Endogenous phospholipase A2 inhibitors in snakes: a brief overview

Detalhes bibliográficos
Autor(a) principal: Campos,Patrícia Cota
Data de Publicação: 2016
Outros Autores: Melo,Lutiana Amaral de, Dias,Gabriel Latorre Fortes, Fortes-Dias,Consuelo Latorre
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100204
Resumo: Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes – namely sbαPLI, sbβPLI or sbγPLI – depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs and sbγPLIs, whereas sbβPLIs are rare. When the target PLA2 is a Lys49 homolog or an Asp49 myotoxin, the sbPLI is denominated a myotoxin inhibitor protein (MIP). In this brief overview, the most relevant data on sbPLIs will be presented. Representative examples of sbαPLIs and sbγPLIs from two Old World – Gloydius brevicaudus and Malayopython reticulatus – and two New World – Bothrops alternatus and Crotalus durissus terrificus – snake species will be emphasized.
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spelling Endogenous phospholipase A2 inhibitors in snakes: a brief overviewPLA2 inhibitorPhospholipase A2Snake bloodNatural resistanceSnakesAbstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes – namely sbαPLI, sbβPLI or sbγPLI – depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs and sbγPLIs, whereas sbβPLIs are rare. When the target PLA2 is a Lys49 homolog or an Asp49 myotoxin, the sbPLI is denominated a myotoxin inhibitor protein (MIP). In this brief overview, the most relevant data on sbPLIs will be presented. Representative examples of sbαPLIs and sbγPLIs from two Old World – Gloydius brevicaudus and Malayopython reticulatus – and two New World – Bothrops alternatus and Crotalus durissus terrificus – snake species will be emphasized.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100204Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-016-0092-5info:eu-repo/semantics/openAccessCampos,Patrícia CotaMelo,Lutiana Amaral deDias,Gabriel Latorre FortesFortes-Dias,Consuelo Latorreeng2017-01-16T00:00:00Zoai:scielo:S1678-91992016000100204Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2017-01-16T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Endogenous phospholipase A2 inhibitors in snakes: a brief overview
title Endogenous phospholipase A2 inhibitors in snakes: a brief overview
spellingShingle Endogenous phospholipase A2 inhibitors in snakes: a brief overview
Campos,Patrícia Cota
PLA2 inhibitor
Phospholipase A2
Snake blood
Natural resistance
Snakes
title_short Endogenous phospholipase A2 inhibitors in snakes: a brief overview
title_full Endogenous phospholipase A2 inhibitors in snakes: a brief overview
title_fullStr Endogenous phospholipase A2 inhibitors in snakes: a brief overview
title_full_unstemmed Endogenous phospholipase A2 inhibitors in snakes: a brief overview
title_sort Endogenous phospholipase A2 inhibitors in snakes: a brief overview
author Campos,Patrícia Cota
author_facet Campos,Patrícia Cota
Melo,Lutiana Amaral de
Dias,Gabriel Latorre Fortes
Fortes-Dias,Consuelo Latorre
author_role author
author2 Melo,Lutiana Amaral de
Dias,Gabriel Latorre Fortes
Fortes-Dias,Consuelo Latorre
author2_role author
author
author
dc.contributor.author.fl_str_mv Campos,Patrícia Cota
Melo,Lutiana Amaral de
Dias,Gabriel Latorre Fortes
Fortes-Dias,Consuelo Latorre
dc.subject.por.fl_str_mv PLA2 inhibitor
Phospholipase A2
Snake blood
Natural resistance
Snakes
topic PLA2 inhibitor
Phospholipase A2
Snake blood
Natural resistance
Snakes
description Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins, although the carbohydrate moiety may not be essential for PLA2 inhibition in every case. The presently known sbPLIs belong to one of three structural classes – namely sbαPLI, sbβPLI or sbγPLI – depending on the presence of characteristic C-type lectin-like domains, leucine-rich repeats or three-finger motifs, respectively. Currently, the most numerous inhibitors described in the literature are sbαPLIs and sbγPLIs, whereas sbβPLIs are rare. When the target PLA2 is a Lys49 homolog or an Asp49 myotoxin, the sbPLI is denominated a myotoxin inhibitor protein (MIP). In this brief overview, the most relevant data on sbPLIs will be presented. Representative examples of sbαPLIs and sbγPLIs from two Old World – Gloydius brevicaudus and Malayopython reticulatus – and two New World – Bothrops alternatus and Crotalus durissus terrificus – snake species will be emphasized.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100204
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100204
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1186/s40409-016-0092-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.22 2016
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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