Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities

Detalhes bibliográficos
Autor(a) principal: Wu,Ting
Data de Publicação: 2019
Outros Autores: Wang,Meng, Wu,Wenfang, Luo,Qianxuan, Jiang,Liping, Tao,Huai, Deng,Meichun
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100203
Resumo: Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain.
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spelling Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activitiesspider venom peptidesantitumorpaindrug candidatesAbstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100203Journal of Venomous Animals and Toxins including Tropical Diseases v.25 2019reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/1678-9199-jvatitd-14-63-18info:eu-repo/semantics/openAccessWu,TingWang,MengWu,WenfangLuo,QianxuanJiang,LipingTao,HuaiDeng,Meichuneng2019-07-04T00:00:00Zoai:scielo:S1678-91992019000100203Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2019-07-04T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
title Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
spellingShingle Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Wu,Ting
spider venom peptides
antitumor
pain
drug candidates
title_short Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
title_full Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
title_fullStr Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
title_full_unstemmed Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
title_sort Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
author Wu,Ting
author_facet Wu,Ting
Wang,Meng
Wu,Wenfang
Luo,Qianxuan
Jiang,Liping
Tao,Huai
Deng,Meichun
author_role author
author2 Wang,Meng
Wu,Wenfang
Luo,Qianxuan
Jiang,Liping
Tao,Huai
Deng,Meichun
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Wu,Ting
Wang,Meng
Wu,Wenfang
Luo,Qianxuan
Jiang,Liping
Tao,Huai
Deng,Meichun
dc.subject.por.fl_str_mv spider venom peptides
antitumor
pain
drug candidates
topic spider venom peptides
antitumor
pain
drug candidates
description Abstract Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100203
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100203
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1678-9199-jvatitd-14-63-18
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.25 2019
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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