Spectrophotometric determination of methyldopa in pharmaceutical formulations

Detalhes bibliográficos
Autor(a) principal: Ribeiro,P. R. S.
Data de Publicação: 2005
Outros Autores: Pezza,L., Pezza,H. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Eclética Química
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702005000300003
Resumo: A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 µg ml-1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.
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spelling Spectrophotometric determination of methyldopa in pharmaceutical formulationsmethyldopaspectrophotometric determinationpharmaceuticals formulationsammonium molybdateA new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 µg ml-1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2005-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702005000300003Eclética Química v.30 n.3 2005reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702005000300003info:eu-repo/semantics/openAccessRibeiro,P. R. S.Pezza,L.Pezza,H. R.eng2005-11-17T00:00:00Zoai:scielo:S0100-46702005000300003Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2005-11-17T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false
dc.title.none.fl_str_mv Spectrophotometric determination of methyldopa in pharmaceutical formulations
title Spectrophotometric determination of methyldopa in pharmaceutical formulations
spellingShingle Spectrophotometric determination of methyldopa in pharmaceutical formulations
Ribeiro,P. R. S.
methyldopa
spectrophotometric determination
pharmaceuticals formulations
ammonium molybdate
title_short Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_full Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_fullStr Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_full_unstemmed Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_sort Spectrophotometric determination of methyldopa in pharmaceutical formulations
author Ribeiro,P. R. S.
author_facet Ribeiro,P. R. S.
Pezza,L.
Pezza,H. R.
author_role author
author2 Pezza,L.
Pezza,H. R.
author2_role author
author
dc.contributor.author.fl_str_mv Ribeiro,P. R. S.
Pezza,L.
Pezza,H. R.
dc.subject.por.fl_str_mv methyldopa
spectrophotometric determination
pharmaceuticals formulations
ammonium molybdate
topic methyldopa
spectrophotometric determination
pharmaceuticals formulations
ammonium molybdate
description A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 µg ml-1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.
publishDate 2005
dc.date.none.fl_str_mv 2005-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702005000300003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702005000300003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-46702005000300003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
dc.source.none.fl_str_mv Eclética Química v.30 n.3 2005
reponame:Eclética Química
instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Eclética Química
collection Eclética Química
repository.name.fl_str_mv Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
repository.mail.fl_str_mv ecletica@ctrlk.com.br||ecletica@iq.unesp.br
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