Applied technologies to prolong drug release: an integrative review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | |
| Tipo de documento: | Artigo |
| Idioma: | por eng |
| Título da fonte: | Diversitas Journal |
| Texto Completo: | https://diversitasjournal.com.br/diversitas_journal/article/view/2429 |
Resumo: | Extended-release systems have several advantages, such as greater availability of the drug in the bloodstream and fewer side effects, being properly applied to drugs that have a short biological half-life, requiring a "medium" for the drug to remain for a period of time. extended, reaching its destination. The objective of this study was to show three technologies currently used in order to prolong the release/action of the drug. An integrative review was carried out, collecting articles from the following databases: VHL, Google academic, Scielo and Pubmed, published in the last 10 years. Thus, the importance of these systems and their applicability was demonstrated, including the benefits for the patient, when using a drug with an extended effect, since it is usually necessary to ingest several doses, so that the therapeutic effect is obtained. It is concluded that the implementation of these systems has satisfactory performance against drugs that do not use these technologies, favoring the patient with a better therapeutic effect, due to easier adherence. |
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Applied technologies to prolong drug release: an integrative reviewTecnologias aplicadas para prolongar a liberação de fármacos: uma revisão integrativaSistema de entrega de drogasEntrega de medicamentosSistemas de matriz de medicamentosDrogas de bombas osmóticasSistema de reservatório de drogasSystem drugs delivery; Delivery of drugs; Drug matrix systems; Osmotic pump drugs; Drug reservoir systemExtended-release systems have several advantages, such as greater availability of the drug in the bloodstream and fewer side effects, being properly applied to drugs that have a short biological half-life, requiring a "medium" for the drug to remain for a period of time. extended, reaching its destination. The objective of this study was to show three technologies currently used in order to prolong the release/action of the drug. An integrative review was carried out, collecting articles from the following databases: VHL, Google academic, Scielo and Pubmed, published in the last 10 years. Thus, the importance of these systems and their applicability was demonstrated, including the benefits for the patient, when using a drug with an extended effect, since it is usually necessary to ingest several doses, so that the therapeutic effect is obtained. It is concluded that the implementation of these systems has satisfactory performance against drugs that do not use these technologies, favoring the patient with a better therapeutic effect, due to easier adherence.Os sistemas de liberação prolongada possuem diversas vantagens, como maior disponibilidade do fármaco na corrente sanguínea e menos efeitos colaterais, aplicando-se adequadamente a fármacos que possuem meia-vida biológica curta, sendo necessário um “meio” para que o fármaco permaneça por um período estendido, atingindo seu destino. O objetivo deste estudo foi mostrar três tecnologias utilizadas atualmente, a fim de prolongar a liberação/ação do fármaco. Foi realizada uma revisão integrativa, colhendo artigos das bases de dados: BVS, Google acadêmico, Scielo e Pubmed, publicado nos últimos 10 anos. Assim, foi demonstrada a importância desses sistemas e suas aplicabilidades, compreendendo os benefícios para o paciente, ao usar um medicamento com efeito estendido, já que usualmente, muitas vezes se faz necessário ingerir várias doses, para que o efeito terapêutico seja obtido. Conclui-se que a implementação desses sistemas possui desempenho satisfatório frente a medicamentos que não utilizam essas tecnologias, favorecendo ao paciente um efeito terapêutico melhor, devido a uma adesão mais facilitada.Universidade Estadual de Alagoas - Eduneal2023-04-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://diversitasjournal.com.br/diversitas_journal/article/view/242910.48017/dj.v8i2.2429Diversitas Journal; Vol. 8 No. 2 (2023): Através das lentes: a importância da biodiversidade para o equilíbrio ambiental; 874–885Diversitas Journal; Vol. 8 Núm. 2 (2023): Através das lentes: a importância da biodiversidade para o equilíbrio ambiental; 874–885Diversitas Journal; v. 8 n. 2 (2023): Através das lentes: a importância da biodiversidade para o equilíbrio ambiental; 874–8852525-521510.48017/dj.v8i2reponame:Diversitas Journalinstname:Universidade Estadual de Alagoas (UNEAL)instacron:UNEALporenghttps://diversitasjournal.com.br/diversitas_journal/article/view/2429/2053https://diversitasjournal.com.br/diversitas_journal/article/view/2429/2104Copyright (c) 2023 Ana Melo, Danilo Fonteshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMelo, Ana Vithória da SilvaFontes, Danilo Augusto Ferreira2023-11-09T22:04:16Zoai:ojs.diversitasjournal.com.br:article/2429Revistahttps://diversitasjournal.com.br/diversitas_journal/indexPUBhttps://www.e-publicacoes.uerj.br/index.php/muralinternacional/oairevistadiversitasjournal@gmail.com2525-52152525-5215opendoar:2023-11-09T22:04:16Diversitas Journal - Universidade Estadual de Alagoas (UNEAL)false |
| dc.title.none.fl_str_mv |
Applied technologies to prolong drug release: an integrative review Tecnologias aplicadas para prolongar a liberação de fármacos: uma revisão integrativa |
| title |
Applied technologies to prolong drug release: an integrative review |
| spellingShingle |
Applied technologies to prolong drug release: an integrative review Melo, Ana Vithória da Silva Sistema de entrega de drogas Entrega de medicamentos Sistemas de matriz de medicamentos Drogas de bombas osmóticas Sistema de reservatório de drogas System drugs delivery; Delivery of drugs; Drug matrix systems; Osmotic pump drugs; Drug reservoir system |
| title_short |
Applied technologies to prolong drug release: an integrative review |
| title_full |
Applied technologies to prolong drug release: an integrative review |
| title_fullStr |
Applied technologies to prolong drug release: an integrative review |
| title_full_unstemmed |
Applied technologies to prolong drug release: an integrative review |
| title_sort |
Applied technologies to prolong drug release: an integrative review |
| author |
Melo, Ana Vithória da Silva |
| author_facet |
Melo, Ana Vithória da Silva Fontes, Danilo Augusto Ferreira |
| author_role |
author |
| author2 |
Fontes, Danilo Augusto Ferreira |
| author2_role |
author |
| dc.contributor.author.fl_str_mv |
Melo, Ana Vithória da Silva Fontes, Danilo Augusto Ferreira |
| dc.subject.por.fl_str_mv |
Sistema de entrega de drogas Entrega de medicamentos Sistemas de matriz de medicamentos Drogas de bombas osmóticas Sistema de reservatório de drogas System drugs delivery; Delivery of drugs; Drug matrix systems; Osmotic pump drugs; Drug reservoir system |
| topic |
Sistema de entrega de drogas Entrega de medicamentos Sistemas de matriz de medicamentos Drogas de bombas osmóticas Sistema de reservatório de drogas System drugs delivery; Delivery of drugs; Drug matrix systems; Osmotic pump drugs; Drug reservoir system |
| description |
Extended-release systems have several advantages, such as greater availability of the drug in the bloodstream and fewer side effects, being properly applied to drugs that have a short biological half-life, requiring a "medium" for the drug to remain for a period of time. extended, reaching its destination. The objective of this study was to show three technologies currently used in order to prolong the release/action of the drug. An integrative review was carried out, collecting articles from the following databases: VHL, Google academic, Scielo and Pubmed, published in the last 10 years. Thus, the importance of these systems and their applicability was demonstrated, including the benefits for the patient, when using a drug with an extended effect, since it is usually necessary to ingest several doses, so that the therapeutic effect is obtained. It is concluded that the implementation of these systems has satisfactory performance against drugs that do not use these technologies, favoring the patient with a better therapeutic effect, due to easier adherence. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-04-10 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://diversitasjournal.com.br/diversitas_journal/article/view/2429 10.48017/dj.v8i2.2429 |
| url |
https://diversitasjournal.com.br/diversitas_journal/article/view/2429 |
| identifier_str_mv |
10.48017/dj.v8i2.2429 |
| dc.language.iso.fl_str_mv |
por eng |
| language |
por eng |
| dc.relation.none.fl_str_mv |
https://diversitasjournal.com.br/diversitas_journal/article/view/2429/2053 https://diversitasjournal.com.br/diversitas_journal/article/view/2429/2104 |
| dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Ana Melo, Danilo Fontes https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Copyright (c) 2023 Ana Melo, Danilo Fontes https://creativecommons.org/licenses/by/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Universidade Estadual de Alagoas - Eduneal |
| publisher.none.fl_str_mv |
Universidade Estadual de Alagoas - Eduneal |
| dc.source.none.fl_str_mv |
Diversitas Journal; Vol. 8 No. 2 (2023): Através das lentes: a importância da biodiversidade para o equilíbrio ambiental; 874–885 Diversitas Journal; Vol. 8 Núm. 2 (2023): Através das lentes: a importância da biodiversidade para o equilíbrio ambiental; 874–885 Diversitas Journal; v. 8 n. 2 (2023): Através das lentes: a importância da biodiversidade para o equilíbrio ambiental; 874–885 2525-5215 10.48017/dj.v8i2 reponame:Diversitas Journal instname:Universidade Estadual de Alagoas (UNEAL) instacron:UNEAL |
| instname_str |
Universidade Estadual de Alagoas (UNEAL) |
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UNEAL |
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UNEAL |
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Diversitas Journal |
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Diversitas Journal |
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Diversitas Journal - Universidade Estadual de Alagoas (UNEAL) |
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revistadiversitasjournal@gmail.com |
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1797051272737587200 |