Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming

Detalhes bibliográficos
Autor(a) principal: Fernandes, Eduardo Vignoto
Data de Publicação: 2012
Outros Autores: Ramos, Solange de Paula, Estanislau, Celio, Venancio, Emerson José
Tipo de documento: Artigo
Idioma: por
Título da fonte: Psicologia (Universidade de Brasília. Online)
Texto Completo: https://periodicos.unb.br/index.php/revistaptp/article/view/17578
Resumo: In the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies. The results indicate simultaneous modulation of behavior and antibody production by fluoxetine.
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spelling Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced SwimmingEfeitos Comportamentais e Imunológicos da Fluoxetina em Ratos Submetidos ao Nado ForçadoCiências Humanas/Psicologia/PsicobiologiaImunomodulaçãoMassa corporalNado forçadoFluoxetinaImmunomodulationBody weightForced swimmingFluoxetineIn the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies. The results indicate simultaneous modulation of behavior and antibody production by fluoxetine.Evidências sugerem que a depressão envolve alterações imunológicas. No presente trabalho, os efeitos comportamentais e imunomoduladores de um antidepressivo, a fluoxetina, são avaliados num modelo animal de depressão, o nado forçado. Nesse modelo, o comportamento de flutuar é usado como índice de desespero comportamental. Ratos foram tratados por 12 dias com fluoxetina (10mg/kg) três vezes ao dia ou com salina; e, nos mesmos dias, foram submetidos a sessões de nado forçado. Adicionalmente, a resposta imune humoral a uma imunoestimulação foi avaliada. Os animais tratados com fluoxetina apresentaram menor produção total de anticorpos e queda de massa corporal, além de passarem mais tempo flutuando. Os resultados sugerem que o desespero comportamental e a produção de anticorpos são simultaneamente atenuados pela fluoxetina.Instituto de Psicologia - Universidade de Brasília2012-12-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.unb.br/index.php/revistaptp/article/view/17578Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415Psicologia: Teoria e Pesquisa; Vol. 28 Núm. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415Psicologia: Teoria e Pesquisa; v. 28 n. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-4151806-34460102-3772reponame:Psicologia (Universidade de Brasília. Online)instname:Universidade de Brasília (UnB)instacron:UNBporhttps://periodicos.unb.br/index.php/revistaptp/article/view/17578/16090https://periodicos.unb.br/index.php/revistaptp/article/view/17578/16932Fernandes, Eduardo VignotoRamos, Solange de PaulaEstanislau, CelioVenancio, Emerson Joséinfo:eu-repo/semantics/openAccess2018-10-25T17:29:48Zoai:ojs.pkp.sfu.ca:article/17578Revistahttps://periodicos.unb.br/index.php/revistaptp/indexPUBhttps://periodicos.unb.br/index.php/revistaptp/oairevistaptp@gmail.com1806-34460102-3772opendoar:2018-10-25T17:29:48Psicologia (Universidade de Brasília. Online) - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
Efeitos Comportamentais e Imunológicos da Fluoxetina em Ratos Submetidos ao Nado Forçado
title Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
spellingShingle Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
Fernandes, Eduardo Vignoto
Ciências Humanas/Psicologia/Psicobiologia
Imunomodulação
Massa corporal
Nado forçado
Fluoxetina
Immunomodulation
Body weight
Forced swimming
Fluoxetine
title_short Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
title_full Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
title_fullStr Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
title_full_unstemmed Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
title_sort Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced Swimming
author Fernandes, Eduardo Vignoto
author_facet Fernandes, Eduardo Vignoto
Ramos, Solange de Paula
Estanislau, Celio
Venancio, Emerson José
author_role author
author2 Ramos, Solange de Paula
Estanislau, Celio
Venancio, Emerson José
author2_role author
author
author
dc.contributor.author.fl_str_mv Fernandes, Eduardo Vignoto
Ramos, Solange de Paula
Estanislau, Celio
Venancio, Emerson José
dc.subject.por.fl_str_mv Ciências Humanas/Psicologia/Psicobiologia
Imunomodulação
Massa corporal
Nado forçado
Fluoxetina
Immunomodulation
Body weight
Forced swimming
Fluoxetine
topic Ciências Humanas/Psicologia/Psicobiologia
Imunomodulação
Massa corporal
Nado forçado
Fluoxetina
Immunomodulation
Body weight
Forced swimming
Fluoxetine
description In the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies. The results indicate simultaneous modulation of behavior and antibody production by fluoxetine.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.unb.br/index.php/revistaptp/article/view/17578
url https://periodicos.unb.br/index.php/revistaptp/article/view/17578
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.unb.br/index.php/revistaptp/article/view/17578/16090
https://periodicos.unb.br/index.php/revistaptp/article/view/17578/16932
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto de Psicologia - Universidade de Brasília
publisher.none.fl_str_mv Instituto de Psicologia - Universidade de Brasília
dc.source.none.fl_str_mv Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415
Psicologia: Teoria e Pesquisa; Vol. 28 Núm. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415
Psicologia: Teoria e Pesquisa; Vol. 28 No. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415
Psicologia: Teoria e Pesquisa; v. 28 n. 4 (2012): Revista Psicologia: teoria e pesquisa; 409-415
1806-3446
0102-3772
reponame:Psicologia (Universidade de Brasília. Online)
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Psicologia (Universidade de Brasília. Online)
collection Psicologia (Universidade de Brasília. Online)
repository.name.fl_str_mv Psicologia (Universidade de Brasília. Online) - Universidade de Brasília (UnB)
repository.mail.fl_str_mv revistaptp@gmail.com
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