Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005 |
Resumo: | The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. |
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The Journal of venomous animals and toxins including tropical diseases (Online) |
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|
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Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c miceTrypanosoma cruziPCRhemocultureorgansdistributionThe aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2012-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005Journal of Venomous Animals and Toxins including Tropical Diseases v.18 n.1 2012reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992012000100005info:eu-repo/semantics/openAccessOliveira,LRCPicka,MCMNicolete,VCCalvi,SAMarcondes-Machado,Jeng2012-03-16T00:00:00Zoai:scielo:S1678-91992012000100005Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2012-03-16T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
spellingShingle |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice Oliveira,LRC Trypanosoma cruzi PCR hemoculture organs distribution |
title_short |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_full |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_fullStr |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_full_unstemmed |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_sort |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
author |
Oliveira,LRC |
author_facet |
Oliveira,LRC Picka,MCM Nicolete,VC Calvi,SA Marcondes-Machado,J |
author_role |
author |
author2 |
Picka,MCM Nicolete,VC Calvi,SA Marcondes-Machado,J |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,LRC Picka,MCM Nicolete,VC Calvi,SA Marcondes-Machado,J |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi PCR hemoculture organs distribution |
topic |
Trypanosoma cruzi PCR hemoculture organs distribution |
description |
The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1678-91992012000100005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.18 n.1 2012 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958539190108160 |