Glicoalcaloides antifúngicos, flavonoides e outros constituintes químicos de Solanum asperum

• Autor(a) principal: Pinto, Francisco das Chagas L.
• Data de Publicação: 2011
• Outros Autores: Uchoa, Daniel Esdras de Andrade, Silveira, Edilberto Rocha, Pessoa, Otília Deusdênia Loiola, Braz-Filho, Raimundo, Silva, Fernanda Melo e, Theodoro, Phellipe Norato Estrela Terra, Espindola, Laila Salmen
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UnB
• Texto Completo: http://repositorio.unb.br/handle/10482/13310; http://dx.doi.org/10.1590/S0100-40422011000200021
• topic: Solanum asperum; Antimicóticos; Plantas - compostos bioativos

Two glycoalkaloids: solamargine and solasonine; three flavonoids: tiliroside, 7-O-α-L-ramnopyranosyl-kaempferol and 3-O-[ß-D-glucopyranosyl-(1→6)-α-L-ramnopyranosyl]-7- O-α-L-ramnopyranosyl-kaempferol, in addition to the tripeptide Leu-Ile-Val, the aminoacid proline and the eicosanoic acid were isolated from Solanum asperum (Solanaceae). The structures of all compounds were determined by interpretation of their spectra (IR, MS, 1H and 13C NMR) and comparison with the literature data. All compounds, except the glycoalkaloids, are being reported for the first time for S. asperum. Solasonine showed strong activity (MIC < 0.24 μg/mL) against four filamentous fungi species of the genera Microsporum and Trichophyton.