Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil

• Autor(a) principal: Cruz, Márcio R
• Data de Publicação: 2004
• Outros Autores: Cerqueira, Daniela M, Cruz, Waldenor B, Camara, Geni NL, Brígido, Marcelo de Macedo, Silva, Evandro O, Carvalho, Luciano GS, Martins, Cláudia RF
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UnB
• Texto Completo: http://repositorio.unb.br/handle/10482/26144; https://dx.doi.org/10.1590/S0074-02762004000300007
• topic: human papillomavirus type 16; variants; Federal District; Brazil

We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions - atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.