Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Psicologia (Universidade de Brasília. Online) |
Texto Completo: | https://periodicos.unb.br/index.php/revistaptp/article/view/17578 |
Resumo: | In the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies. The results indicate simultaneous modulation of behavior and antibody production by fluoxetine. |
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Psicologia (Universidade de Brasília. Online) |
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Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced SwimmingEfeitos Comportamentais e Imunológicos da Fluoxetina em Ratos Submetidos ao Nado ForçadoCiências Humanas/Psicologia/PsicobiologiaImunomodulaçãoMassa corporalNado forçadoFluoxetinaImmunomodulationBody weightForced swimmingFluoxetineIn the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies. The results indicate simultaneous modulation of behavior and antibody production by fluoxetine.Evidências sugerem que a depressão envolve alterações imunológicas. No presente trabalho, os efeitos comportamentais e imunomoduladores de um antidepressivo, a fluoxetina, são avaliados num modelo animal de depressão, o nado forçado. Nesse modelo, o comportamento de flutuar é usado como índice de desespero comportamental. Ratos foram tratados por 12 dias com fluoxetina (10mg/kg) três vezes ao dia ou com salina; e, nos mesmos dias, foram submetidos a sessões de nado forçado. Adicionalmente, a resposta imune humoral a uma imunoestimulação foi avaliada. Os animais tratados com fluoxetina apresentaram menor produção total de anticorpos e queda de massa corporal, além de passarem mais tempo flutuando. Os resultados sugerem que o desespero comportamental e a produção de anticorpos são simultaneamente atenuados pela fluoxetina.Instituto de Psicologia - Universidade de Brasília2012-12-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.unb.br/index.php/revistaptp/article/view/17578Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415Psicologia: Teoria e Pesquisa; Vol. 28 Núm. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415Psicologia: Teoria e Pesquisa; v. 28 n. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-4151806-34460102-3772reponame:Psicologia (Universidade de Brasília. Online)instname:Universidade de Brasília (UnB)instacron:UNBporhttps://periodicos.unb.br/index.php/revistaptp/article/view/17578/16090https://periodicos.unb.br/index.php/revistaptp/article/view/17578/16932Fernandes, Eduardo VignotoRamos, Solange de PaulaEstanislau, CelioVenancio, Emerson Joséinfo:eu-repo/semantics/openAccess2018-10-25T17:29:48Zoai:ojs.pkp.sfu.ca:article/17578Revistahttps://periodicos.unb.br/index.php/revistaptp/indexPUBhttps://periodicos.unb.br/index.php/revistaptp/oairevistaptp@gmail.com1806-34460102-3772opendoar:2018-10-25T17:29:48Psicologia (Universidade de Brasília. Online) - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming Efeitos Comportamentais e Imunológicos da Fluoxetina em Ratos Submetidos ao Nado Forçado |
title |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming |
spellingShingle |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming Fernandes, Eduardo Vignoto Ciências Humanas/Psicologia/Psicobiologia Imunomodulação Massa corporal Nado forçado Fluoxetina Immunomodulation Body weight Forced swimming Fluoxetine |
title_short |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming |
title_full |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming |
title_fullStr |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming |
title_full_unstemmed |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming |
title_sort |
Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming |
author |
Fernandes, Eduardo Vignoto |
author_facet |
Fernandes, Eduardo Vignoto Ramos, Solange de Paula Estanislau, Celio Venancio, Emerson José |
author_role |
author |
author2 |
Ramos, Solange de Paula Estanislau, Celio Venancio, Emerson José |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Fernandes, Eduardo Vignoto Ramos, Solange de Paula Estanislau, Celio Venancio, Emerson José |
dc.subject.por.fl_str_mv |
Ciências Humanas/Psicologia/Psicobiologia Imunomodulação Massa corporal Nado forçado Fluoxetina Immunomodulation Body weight Forced swimming Fluoxetine |
topic |
Ciências Humanas/Psicologia/Psicobiologia Imunomodulação Massa corporal Nado forçado Fluoxetina Immunomodulation Body weight Forced swimming Fluoxetine |
description |
In the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies. The results indicate simultaneous modulation of behavior and antibody production by fluoxetine. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-12-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.unb.br/index.php/revistaptp/article/view/17578 |
url |
https://periodicos.unb.br/index.php/revistaptp/article/view/17578 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.unb.br/index.php/revistaptp/article/view/17578/16090 https://periodicos.unb.br/index.php/revistaptp/article/view/17578/16932 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Instituto de Psicologia - Universidade de Brasília |
publisher.none.fl_str_mv |
Instituto de Psicologia - Universidade de Brasília |
dc.source.none.fl_str_mv |
Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415 Psicologia: Teoria e Pesquisa; Vol. 28 Núm. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415 Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415 Psicologia: Teoria e Pesquisa; v. 28 n. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415 1806-3446 0102-3772 reponame:Psicologia (Universidade de Brasília. Online) instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
instacron_str |
UNB |
institution |
UNB |
reponame_str |
Psicologia (Universidade de Brasília. Online) |
collection |
Psicologia (Universidade de Brasília. Online) |
repository.name.fl_str_mv |
Psicologia (Universidade de Brasília. Online) - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
revistaptp@gmail.com |
_version_ |
1800211712314441728 |