Potentiometric determination of Minoxidil in topical use pharmaceutical samples

Detalhes bibliográficos
Autor(a) principal: Sousa,Rogério Adelino de
Data de Publicação: 2009
Outros Autores: Cavalheiro,Éder Tadeu Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Eclética Química
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702009000200003
Resumo: A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.
id UNESP-29_fa24d286dd5d1c465b77d4517e2d956c
oai_identifier_str oai:scielo:S0100-46702009000200003
network_acronym_str UNESP-29
network_name_str Eclética Química
repository_id_str
spelling Potentiometric determination of Minoxidil in topical use pharmaceutical samplesMinoxidil determinationtitrationpotenciometryA potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702009000200003Eclética Química v.34 n.2 2009reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702009000200003info:eu-repo/semantics/openAccessSousa,Rogério Adelino deCavalheiro,Éder Tadeu Gomeseng2010-02-08T00:00:00Zoai:scielo:S0100-46702009000200003Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2010-02-08T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false
dc.title.none.fl_str_mv Potentiometric determination of Minoxidil in topical use pharmaceutical samples
title Potentiometric determination of Minoxidil in topical use pharmaceutical samples
spellingShingle Potentiometric determination of Minoxidil in topical use pharmaceutical samples
Sousa,Rogério Adelino de
Minoxidil determination
titration
potenciometry
title_short Potentiometric determination of Minoxidil in topical use pharmaceutical samples
title_full Potentiometric determination of Minoxidil in topical use pharmaceutical samples
title_fullStr Potentiometric determination of Minoxidil in topical use pharmaceutical samples
title_full_unstemmed Potentiometric determination of Minoxidil in topical use pharmaceutical samples
title_sort Potentiometric determination of Minoxidil in topical use pharmaceutical samples
author Sousa,Rogério Adelino de
author_facet Sousa,Rogério Adelino de
Cavalheiro,Éder Tadeu Gomes
author_role author
author2 Cavalheiro,Éder Tadeu Gomes
author2_role author
dc.contributor.author.fl_str_mv Sousa,Rogério Adelino de
Cavalheiro,Éder Tadeu Gomes
dc.subject.por.fl_str_mv Minoxidil determination
titration
potenciometry
topic Minoxidil determination
titration
potenciometry
description A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702009000200003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702009000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-46702009000200003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
dc.source.none.fl_str_mv Eclética Química v.34 n.2 2009
reponame:Eclética Química
instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Eclética Química
collection Eclética Química
repository.name.fl_str_mv Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
repository.mail.fl_str_mv ecletica@ctrlk.com.br||ecletica@iq.unesp.br
_version_ 1754734618531069952

Registros relacionados