Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice

Detalhes bibliográficos
Autor(a) principal: Oliveira,LRC
Data de Publicação: 2012
Outros Autores: Picka,MCM, Nicolete,VC, Calvi,SA, Marcondes-Machado,J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005
Resumo: The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis.
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spelling Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c miceTrypanosoma cruziPCRhemocultureorgansdistributionThe aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005Journal of Venomous Animals and Toxins including Tropical Diseases v.18 n.1 2012reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992012000100005info:eu-repo/semantics/openAccessOliveira,LRCPicka,MCMNicolete,VCCalvi,SAMarcondes-Machado,Jeng2012-03-16T00:00:00Zoai:scielo:S1678-91992012000100005Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2012-03-16T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
title Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
spellingShingle Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
Oliveira,LRC
Trypanosoma cruzi
PCR
hemoculture
organs
distribution
title_short Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
title_full Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
title_fullStr Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
title_full_unstemmed Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
title_sort Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
author Oliveira,LRC
author_facet Oliveira,LRC
Picka,MCM
Nicolete,VC
Calvi,SA
Marcondes-Machado,J
author_role author
author2 Picka,MCM
Nicolete,VC
Calvi,SA
Marcondes-Machado,J
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,LRC
Picka,MCM
Nicolete,VC
Calvi,SA
Marcondes-Machado,J
dc.subject.por.fl_str_mv Trypanosoma cruzi
PCR
hemoculture
organs
distribution
topic Trypanosoma cruzi
PCR
hemoculture
organs
distribution
description The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992012000100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.18 n.1 2012
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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