Apolipoprotein and lipid abnormalities in chronic liver failure

Detalhes bibliográficos
Autor(a) principal: Spósito, Andrei Carvalho
Data de Publicação: 1997
Outros Autores: Vinagre, C.G., Pandullo, F.L., Mies, S., Raia, S., Ramires, José Antonio F.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/4028
Resumo: 4 f.
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spelling Apolipoprotein and lipid abnormalities in chronic liver failureFígado - doençasInsuficiência hepáticaHepatite BColesterolMetabolismo4 f.Total serum lipids, as well as apolipoproteins A-I (apo A-I) and B (apo B), were determined in 74 patients with chronic liver failure without cholestasis and in 82 normal subjects. The VLDL, LDL and HDL lipid fractions were reduced in the liver failure group by 36%, 24% and 46%, respectively (P<0.001). Apolipoproteins A-I and B were also reduced by 26% and 25%, respectively (P<0.001). However, the reduction of HDL cholesterol (HDLc) was more pronounced than that of apo A-I and the HDLc:apo A-I ratio was significantly lower in the liver failure group. After separating these patients into groups with plasma albumin lower than 3.0, between 3.0 and 3.5, and higher than 3.5 g/dl, the HDLc:apo A-I ratio was proportional to plasma albumin, but the correlation was not statistically significant. When these patients were separated by the Child classification of liver function, there was a correlation between the HDLc:apo A-I ratio and liver function. The differences in the HDLc:apo A-I ratio between the Child groups B and C, and A and C were statistically significant (P<0.05). We conclude that there is a more pronounced reduction in HDL cholesterol than in apo A-I in liver failure patients. Therefore, the HDLc:apo A-I ratio is a marker of liver function, probably because there is a decreased lecithin-cholesterol acyltransferase production by the diseased liver.Faculdade de Medicina (FM)2010-03-26T14:21:38Z2010-03-26T14:21:38Z1997-11info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSPOSITO, Andrei et al. Apolipoprotein and lipid abnormalities in chronic liver failure. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 30, n. 11, p. 1287-1290, nov. 1997. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100004&Ing=en&nrm=iso>. Acesso em: 16 mar. 2010.http://repositorio.unb.br/handle/10482/4028Spósito, Andrei CarvalhoVinagre, C.G.Pandullo, F.L.Mies, S.Raia, S.Ramires, José Antonio F.info:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-09-19T15:44:14Zoai:repositorio.unb.br:10482/4028Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-09-19T15:44:14Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Apolipoprotein and lipid abnormalities in chronic liver failure
title Apolipoprotein and lipid abnormalities in chronic liver failure
spellingShingle Apolipoprotein and lipid abnormalities in chronic liver failure
Spósito, Andrei Carvalho
Fígado - doenças
Insuficiência hepática
Hepatite B
Colesterol
Metabolismo
title_short Apolipoprotein and lipid abnormalities in chronic liver failure
title_full Apolipoprotein and lipid abnormalities in chronic liver failure
title_fullStr Apolipoprotein and lipid abnormalities in chronic liver failure
title_full_unstemmed Apolipoprotein and lipid abnormalities in chronic liver failure
title_sort Apolipoprotein and lipid abnormalities in chronic liver failure
author Spósito, Andrei Carvalho
author_facet Spósito, Andrei Carvalho
Vinagre, C.G.
Pandullo, F.L.
Mies, S.
Raia, S.
Ramires, José Antonio F.
author_role author
author2 Vinagre, C.G.
Pandullo, F.L.
Mies, S.
Raia, S.
Ramires, José Antonio F.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Spósito, Andrei Carvalho
Vinagre, C.G.
Pandullo, F.L.
Mies, S.
Raia, S.
Ramires, José Antonio F.
dc.subject.por.fl_str_mv Fígado - doenças
Insuficiência hepática
Hepatite B
Colesterol
Metabolismo
topic Fígado - doenças
Insuficiência hepática
Hepatite B
Colesterol
Metabolismo
description 4 f.
publishDate 1997
dc.date.none.fl_str_mv 1997-11
2010-03-26T14:21:38Z
2010-03-26T14:21:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SPOSITO, Andrei et al. Apolipoprotein and lipid abnormalities in chronic liver failure. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 30, n. 11, p. 1287-1290, nov. 1997. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100004&Ing=en&nrm=iso>. Acesso em: 16 mar. 2010.
http://repositorio.unb.br/handle/10482/4028
identifier_str_mv SPOSITO, Andrei et al. Apolipoprotein and lipid abnormalities in chronic liver failure. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 30, n. 11, p. 1287-1290, nov. 1997. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100004&Ing=en&nrm=iso>. Acesso em: 16 mar. 2010.
url http://repositorio.unb.br/handle/10482/4028
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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