Evaluation of the impact of serogroup C meningococcal disease vaccination program in Brazil and its regions : a population-based study, 2001-2013

• Autor(a) principal: Moraes, Camile de
• Data de Publicação: 2017
• Outros Autores: Moraes, José Cássio de, Silva, Gabriela Drummond Marques da, Duarte, Elisabeth Carmen
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UnB
• Texto Completo: http://repositorio.unb.br/handle/10482/30583; http://dx.doi.org/10.1590/0074-02760160173
• topic: Meningite; Prevenção; Vacinação

Background: meningococcal C conjugate (MenC) vaccine was introduced as part of the Brazilian National Immunisation Program in 2010 for children < 1 year of age. Objectives: the study objective was to evaluate the impact of this vaccination strategy. Methods: an observational, mixed ecological and analytical study was conducted, based on time series panel data from surveillance records (2001-2013). Findings: a total of 37,538 of meningococcal disease cases were recorded during the study period. Of these, 19,997 were attributed to serogroup C. A decrease in meningococcal disease serogroup C (MDC) incidence among children aged < 1 year [65.2%; 95% confidence interval (CI): 20.5-84.7%] and 1-4 years (46.9%; 95%CI: 14.6-79.1%) were found in the three years following vaccination introduction. Vaccination impact on the reduction of MDC incidence varied from 83.7% (95%CI: 51.1-100.0%) in the Midwest region to 56.7% (95%CI: 37.4-76.0%) in the Northeast region. Main conclusions: vaccination against MDC in Brazil had a positive impact on the population of children aged < 1 year, across all regions, and on the 1-4 year-old cohort. Nevertheless, in our view there is scope for improving the vaccination strategy adopted in Brazil.