Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate

Detalhes bibliográficos
Autor(a) principal: Caramelli, Bruno
Data de Publicação: 2001
Outros Autores: Bernoche, Claudia Y.S.M. de, Sartori, Ana M.C, Spósito, Andrei Carvalho, Santos, Raul D., Monachini, Maristela C., Strabelli, Tania, Uip, Davi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/4026
Resumo: 7 f.
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spelling Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrateColesterolLipídiosHIV - infecçãoTriglicerídios7 f.Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed. In Group II, fenofibrate treatment was associated with decrements of 6.6% (TC) and 45.7% (TG) (p=0.07 and 0.0002) and no modifications on CPK, CD4+, and viral load. In conclusion, hyperlipidemia is common during the treatment of HIV with protease inhibitors, and fenofibrate appears to be an effective and safe choice for its treatment.Faculdade de Medicina (FMD)2010-03-26T13:39:30Z2010-03-26T13:39:30Z2001-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfCARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007&Ing=en&nrm=iso>. Acesso em 15 mar. 2010.http://repositorio.unb.br/handle/10482/4026Caramelli, BrunoBernoche, Claudia Y.S.M. deSartori, Ana M.CSpósito, Andrei CarvalhoSantos, Raul D.Monachini, Maristela C.Strabelli, TaniaUip, Daviinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T03:08:41Zoai:repositorio.unb.br:10482/4026Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T03:08:41Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
spellingShingle Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
Caramelli, Bruno
Colesterol
Lipídios
HIV - infecção
Triglicerídios
title_short Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_full Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_fullStr Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_full_unstemmed Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_sort Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
author Caramelli, Bruno
author_facet Caramelli, Bruno
Bernoche, Claudia Y.S.M. de
Sartori, Ana M.C
Spósito, Andrei Carvalho
Santos, Raul D.
Monachini, Maristela C.
Strabelli, Tania
Uip, Davi
author_role author
author2 Bernoche, Claudia Y.S.M. de
Sartori, Ana M.C
Spósito, Andrei Carvalho
Santos, Raul D.
Monachini, Maristela C.
Strabelli, Tania
Uip, Davi
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caramelli, Bruno
Bernoche, Claudia Y.S.M. de
Sartori, Ana M.C
Spósito, Andrei Carvalho
Santos, Raul D.
Monachini, Maristela C.
Strabelli, Tania
Uip, Davi
dc.subject.por.fl_str_mv Colesterol
Lipídios
HIV - infecção
Triglicerídios
topic Colesterol
Lipídios
HIV - infecção
Triglicerídios
description 7 f.
publishDate 2001
dc.date.none.fl_str_mv 2001-12
2010-03-26T13:39:30Z
2010-03-26T13:39:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv CARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007&Ing=en&nrm=iso>. Acesso em 15 mar. 2010.
http://repositorio.unb.br/handle/10482/4026
identifier_str_mv CARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007&Ing=en&nrm=iso>. Acesso em 15 mar. 2010.
url http://repositorio.unb.br/handle/10482/4026
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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