Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus

Detalhes bibliográficos
Autor(a) principal: Silva,Ara
Data de Publicação: 2011
Outros Autores: Morais,SM, Marques,MMM, Lima,DM, Santos,SCC, Almeida,RR, Vieira,IGP, Guedes,MIF
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007
Resumo: In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL, respectively.
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spelling Antiviral activities of extracts and phenolic components of two Spondias species against dengue virusnatural productsphenolsdengueantiviral agentsIn recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL, respectively.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007Journal of Venomous Animals and Toxins including Tropical Diseases v.17 n.4 2011reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992011000400007info:eu-repo/semantics/openAccessSilva,AraMorais,SMMarques,MMMLima,DMSantos,SCCAlmeida,RRVieira,IGPGuedes,MIFeng2011-12-05T00:00:00Zoai:scielo:S1678-91992011000400007Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2011-12-05T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
title Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
spellingShingle Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
Silva,Ara
natural products
phenols
dengue
antiviral agents
title_short Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
title_full Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
title_fullStr Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
title_full_unstemmed Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
title_sort Antiviral activities of extracts and phenolic components of two Spondias species against dengue virus
author Silva,Ara
author_facet Silva,Ara
Morais,SM
Marques,MMM
Lima,DM
Santos,SCC
Almeida,RR
Vieira,IGP
Guedes,MIF
author_role author
author2 Morais,SM
Marques,MMM
Lima,DM
Santos,SCC
Almeida,RR
Vieira,IGP
Guedes,MIF
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Ara
Morais,SM
Marques,MMM
Lima,DM
Santos,SCC
Almeida,RR
Vieira,IGP
Guedes,MIF
dc.subject.por.fl_str_mv natural products
phenols
dengue
antiviral agents
topic natural products
phenols
dengue
antiviral agents
description In recent years, the search for natural plant products to fight viral diseases has been increasing. In this work, two Spondias species, namely S. mombin and S. tuberosa, found in Ceará state (Brazil), and their main phenolic components were evaluated against dengue virus. In vitro antiviral tests were performed against type-2 dengue virus by the MTT method and standard cytopathic effect reduction assay in C6/36 cells. Cytotoxicity was also evaluated by MTT. The presence of phenolic compounds quercetin, rutin, and ellagic acid in plant extracts was characterized by HPLC analysis. Both Spondias species extracts and components were nontoxic to the cells whereas rutin and quercetin displayed relevant antiviral activity with IC50 of 362.68 µg/mL and 500 µg/mL, respectively.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992011000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.17 n.4 2011
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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