Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil

Detalhes bibliográficos
Autor(a) principal: Machado, Márcio Carlos
Data de Publicação: 2016
Outros Autores: Fragoso, Maria Candida Barisson Vilares, Moreira, Ayrton Custódio, Boguszewski, César Luiz, Vieira Neto, Leonardo, Naves, Luciana Ansaneli, Vilar, Lucio, Araújo, Luiz Antônio de, Czepielewski, Mauro Antonio, Gadelha, Monica R., Musolino, Nina Rosa Castro, Miranda, Paulo Augusto Carvalho, Bronstein, Marcello Delano, Oliveira Júnior, Antônio Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/30496
http://dx.doi.org/10.1590/2359-3997000000174
Resumo: Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers.
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spelling Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in BrazilCushing, Doença de - diagnósticoSíndrome de CushingAlthough it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers.Faculdade de Medicina (FMD)Sociedade Brasileira de Endocrinologia e Metabologia2017-12-07T05:19:37Z2017-12-07T05:19:37Z2016-06info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMACHADO, Márcio Carlos et al. Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 3, p. 267-286, jun. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso>. Acesso em: 11 dez. 2017. doi: http://dx.doi.org/10.1590/2359-3997000000174.http://repositorio.unb.br/handle/10482/30496http://dx.doi.org/10.1590/2359-3997000000174Archives of Endocrinology and Metabolism - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso. Acesso em: 11 dez. 2017.info:eu-repo/semantics/openAccessMachado, Márcio CarlosFragoso, Maria Candida Barisson VilaresMoreira, Ayrton CustódioBoguszewski, César LuizVieira Neto, LeonardoNaves, Luciana AnsaneliVilar, LucioAraújo, Luiz Antônio deCzepielewski, Mauro AntonioGadelha, Monica R.Musolino, Nina Rosa CastroMiranda, Paulo Augusto CarvalhoBronstein, Marcello DelanoOliveira Júnior, Antônio Ribeiroengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNB2023-08-25T19:26:15Zoai:repositorio.unb.br:10482/30496Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-08-25T19:26:15Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.none.fl_str_mv Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
title Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
spellingShingle Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
Machado, Márcio Carlos
Cushing, Doença de - diagnóstico
Síndrome de Cushing
title_short Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
title_full Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
title_fullStr Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
title_full_unstemmed Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
title_sort Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil
author Machado, Márcio Carlos
author_facet Machado, Márcio Carlos
Fragoso, Maria Candida Barisson Vilares
Moreira, Ayrton Custódio
Boguszewski, César Luiz
Vieira Neto, Leonardo
Naves, Luciana Ansaneli
Vilar, Lucio
Araújo, Luiz Antônio de
Czepielewski, Mauro Antonio
Gadelha, Monica R.
Musolino, Nina Rosa Castro
Miranda, Paulo Augusto Carvalho
Bronstein, Marcello Delano
Oliveira Júnior, Antônio Ribeiro
author_role author
author2 Fragoso, Maria Candida Barisson Vilares
Moreira, Ayrton Custódio
Boguszewski, César Luiz
Vieira Neto, Leonardo
Naves, Luciana Ansaneli
Vilar, Lucio
Araújo, Luiz Antônio de
Czepielewski, Mauro Antonio
Gadelha, Monica R.
Musolino, Nina Rosa Castro
Miranda, Paulo Augusto Carvalho
Bronstein, Marcello Delano
Oliveira Júnior, Antônio Ribeiro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Márcio Carlos
Fragoso, Maria Candida Barisson Vilares
Moreira, Ayrton Custódio
Boguszewski, César Luiz
Vieira Neto, Leonardo
Naves, Luciana Ansaneli
Vilar, Lucio
Araújo, Luiz Antônio de
Czepielewski, Mauro Antonio
Gadelha, Monica R.
Musolino, Nina Rosa Castro
Miranda, Paulo Augusto Carvalho
Bronstein, Marcello Delano
Oliveira Júnior, Antônio Ribeiro
dc.subject.por.fl_str_mv Cushing, Doença de - diagnóstico
Síndrome de Cushing
topic Cushing, Doença de - diagnóstico
Síndrome de Cushing
description Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers.
publishDate 2016
dc.date.none.fl_str_mv 2016-06
2017-12-07T05:19:37Z
2017-12-07T05:19:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv MACHADO, Márcio Carlos et al. Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 3, p. 267-286, jun. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso>. Acesso em: 11 dez. 2017. doi: http://dx.doi.org/10.1590/2359-3997000000174.
http://repositorio.unb.br/handle/10482/30496
http://dx.doi.org/10.1590/2359-3997000000174
identifier_str_mv MACHADO, Márcio Carlos et al. Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 3, p. 267-286, jun. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso>. Acesso em: 11 dez. 2017. doi: http://dx.doi.org/10.1590/2359-3997000000174.
url http://repositorio.unb.br/handle/10482/30496
http://dx.doi.org/10.1590/2359-3997000000174
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UnB
instname:Universidade de Brasília (UnB)
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institution UNB
reponame_str Repositório Institucional da UnB
collection Repositório Institucional da UnB
repository.name.fl_str_mv Repositório Institucional da UnB - Universidade de Brasília (UnB)
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