daniela Ribas eDonato, Katarzyna ZawadaSchrekker, HenriFuentefria, Alexandre Meneghello2017-10-31T15:28:10Z2017-10-31T15:28:10Z2016-07-071517-8382https://doi.org/10.1016/j.bjm.2016.06.006http://www.locus.ufv.br/handle/123456789/12629Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments.porBrazilian Journal of MicrobiologyVolume 47, Issue 4, Pages 793-799, October–December 2016Cross-resistanceEmerging fungal pathogensFungicide sensitivityAgriculture MedicineIs the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINAL1-s2.0-S1517838216305342-main.pdf1-s2.0-S1517838216305342-main.pdftexto completoapplication/pdf1384915https://locus.ufv.br//bitstream/123456789/12629/1/1-s2.0-S1517838216305342-main.pdf30e6145f152ea50d46f128571b43a29aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/12629/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAIL1-s2.0-S1517838216305342-main.pdf.jpg1-s2.0-S1517838216305342-main.pdf.jpgIM Thumbnailimage/jpeg3457https://locus.ufv.br//bitstream/123456789/12629/3/1-s2.0-S1517838216305342-main.pdf.jpg9e42fa696d2d46a393398fd7ec7f0c53MD53123456789/126292018-03-22 08:37:43.325oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-03-22T11:37:43LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
spellingShingle |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review Spolti, Pierri Cross-resistance Emerging fungal pathogens Fungicide sensitivity Agriculture Medicine |
title_short |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_full |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_fullStr |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_full_unstemmed |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
title_sort |
Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review |
author |
Spolti, Pierri |
author_facet |
Spolti, Pierri Del Ponte, Emerson Medeiros Ribas, Aícha Daniela Ribas e Donato, Katarzyna Zawada Schrekker, Henri Fuentefria, Alexandre Meneghello |
author_role |
author |
author2 |
Del Ponte, Emerson Medeiros Ribas, Aícha Daniela Ribas e Donato, Katarzyna Zawada Schrekker, Henri Fuentefria, Alexandre Meneghello |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Spolti, Pierri Del Ponte, Emerson Medeiros Ribas, Aícha Daniela Ribas e Donato, Katarzyna Zawada Schrekker, Henri Fuentefria, Alexandre Meneghello |
dc.subject.pt-BR.fl_str_mv |
Cross-resistance Emerging fungal pathogens Fungicide sensitivity Agriculture Medicine |
topic |
Cross-resistance Emerging fungal pathogens Fungicide sensitivity Agriculture Medicine |
description |
Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple fungicides and contributing to the perpetuation of resistant strains in the environment. The emergence of fungicide-resistant isolates of human pathogens has been related to the exposure to fungicides used in agroecosystems. Examples include species of cosmopolitan occurrence, such as Fusarium and Aspergillus, which cause diseases in both plants and humans. This review summarizes the information about the most important triazole fungicides that are largely used in human clinical therapy and agriculture. We aim to discuss the issues related to fungicide resistance and the recommended strategies for preventing the emergence of triazole-resistant fungal populations capable of spreading across environments. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-07-07 |
dc.date.accessioned.fl_str_mv |
2017-10-31T15:28:10Z |
dc.date.available.fl_str_mv |
2017-10-31T15:28:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1016/j.bjm.2016.06.006 http://www.locus.ufv.br/handle/123456789/12629 |
dc.identifier.issn.none.fl_str_mv |
1517-8382 |
identifier_str_mv |
1517-8382 |
url |
https://doi.org/10.1016/j.bjm.2016.06.006 http://www.locus.ufv.br/handle/123456789/12629 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartofseries.pt-BR.fl_str_mv |
Volume 47, Issue 4, Pages 793-799, October–December 2016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journal of Microbiology |
publisher.none.fl_str_mv |
Brazilian Journal of Microbiology |
dc.source.none.fl_str_mv |
reponame:LOCUS Repositório Institucional da UFV instname:Universidade Federal de Viçosa (UFV) instacron:UFV |
instname_str |
Universidade Federal de Viçosa (UFV) |
instacron_str |
UFV |
institution |
UFV |
reponame_str |
LOCUS Repositório Institucional da UFV |
collection |
LOCUS Repositório Institucional da UFV |
bitstream.url.fl_str_mv |
https://locus.ufv.br//bitstream/123456789/12629/1/1-s2.0-S1517838216305342-main.pdf https://locus.ufv.br//bitstream/123456789/12629/2/license.txt https://locus.ufv.br//bitstream/123456789/12629/3/1-s2.0-S1517838216305342-main.pdf.jpg |
bitstream.checksum.fl_str_mv |
30e6145f152ea50d46f128571b43a29a 8a4605be74aa9ea9d79846c1fba20a33 9e42fa696d2d46a393398fd7ec7f0c53 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV) |
repository.mail.fl_str_mv |
fabiojreis@ufv.br |
_version_ |
1801213087467962368 |