Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/30496 http://dx.doi.org/10.1590/2359-3997000000174 |
Resumo: | Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers. |
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Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in BrazilCushing, Doença de - diagnósticoSíndrome de CushingAlthough it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers.Faculdade de Medicina (FMD)Sociedade Brasileira de Endocrinologia e Metabologia2017-12-07T05:19:37Z2017-12-07T05:19:37Z2016-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMACHADO, Márcio Carlos et al. Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 3, p. 267-286, jun. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso>. Acesso em: 11 dez. 2017. doi: http://dx.doi.org/10.1590/2359-3997000000174.http://repositorio.unb.br/handle/10482/30496http://dx.doi.org/10.1590/2359-3997000000174Archives of Endocrinology and Metabolism - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso. Acesso em: 11 dez. 2017.info:eu-repo/semantics/openAccessMachado, Márcio CarlosFragoso, Maria Candida Barisson VilaresMoreira, Ayrton CustódioBoguszewski, César LuizVieira Neto, LeonardoNaves, Luciana AnsaneliVilar, LucioAraújo, Luiz Antônio deCzepielewski, Mauro AntonioGadelha, Monica R.Musolino, Nina Rosa CastroMiranda, Paulo Augusto CarvalhoBronstein, Marcello DelanoOliveira Júnior, Antônio Ribeiroengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T19:26:15Zoai:repositorio.unb.br:10482/30496Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T19:26:15Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.none.fl_str_mv |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil |
title |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil |
spellingShingle |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil Machado, Márcio Carlos Cushing, Doença de - diagnóstico Síndrome de Cushing |
title_short |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil |
title_full |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil |
title_fullStr |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil |
title_full_unstemmed |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil |
title_sort |
Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil |
author |
Machado, Márcio Carlos |
author_facet |
Machado, Márcio Carlos Fragoso, Maria Candida Barisson Vilares Moreira, Ayrton Custódio Boguszewski, César Luiz Vieira Neto, Leonardo Naves, Luciana Ansaneli Vilar, Lucio Araújo, Luiz Antônio de Czepielewski, Mauro Antonio Gadelha, Monica R. Musolino, Nina Rosa Castro Miranda, Paulo Augusto Carvalho Bronstein, Marcello Delano Oliveira Júnior, Antônio Ribeiro |
author_role |
author |
author2 |
Fragoso, Maria Candida Barisson Vilares Moreira, Ayrton Custódio Boguszewski, César Luiz Vieira Neto, Leonardo Naves, Luciana Ansaneli Vilar, Lucio Araújo, Luiz Antônio de Czepielewski, Mauro Antonio Gadelha, Monica R. Musolino, Nina Rosa Castro Miranda, Paulo Augusto Carvalho Bronstein, Marcello Delano Oliveira Júnior, Antônio Ribeiro |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Márcio Carlos Fragoso, Maria Candida Barisson Vilares Moreira, Ayrton Custódio Boguszewski, César Luiz Vieira Neto, Leonardo Naves, Luciana Ansaneli Vilar, Lucio Araújo, Luiz Antônio de Czepielewski, Mauro Antonio Gadelha, Monica R. Musolino, Nina Rosa Castro Miranda, Paulo Augusto Carvalho Bronstein, Marcello Delano Oliveira Júnior, Antônio Ribeiro |
dc.subject.por.fl_str_mv |
Cushing, Doença de - diagnóstico Síndrome de Cushing |
topic |
Cushing, Doença de - diagnóstico Síndrome de Cushing |
description |
Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06 2017-12-07T05:19:37Z 2017-12-07T05:19:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MACHADO, Márcio Carlos et al. Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 3, p. 267-286, jun. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso>. Acesso em: 11 dez. 2017. doi: http://dx.doi.org/10.1590/2359-3997000000174. http://repositorio.unb.br/handle/10482/30496 http://dx.doi.org/10.1590/2359-3997000000174 |
identifier_str_mv |
MACHADO, Márcio Carlos et al. Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 3, p. 267-286, jun. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso>. Acesso em: 11 dez. 2017. doi: http://dx.doi.org/10.1590/2359-3997000000174. |
url |
http://repositorio.unb.br/handle/10482/30496 http://dx.doi.org/10.1590/2359-3997000000174 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
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Universidade de Brasília (UnB) |
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UNB |
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UNB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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repositorio@unb.br |
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