L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia

Detalhes bibliográficos
Autor(a) principal: Veras, V.S.
Data de Publicação: 2005
Outros Autores: Cerqueira, D.M., Martins, C.R.F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/26374
https://dx.doi.org/10.1590/S0100-879X2005000100001
Resumo: The present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia.
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spelling L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasiaHuman Papillomavirushpv-58l1 GenesVariantesThe present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia.Em processamentoAssociação Brasileira de Divulgação Científica2017-12-07T04:42:13Z2017-12-07T04:42:13Z2005info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBraz J Med Biol Res,v.38,n.1,p.1-4,2005http://repositorio.unb.br/handle/10482/26374https://dx.doi.org/10.1590/S0100-879X2005000100001Veras, V.S.Cerqueira, D.M.Martins, C.R.F.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-08-28T19:04:09Zoai:repositorio.unb.br:10482/26374Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-08-28T19:04:09Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
title L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
spellingShingle L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
Veras, V.S.
Human Papillomavirus
hpv-58
l1 Genes
Variantes
title_short L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
title_full L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
title_fullStr L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
title_full_unstemmed L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
title_sort L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
author Veras, V.S.
author_facet Veras, V.S.
Cerqueira, D.M.
Martins, C.R.F.
author_role author
author2 Cerqueira, D.M.
Martins, C.R.F.
author2_role author
author
dc.contributor.author.fl_str_mv Veras, V.S.
Cerqueira, D.M.
Martins, C.R.F.
dc.subject.por.fl_str_mv Human Papillomavirus
hpv-58
l1 Genes
Variantes
topic Human Papillomavirus
hpv-58
l1 Genes
Variantes
description The present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia.
publishDate 2005
dc.date.none.fl_str_mv 2005
2017-12-07T04:42:13Z
2017-12-07T04:42:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Braz J Med Biol Res,v.38,n.1,p.1-4,2005
http://repositorio.unb.br/handle/10482/26374
https://dx.doi.org/10.1590/S0100-879X2005000100001
identifier_str_mv Braz J Med Biol Res,v.38,n.1,p.1-4,2005
url http://repositorio.unb.br/handle/10482/26374
https://dx.doi.org/10.1590/S0100-879X2005000100001
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
instacron:UNB
instname_str Universidade de Brasília (UnB)
instacron_str UNB
institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
repository.mail.fl_str_mv repositorio@unb.br
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