Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/s1678-91992012000100005 http://hdl.handle.net/11449/226757 |
Resumo: | The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. © CEVAP 2012. |
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Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c miceDistributionHemocultureOrgansPCRTrypanosoma cruziThe aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. © CEVAP 2012.Department of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateDepartment of Tropical Diseases Botucatu Medical School São Paulo State University (UNESP - Univ Estadual Paulista), Botucatu, São Paulo StateUniversidade Estadual Paulista (UNESP)de Oliveira, Larissa Ragozo Cardoso [UNESP]Picka, M. C.M. [UNESP]Nicolete, V. C. [UNESP]Calvi, S. A. [UNESP]Marcondes-Machado, J. [UNESP]2022-04-29T02:55:23Z2022-04-29T02:55:23Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article34-43http://dx.doi.org/10.1590/s1678-91992012000100005Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 18, n. 1, p. 34-43, 2012.1678-91991678-9180http://hdl.handle.net/11449/22675710.1590/s1678-919920120001000052-s2.0-84859015196Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2024-08-15T15:23:27Zoai:repositorio.unesp.br:11449/226757Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
spellingShingle |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice de Oliveira, Larissa Ragozo Cardoso [UNESP] Distribution Hemoculture Organs PCR Trypanosoma cruzi |
title_short |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_full |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_fullStr |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_full_unstemmed |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
title_sort |
Organ tropism during the acute and chronic phases of Trypanosoma cruzi infection in BALB/c mice |
author |
de Oliveira, Larissa Ragozo Cardoso [UNESP] |
author_facet |
de Oliveira, Larissa Ragozo Cardoso [UNESP] Picka, M. C.M. [UNESP] Nicolete, V. C. [UNESP] Calvi, S. A. [UNESP] Marcondes-Machado, J. [UNESP] |
author_role |
author |
author2 |
Picka, M. C.M. [UNESP] Nicolete, V. C. [UNESP] Calvi, S. A. [UNESP] Marcondes-Machado, J. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
de Oliveira, Larissa Ragozo Cardoso [UNESP] Picka, M. C.M. [UNESP] Nicolete, V. C. [UNESP] Calvi, S. A. [UNESP] Marcondes-Machado, J. [UNESP] |
dc.subject.por.fl_str_mv |
Distribution Hemoculture Organs PCR Trypanosoma cruzi |
topic |
Distribution Hemoculture Organs PCR Trypanosoma cruzi |
description |
The aim of the present study was to investigate the presence of Trypanosoma cruzi in the heart, liver, lung, and kidneys, using hemoculture and PCR analysis, of mice infected with different parasite strains during the acute and chronic phases of infection. Parasitemia curves revealed strain-specific biological behaviors. For the Y and JLP strains, the acute phase of infection started at days six and ten post-infection, parasitemia peaked at days seven and 15 post-infection, the chronic phase started at days nine and 28 post-infection, and animals started dying at days 19 and 120 post-infection, respectively. When the two strains were compared, the JLP strain exhibited reduced and slower replication rates associated with a delayed peak of parasitism and reduced parasite burdens. However, parasites were detected in all studied organs using PCR analysis. The capacity of both strains to infect different organs likely influences disease pathogenesis. © CEVAP 2012. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2022-04-29T02:55:23Z 2022-04-29T02:55:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s1678-91992012000100005 Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 18, n. 1, p. 34-43, 2012. 1678-9199 1678-9180 http://hdl.handle.net/11449/226757 10.1590/s1678-91992012000100005 2-s2.0-84859015196 |
url |
http://dx.doi.org/10.1590/s1678-91992012000100005 http://hdl.handle.net/11449/226757 |
identifier_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 18, n. 1, p. 34-43, 2012. 1678-9199 1678-9180 10.1590/s1678-91992012000100005 2-s2.0-84859015196 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins Including Tropical Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
34-43 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128202854367232 |