Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects

Detalhes bibliográficos
Autor(a) principal: Spósito, Andrei Carvalho
Data de Publicação: 2001
Outros Autores: Mansur, A.P., Maranhão, R.C., Rodrigues-Sobrinho, C.R.M., Coelho, O.R., Ramires, José Antonio F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/4024
Resumo: 6 f.
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spelling Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjectsNiacinaLipoproteínaTriglicerídiosColesterol6 f.Etofibrate is a hybrid drug which combines niacin with clofibrate. After contact with plasma hydrolases, both constituents are gradually released in a controlled-release manner. In this study, we compared the effects of etofibrate and controlled-release niacin on lipid profile and plasma lipoprotein (a) (Lp(a)) levels of patients with triglyceride levels of 200 to 400 mg/dl, total cholesterol above 240 mg/dl and Lp(a) above 40 mg/dl. These patients were randomly assigned to a double-blind 16-week treatment period with etofibrate (500 mg twice daily, N = 14) or niacin (500 mg twice daily, N = 11). In both treatment groups total cholesterol, VLDL cholesterol and triglycerides were equally reduced and high-density lipoprotein cholesterol was increased. Etofibrate, but not niacin, reduced Lp(a) by 26% and low-density lipoprotein (LDL) cholesterol by 23%. The hybrid compound etofibrate produced a more effective reduction in plasma LDL cholesterol and Lp(a) levels than controlled-release niacin in type IIb dyslipidemic subjects.Faculdade de Medicina (FMD)2010-03-26T13:31:04Z2010-03-26T13:31:04Z2001info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSPÓSITO, Andrei. Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 2, p. 177-182, fev. 2001. Disponível em: <http://www.scielo.br/scielo.php?pid=S0100-879X2001000200004&script=sci_arttext>. Acesso em: 15 mar. 2010.http://repositorio.unb.br/handle/10482/4024Spósito, Andrei CarvalhoMansur, A.P.Maranhão, R.C.Rodrigues-Sobrinho, C.R.M.Coelho, O.R.Ramires, José Antonio F.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T02:39:11Zoai:repositorio.unb.br:10482/4024Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T02:39:11Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
title Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
spellingShingle Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
Spósito, Andrei Carvalho
Niacina
Lipoproteína
Triglicerídios
Colesterol
title_short Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
title_full Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
title_fullStr Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
title_full_unstemmed Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
title_sort Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects
author Spósito, Andrei Carvalho
author_facet Spósito, Andrei Carvalho
Mansur, A.P.
Maranhão, R.C.
Rodrigues-Sobrinho, C.R.M.
Coelho, O.R.
Ramires, José Antonio F.
author_role author
author2 Mansur, A.P.
Maranhão, R.C.
Rodrigues-Sobrinho, C.R.M.
Coelho, O.R.
Ramires, José Antonio F.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Spósito, Andrei Carvalho
Mansur, A.P.
Maranhão, R.C.
Rodrigues-Sobrinho, C.R.M.
Coelho, O.R.
Ramires, José Antonio F.
dc.subject.por.fl_str_mv Niacina
Lipoproteína
Triglicerídios
Colesterol
topic Niacina
Lipoproteína
Triglicerídios
Colesterol
description 6 f.
publishDate 2001
dc.date.none.fl_str_mv 2001
2010-03-26T13:31:04Z
2010-03-26T13:31:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv SPÓSITO, Andrei. Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 2, p. 177-182, fev. 2001. Disponível em: <http://www.scielo.br/scielo.php?pid=S0100-879X2001000200004&script=sci_arttext>. Acesso em: 15 mar. 2010.
http://repositorio.unb.br/handle/10482/4024
identifier_str_mv SPÓSITO, Andrei. Etofibrate but not controlled-release niacin decreases LDL cholesterol and lipoprotein (a) in type IIb dyslipidemic subjects. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 2, p. 177-182, fev. 2001. Disponível em: <http://www.scielo.br/scielo.php?pid=S0100-879X2001000200004&script=sci_arttext>. Acesso em: 15 mar. 2010.
url http://repositorio.unb.br/handle/10482/4024
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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