Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test

Detalhes bibliográficos
Autor(a) principal: Ciulla,Leandro
Data de Publicação: 2007
Outros Autores: Menezes,Honório Sampaio, Bueno,Bárbara Beatriz Moreira, Schuh,Alexandre, Alves,Rafael José Vargas, Abegg,Milena Pacheco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000500005
Resumo: PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.
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spelling Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming testPhysiological Effects of DrugsFluoxetineDepressionAnimal ExperimentationPURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2007-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000500005Acta Cirúrgica Brasileira v.22 n.5 2007reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502007000500005info:eu-repo/semantics/openAccessCiulla,LeandroMenezes,Honório SampaioBueno,Bárbara Beatriz MoreiraSchuh,AlexandreAlves,Rafael José VargasAbegg,Milena Pachecoeng2007-09-28T00:00:00Zoai:scielo:S0102-86502007000500005Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2007-09-28T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
title Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
spellingShingle Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
Ciulla,Leandro
Physiological Effects of Drugs
Fluoxetine
Depression
Animal Experimentation
title_short Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
title_full Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
title_fullStr Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
title_full_unstemmed Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
title_sort Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test
author Ciulla,Leandro
author_facet Ciulla,Leandro
Menezes,Honório Sampaio
Bueno,Bárbara Beatriz Moreira
Schuh,Alexandre
Alves,Rafael José Vargas
Abegg,Milena Pacheco
author_role author
author2 Menezes,Honório Sampaio
Bueno,Bárbara Beatriz Moreira
Schuh,Alexandre
Alves,Rafael José Vargas
Abegg,Milena Pacheco
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ciulla,Leandro
Menezes,Honório Sampaio
Bueno,Bárbara Beatriz Moreira
Schuh,Alexandre
Alves,Rafael José Vargas
Abegg,Milena Pacheco
dc.subject.por.fl_str_mv Physiological Effects of Drugs
Fluoxetine
Depression
Animal Experimentation
topic Physiological Effects of Drugs
Fluoxetine
Depression
Animal Experimentation
description PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. RESULTS: Rats given injections of fluoxetine displayed significantly less immobility (p = 0.02) and fewer stops than the control group (p = 0.003). Duloxetine significanlty reduced the number of stops (p = 0.003), but did not effect immobility (p = 0.48). CONCLUSION: Duloxetine and fluoxetine reduced depressive behaviors in the Forced FST. However, our findings suggest that fluoxetine is more effective than duloxetine.
publishDate 2007
dc.date.none.fl_str_mv 2007-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000500005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502007000500005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502007000500005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.22 n.5 2007
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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