Oral ID® as an adjunctive tool for surgical margin assessment in patients with oral squamous cell carcinoma: a comparative study: Oral ID® as an Adjunctive Tool for Surgical Margin Assessment

• Autor(a) principal: Mohamed, Yasmeen
• Data de Publicação: 2022
• Outros Autores: Mohammed, Sawsan, Sulaiman, Ahmed
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Dental Science
• Texto Completo: https://ojs.ict.unesp.br/index.php/cob/article/view/2868

Objective: The condition of the resected margin in oral squamous cell carcinoma continues to be an importantprognostic factor; the use of optic technology could help surgeons in determining the margin status at real time.This study aims to evaluate Oral ID, a hand held device that uses the principal of auto-fluorescence to determinesurgical safe margins in patients with oral squamous cell carcinoma, and to compare the results with those of theconventional 1 cm margin method. Material and Methods: This study was a descriptive, comparative analyticalstudy carried out at Khartoum Dental Teaching Hospital and Oral Histopathology Diagnostic Laboratory, Facultyof Dentistry, University of Khartoum. A total of 92 margins obtained from 31 patients, 46 margins were taken byOral ID and the other 46 were taken by the traditional 1cm method. All margins were examined histologicallywith conventional Hematoxylin and Eosin stain. Results: It was found that all tumors showed fluorescence loss; Asignificant association was found between the use of Oral ID and obtaining a free margin P (0.02) the sensitivityof Oral ID was found to be 74% the specificity was found to be 89%. Ten out of the 46 margins obtained byfluorescence showed mild dysplasia and two margins showed high grade dysplasia. The 46 margins obtainedby the traditional 1cm margin showed different field alterations two were involved, one was close, five showedhigh grade dysplasia and 14 showed mild dysplasia yielding a specificity of 52.2%. Conclusion: Using Oral IDfor surgical margin assessment increases the accuracy to 74% compared to the conventional method which wasfound to be 52.2%. The results of the device are comparable to other auto-fluorescence devices of differenttrademarks. Further development of the device to help overcome its limitations is strongly advised. KEYWORDSOral ID; Auto-fluorescence; Cancer; Diagnosis; Oral squamous cell carcinoma.