Spectrophotometric determination of methyldopa in pharmaceutical formulations

Detalhes bibliográficos
Autor(a) principal: Ribeiro, P. R S [UNESP]
Data de Publicação: 2005
Outros Autores: Pezza, Leonardo [UNESP], Pezza, Helena Redigolo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-46702005000300003
http://hdl.handle.net/11449/68304
Resumo: A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 μg ml -1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.
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spelling Spectrophotometric determination of methyldopa in pharmaceutical formulationsAmmonium molybdateMethyldopaPharmaceuticals formulationsSpectrophotometric determinationA new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 μg ml -1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.Instituto de Química - UNESP, P.O.Box 355, CEP 14801-970, Araraquara, SPInstituto de Química - UNESP, P.O.Box 355, CEP 14801-970, Araraquara, SPUniversidade Estadual Paulista (Unesp)Ribeiro, P. R S [UNESP]Pezza, Leonardo [UNESP]Pezza, Helena Redigolo [UNESP]2014-05-27T11:21:22Z2014-05-27T11:21:22Z2005-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article23-28application/pdfhttp://dx.doi.org/10.1590/S0100-46702005000300003Ecletica Quimica, v. 30, n. 3, p. 23-28, 2005.0100-4670http://hdl.handle.net/11449/6830410.1590/S0100-46702005000300003S0100-467020050003000032-s2.0-311444345282-s2.0-31144434528.pdf597890859185352431921250983611210000-0003-0197-7369Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEclética Químicainfo:eu-repo/semantics/openAccess2023-12-31T06:17:19Zoai:repositorio.unesp.br:11449/68304Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:45:57.692720Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Spectrophotometric determination of methyldopa in pharmaceutical formulations
title Spectrophotometric determination of methyldopa in pharmaceutical formulations
spellingShingle Spectrophotometric determination of methyldopa in pharmaceutical formulations
Ribeiro, P. R S [UNESP]
Ammonium molybdate
Methyldopa
Pharmaceuticals formulations
Spectrophotometric determination
title_short Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_full Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_fullStr Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_full_unstemmed Spectrophotometric determination of methyldopa in pharmaceutical formulations
title_sort Spectrophotometric determination of methyldopa in pharmaceutical formulations
author Ribeiro, P. R S [UNESP]
author_facet Ribeiro, P. R S [UNESP]
Pezza, Leonardo [UNESP]
Pezza, Helena Redigolo [UNESP]
author_role author
author2 Pezza, Leonardo [UNESP]
Pezza, Helena Redigolo [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ribeiro, P. R S [UNESP]
Pezza, Leonardo [UNESP]
Pezza, Helena Redigolo [UNESP]
dc.subject.por.fl_str_mv Ammonium molybdate
Methyldopa
Pharmaceuticals formulations
Spectrophotometric determination
topic Ammonium molybdate
Methyldopa
Pharmaceuticals formulations
Spectrophotometric determination
description A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 μg ml -1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.
publishDate 2005
dc.date.none.fl_str_mv 2005-07-01
2014-05-27T11:21:22Z
2014-05-27T11:21:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-46702005000300003
Ecletica Quimica, v. 30, n. 3, p. 23-28, 2005.
0100-4670
http://hdl.handle.net/11449/68304
10.1590/S0100-46702005000300003
S0100-46702005000300003
2-s2.0-31144434528
2-s2.0-31144434528.pdf
5978908591853524
3192125098361121
0000-0003-0197-7369
url http://dx.doi.org/10.1590/S0100-46702005000300003
http://hdl.handle.net/11449/68304
identifier_str_mv Ecletica Quimica, v. 30, n. 3, p. 23-28, 2005.
0100-4670
10.1590/S0100-46702005000300003
S0100-46702005000300003
2-s2.0-31144434528
2-s2.0-31144434528.pdf
5978908591853524
3192125098361121
0000-0003-0197-7369
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eclética Química
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 23-28
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129355411357696

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