Potentiometric determination of alendronate in pharmaceutical formulations

Detalhes bibliográficos
Autor(a) principal: De Haro Moreno, Andréia [UNESP]
Data de Publicação: 2004
Outros Autores: Pezza, Helena Redigolo [UNESP], Pezza, Leonardo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/231758
Resumo: A simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 μg mL-1. In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.
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spelling Potentiometric determination of alendronate in pharmaceutical formulationsAlendronatePharmaceutical formulationsPotentiometric determinationA simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 μg mL-1. In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.Instituto de Química UNESP, P.O.Box 355, CEP 14801-970, Araraquara, SPInstituto de Química UNESP, P.O.Box 355, CEP 14801-970, Araraquara, SPUniversidade Estadual Paulista (UNESP)De Haro Moreno, Andréia [UNESP]Pezza, Helena Redigolo [UNESP]Pezza, Leonardo [UNESP]2022-04-29T08:47:20Z2022-04-29T08:47:20Z2004-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article351-357Chemia Analityczna, v. 49, n. 3, p. 351-357, 2004.0009-2223http://hdl.handle.net/11449/2317582-s2.0-19544366456Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemia Analitycznainfo:eu-repo/semantics/openAccess2022-04-29T08:47:20Zoai:repositorio.unesp.br:11449/231758Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:43:18.048943Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Potentiometric determination of alendronate in pharmaceutical formulations
title Potentiometric determination of alendronate in pharmaceutical formulations
spellingShingle Potentiometric determination of alendronate in pharmaceutical formulations
De Haro Moreno, Andréia [UNESP]
Alendronate
Pharmaceutical formulations
Potentiometric determination
title_short Potentiometric determination of alendronate in pharmaceutical formulations
title_full Potentiometric determination of alendronate in pharmaceutical formulations
title_fullStr Potentiometric determination of alendronate in pharmaceutical formulations
title_full_unstemmed Potentiometric determination of alendronate in pharmaceutical formulations
title_sort Potentiometric determination of alendronate in pharmaceutical formulations
author De Haro Moreno, Andréia [UNESP]
author_facet De Haro Moreno, Andréia [UNESP]
Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
author_role author
author2 Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv De Haro Moreno, Andréia [UNESP]
Pezza, Helena Redigolo [UNESP]
Pezza, Leonardo [UNESP]
dc.subject.por.fl_str_mv Alendronate
Pharmaceutical formulations
Potentiometric determination
topic Alendronate
Pharmaceutical formulations
Potentiometric determination
description A simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 μg mL-1. In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-01
2022-04-29T08:47:20Z
2022-04-29T08:47:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Chemia Analityczna, v. 49, n. 3, p. 351-357, 2004.
0009-2223
http://hdl.handle.net/11449/231758
2-s2.0-19544366456
identifier_str_mv Chemia Analityczna, v. 49, n. 3, p. 351-357, 2004.
0009-2223
2-s2.0-19544366456
url http://hdl.handle.net/11449/231758
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Chemia Analityczna
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 351-357
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129545864216576

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