Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy

Detalhes bibliográficos
Autor(a) principal: Chippaux,Jean-Philippe
Data de Publicação: 2015
Outros Autores: Boyer,Leslie V, Alagón,Alejandro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100203
Resumo: Background Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Conclusion Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.
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spelling Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategyEbolaEpidemicsImmunotherapyProphylaxisAfrica Background Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Conclusion Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus. Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2015-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100203Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-015-0003-1info:eu-repo/semantics/openAccessChippaux,Jean-PhilippeBoyer,Leslie VAlagón,Alejandroeng2015-08-04T00:00:00Zoai:scielo:S1678-91992015000100203Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2015-08-04T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
title Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
spellingShingle Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
Chippaux,Jean-Philippe
Ebola
Epidemics
Immunotherapy
Prophylaxis
Africa
title_short Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
title_full Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
title_fullStr Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
title_full_unstemmed Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
title_sort Post-exposure treatment of Ebola virus using passive immunotherapy: proposal for a new strategy
author Chippaux,Jean-Philippe
author_facet Chippaux,Jean-Philippe
Boyer,Leslie V
Alagón,Alejandro
author_role author
author2 Boyer,Leslie V
Alagón,Alejandro
author2_role author
author
dc.contributor.author.fl_str_mv Chippaux,Jean-Philippe
Boyer,Leslie V
Alagón,Alejandro
dc.subject.por.fl_str_mv Ebola
Epidemics
Immunotherapy
Prophylaxis
Africa
topic Ebola
Epidemics
Immunotherapy
Prophylaxis
Africa
description Background Better treatments are urgently needed for the management of Ebola virus epidemics in Equatorial Africa. Methods We conducted a systematic review of the literature on the use of passive immunotherapy for the treatment or prevention of Ebola virus disease. We placed findings from this review into the context of passive immunotherapy currently used for venom-induced disease, and recent improvements in manufacturing of polyvalent antivenom products. Results Passive immunotherapy appears to be one of the most promising specific treatments for Ebola. However, its potential has been incompletely evaluated, considering the overall experience and recent improvement of immunotherapy. Development and use of heterologous serum derivatives could protect people exposed to Ebola viruses with reasonable cost and logistics. Conclusion Hyperimmune equine IgG fragments and purified polyclonal whole IgG deserve further consideration as treatment for exposure to the Ebola virus.
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100203
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100203
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1186/s40409-015-0003-1
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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