The anti-osteoporotic effect of Moringa oleifera leaves extract on glucocorticoids-induced jawbone osteoporosis in Albino rats

• Autor(a) principal: Soliman, Tasneem
• Data de Publicação: 2021
• Outros Autores: Ali, Zoba, Zayed, Mohamed, Sabry, Dina, AbuBakr, Nermeen
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Dental Science
• Texto Completo: https://ojs.ict.unesp.br/index.php/cob/article/view/2876

Objective: Glucocorticoids induced osteoporosis and its related fragility fractures represent a costly humanand socioeconomic load worldwide. All the current pharmacological therapies possess multiple adverse effectsand high cost. Thus, the pesent study aimed to evaluate the bone healing ability of Moringa oleifera (MO) onglucocorticoids induced osteoporosis in the jawbone of Albino rats. Material and Methods: Osteoporosis wasprompted by a daily intraperitoneal injection of 200 micro g/ 100 g dexamethasone for 30 days. Next,the animalswere randomly divided into 2 groups; osteoporotic and MO treated group. The treated group receivd a dailyoral dose of 200mg/kg of MO. Rats from the MO group were sacrificed after 4 weeks from the beginning oftreatment, and the same sacrifice date was used for the osteoporotic group. Bone regeneration was evaluated bydual energy x-ray absorptiometry (DEXA), real time polymerase chain reaction (RT-PCR), histopathological andhistomorphometric examination. Results: After the sacrifice, the DEXA analysis revealed a significant upregulationin the BMD in the MO treated group (p <0.001). The RT-PCR test showed a significant decline in RANKL geneexpression and a significant rise in OPG gene expression in the MO group (p < 0.001, p = 0.002, respectively).The histopathological examination of the MO group displayed a marked healing of the jawbone micro-anatomy.The histomorphometric analysis also showed that the bone area percentage increased significantly in the MOgroup (p <0.05). Conclusion: A cheap, easy to get, yet a powerful plant like MO leaves, can be cosidered aneffective treatment for osteoporosis.KEYWORDSBone regeneration; Glucocorticoids; Moringa oleifera; Osteoporosis.