Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/30655 http://dx.doi.org/10.1016/j.bjp.2017.01.006 |
Resumo: | Ayahuasca is a psychoactive beverage used ancestrally by indigenous Amazonian tribes and, more recently, by Christian religions in Brazil and other countries. This study aimed to investigate the reproductive effects of this beverage in male Wistar rats after chronic exposure. The rats were treated by gavage every other day for 70 days at 0 (control), 1×, 2×, 4× and 8× the dose used in a religious ritual (12 animals per group), and animals euthanized on the 71st day. Compared to controls, there was a significant decrease in food consumption and body weight gain in rats from the 4× and 8× groups, and a significant increase in the brain and stomach relative weight at the 8× group. There was a significant increase in total serum testosterone, and a decrease in spermatic transit time and spermatic reserves in the epididymis caudae in the 4× group, but not in the highest dose group. No significant changes were found in the other reproductive endpoints (spermatozoid motility and morphology, total spermatozoid count and daily sperm production), and histology of testis and epididymis. This study identified a no-observed-adverse-effect-level for chronic and reproductive effects of ayahuasca in male Wistar rats at 2× the ritualistic dose, which corresponds in this study to 0.62 mg/kg bw N, N-dimethyltryptamine, 6.6 mg/kg bw harmine and 0.52 mg/kg bw harmaline. A potential toxic effect of ayahuasca in male rats was observed at the 4× dose, with a non-monotonic dose–response. Studies investigating the role of ayahuasca components in regulating testosterone levels are needed to better understand this action. |
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Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposureToxicidadeRatosTestosteronaAyahuasca is a psychoactive beverage used ancestrally by indigenous Amazonian tribes and, more recently, by Christian religions in Brazil and other countries. This study aimed to investigate the reproductive effects of this beverage in male Wistar rats after chronic exposure. The rats were treated by gavage every other day for 70 days at 0 (control), 1×, 2×, 4× and 8× the dose used in a religious ritual (12 animals per group), and animals euthanized on the 71st day. Compared to controls, there was a significant decrease in food consumption and body weight gain in rats from the 4× and 8× groups, and a significant increase in the brain and stomach relative weight at the 8× group. There was a significant increase in total serum testosterone, and a decrease in spermatic transit time and spermatic reserves in the epididymis caudae in the 4× group, but not in the highest dose group. No significant changes were found in the other reproductive endpoints (spermatozoid motility and morphology, total spermatozoid count and daily sperm production), and histology of testis and epididymis. This study identified a no-observed-adverse-effect-level for chronic and reproductive effects of ayahuasca in male Wistar rats at 2× the ritualistic dose, which corresponds in this study to 0.62 mg/kg bw N, N-dimethyltryptamine, 6.6 mg/kg bw harmine and 0.52 mg/kg bw harmaline. A potential toxic effect of ayahuasca in male rats was observed at the 4× dose, with a non-monotonic dose–response. Studies investigating the role of ayahuasca components in regulating testosterone levels are needed to better understand this action.Sociedade Brasileira de Farmacognosia2018-01-04T19:14:18Z2018-01-04T19:14:18Z2017-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSANTOS, Alana de Fátima Andrade et al. Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure. Revista Brasileira de Farmacognosia, Curitiba, v. 27, n. 3, p. 353-360, maio/jun. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000300353&lng=en&nrm=iso>. Acesso em: 15 fev. 2018. doi: http://dx.doi.org/10.1016/j.bjp.2017.01.006.http://repositorio.unb.br/handle/10482/30655http://dx.doi.org/10.1016/j.bjp.2017.01.006Revista Brasileira de Farmacognosia - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way (CC BY NC ND 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000300353&lng=en&nrm=iso. Acesso em: 15 fev. 2018.info:eu-repo/semantics/openAccessSantos, Alana de Fátima AndradeVieira, Ana Luiza SarkisPic-Taylor, AlineCaldas, Eloisa Dutraengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2024-09-09T13:11:38Zoai:repositorio.unb.br:10482/30655Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2024-09-09T13:11:38Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure |
title |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure |
spellingShingle |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure Santos, Alana de Fátima Andrade Toxicidade Ratos Testosterona |
title_short |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure |
title_full |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure |
title_fullStr |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure |
title_full_unstemmed |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure |
title_sort |
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure |
author |
Santos, Alana de Fátima Andrade |
author_facet |
Santos, Alana de Fátima Andrade Vieira, Ana Luiza Sarkis Pic-Taylor, Aline Caldas, Eloisa Dutra |
author_role |
author |
author2 |
Vieira, Ana Luiza Sarkis Pic-Taylor, Aline Caldas, Eloisa Dutra |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Santos, Alana de Fátima Andrade Vieira, Ana Luiza Sarkis Pic-Taylor, Aline Caldas, Eloisa Dutra |
dc.subject.por.fl_str_mv |
Toxicidade Ratos Testosterona |
topic |
Toxicidade Ratos Testosterona |
description |
Ayahuasca is a psychoactive beverage used ancestrally by indigenous Amazonian tribes and, more recently, by Christian religions in Brazil and other countries. This study aimed to investigate the reproductive effects of this beverage in male Wistar rats after chronic exposure. The rats were treated by gavage every other day for 70 days at 0 (control), 1×, 2×, 4× and 8× the dose used in a religious ritual (12 animals per group), and animals euthanized on the 71st day. Compared to controls, there was a significant decrease in food consumption and body weight gain in rats from the 4× and 8× groups, and a significant increase in the brain and stomach relative weight at the 8× group. There was a significant increase in total serum testosterone, and a decrease in spermatic transit time and spermatic reserves in the epididymis caudae in the 4× group, but not in the highest dose group. No significant changes were found in the other reproductive endpoints (spermatozoid motility and morphology, total spermatozoid count and daily sperm production), and histology of testis and epididymis. This study identified a no-observed-adverse-effect-level for chronic and reproductive effects of ayahuasca in male Wistar rats at 2× the ritualistic dose, which corresponds in this study to 0.62 mg/kg bw N, N-dimethyltryptamine, 6.6 mg/kg bw harmine and 0.52 mg/kg bw harmaline. A potential toxic effect of ayahuasca in male rats was observed at the 4× dose, with a non-monotonic dose–response. Studies investigating the role of ayahuasca components in regulating testosterone levels are needed to better understand this action. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06 2018-01-04T19:14:18Z 2018-01-04T19:14:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
SANTOS, Alana de Fátima Andrade et al. Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure. Revista Brasileira de Farmacognosia, Curitiba, v. 27, n. 3, p. 353-360, maio/jun. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000300353&lng=en&nrm=iso>. Acesso em: 15 fev. 2018. doi: http://dx.doi.org/10.1016/j.bjp.2017.01.006. http://repositorio.unb.br/handle/10482/30655 http://dx.doi.org/10.1016/j.bjp.2017.01.006 |
identifier_str_mv |
SANTOS, Alana de Fátima Andrade et al. Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure. Revista Brasileira de Farmacognosia, Curitiba, v. 27, n. 3, p. 353-360, maio/jun. 2017. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2017000300353&lng=en&nrm=iso>. Acesso em: 15 fev. 2018. doi: http://dx.doi.org/10.1016/j.bjp.2017.01.006. |
url |
http://repositorio.unb.br/handle/10482/30655 http://dx.doi.org/10.1016/j.bjp.2017.01.006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
instacron_str |
UNB |
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UNB |
reponame_str |
Repositório Institucional da UnB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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repositorio@unb.br |
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