In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203 |
Resumo: | Abstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. These venom peptides, called conopeptides, are classified into two main groups based on the number of cysteine residues, namely disulfide-rich and disulfide-poor conopeptides. Since disulfide-poor conotoxins are minor components of this venom cocktail, the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. This review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs. |
id |
UNESP-11_4a877459f95168e28747f4ca46e93f09 |
---|---|
oai_identifier_str |
oai:scielo:S1678-91992016000100203 |
network_acronym_str |
UNESP-11 |
network_name_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository_id_str |
|
spelling |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compoundsCone snailConopressinContryphanConantokinContulakinConorfamidConophanConomapConomarphinConolysinConoGAYConoCAPCono-NPYAbstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. These venom peptides, called conopeptides, are classified into two main groups based on the number of cysteine residues, namely disulfide-rich and disulfide-poor conopeptides. Since disulfide-poor conotoxins are minor components of this venom cocktail, the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. This review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-016-0083-6info:eu-repo/semantics/openAccessLebbe,Eline K. M.Tytgat,Janeng2017-02-15T00:00:00Zoai:scielo:S1678-91992016000100203Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2017-02-15T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
spellingShingle |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds Lebbe,Eline K. M. Cone snail Conopressin Contryphan Conantokin Contulakin Conorfamid Conophan Conomap Conomarphin Conolysin ConoGAY ConoCAP Cono-NPY |
title_short |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_full |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_fullStr |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_full_unstemmed |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
title_sort |
In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds |
author |
Lebbe,Eline K. M. |
author_facet |
Lebbe,Eline K. M. Tytgat,Jan |
author_role |
author |
author2 |
Tytgat,Jan |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Lebbe,Eline K. M. Tytgat,Jan |
dc.subject.por.fl_str_mv |
Cone snail Conopressin Contryphan Conantokin Contulakin Conorfamid Conophan Conomap Conomarphin Conolysin ConoGAY ConoCAP Cono-NPY |
topic |
Cone snail Conopressin Contryphan Conantokin Contulakin Conorfamid Conophan Conomap Conomarphin Conolysin ConoGAY ConoCAP Cono-NPY |
description |
Abstract During evolution, nature has embraced different strategies for species to survive. One strategy, applied by predators as diverse as snakes, scorpions, sea anemones and cone snails, is using venom to immobilize or kill a prey. This venom offers a unique and extensive source of chemical diversity as it is driven by the evolutionary pressure to improve prey capture and/or to protect their species. Cone snail venom is an example of the remarkable diversity in pharmacologically active small peptides that venoms can consist of. These venom peptides, called conopeptides, are classified into two main groups based on the number of cysteine residues, namely disulfide-rich and disulfide-poor conopeptides. Since disulfide-poor conotoxins are minor components of this venom cocktail, the number of identified peptides and the characterization of these peptides is far outclassed by its cysteine-rich equivalents. This review provides an overview of 12 families of disulfide-poor peptides identified to date as well as the state of affairs. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100203 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1186/s40409-016-0083-6 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958540033163264 |