L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/26374 https://dx.doi.org/10.1590/S0100-879X2005000100001 |
Resumo: | The present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia. |
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L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasiaHuman Papillomavirushpv-58l1 GenesVariantesThe present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia.Em processamentoAssociação Brasileira de Divulgação Científica2017-12-07T04:42:13Z2017-12-07T04:42:13Z2005info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBraz J Med Biol Res,v.38,n.1,p.1-4,2005http://repositorio.unb.br/handle/10482/26374https://dx.doi.org/10.1590/S0100-879X2005000100001Veras, V.S.Cerqueira, D.M.Martins, C.R.F.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-08-28T19:04:09Zoai:repositorio.unb.br:10482/26374Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-08-28T19:04:09Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
spellingShingle |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia Veras, V.S. Human Papillomavirus hpv-58 l1 Genes Variantes |
title_short |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_full |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_fullStr |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_full_unstemmed |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_sort |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
author |
Veras, V.S. |
author_facet |
Veras, V.S. Cerqueira, D.M. Martins, C.R.F. |
author_role |
author |
author2 |
Cerqueira, D.M. Martins, C.R.F. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Veras, V.S. Cerqueira, D.M. Martins, C.R.F. |
dc.subject.por.fl_str_mv |
Human Papillomavirus hpv-58 l1 Genes Variantes |
topic |
Human Papillomavirus hpv-58 l1 Genes Variantes |
description |
The present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005 2017-12-07T04:42:13Z 2017-12-07T04:42:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Braz J Med Biol Res,v.38,n.1,p.1-4,2005 http://repositorio.unb.br/handle/10482/26374 https://dx.doi.org/10.1590/S0100-879X2005000100001 |
identifier_str_mv |
Braz J Med Biol Res,v.38,n.1,p.1-4,2005 |
url |
http://repositorio.unb.br/handle/10482/26374 https://dx.doi.org/10.1590/S0100-879X2005000100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
instacron_str |
UNB |
institution |
UNB |
reponame_str |
Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
repository.name.fl_str_mv |
Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
repositorio@unb.br |
_version_ |
1814508254050385920 |