Humic Substances: Possibility of New Therapeutic Application
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira Multidisciplinar |
Texto Completo: | http://revistarebram.com/index.php/revistauniara/article/view/168 |
Resumo: | Humic substances (HS) are heterogeneous molecular aggregates, which have no defined structure and constitute the principal fraction of natural organic matter. They can act as complexation agents, due to their high density of functional groups, and therefore directly influence the transport, accumulation, bioavailability and toxicity of different substances. Metals are important environmental pollutants, since they are widely used during human activities, and following release are not either chemically or biologically degraded. Treatment of acute poisoning in humans caused by potentially toxic metals has employed complexation agents such as ethylenediaminetetraacetic acid (EDTA) or -aminoacids. However, some limitations of these materials such as the lack of selectivity of EDTA and the high cost of -aminoacids have provided the incentive for a search for alternatives. Previous studies of the properties of HS indicate their possible use as an alternative to these chelanting agents. |
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Humic Substances: Possibility of New Therapeutic ApplicationSubstâncias Húmicas: Possibilidade de um Novo Agente TerapêuticoHumic substancesPotentially toxic metalsChelating agents.Substâncias húmicasMetais potencialmente tóxicosAgentes quelantes.Humic substances (HS) are heterogeneous molecular aggregates, which have no defined structure and constitute the principal fraction of natural organic matter. They can act as complexation agents, due to their high density of functional groups, and therefore directly influence the transport, accumulation, bioavailability and toxicity of different substances. Metals are important environmental pollutants, since they are widely used during human activities, and following release are not either chemically or biologically degraded. Treatment of acute poisoning in humans caused by potentially toxic metals has employed complexation agents such as ethylenediaminetetraacetic acid (EDTA) or -aminoacids. However, some limitations of these materials such as the lack of selectivity of EDTA and the high cost of -aminoacids have provided the incentive for a search for alternatives. Previous studies of the properties of HS indicate their possible use as an alternative to these chelanting agents.Substâncias húmicas (SH) são agregados moleculares heterogêneos, possuem estrutura indefinida e constituem a principal fração da matéria orgânica natural. Devido ao elevado número de grupos funcionais presentes em sua estrutura, podem atuar como agentes complexantes, influenciando diretamente o transporte, acúmulo, biodisponibilidade e toxicidade de diferentes substâncias. Dentre os contaminantes ambientais, se destacam os metais, pela sua ampla aplicabilidade em diferentes setores e por não sofrerem degradação química ou biológica. O tratamento de intoxicações por metais potencialmente tóxicos em seres humanos vem sendo realizado por agentes complexantes, como o etilenodiaminotetraácetico (EDTA) e os -aminoácidos. Entretanto, algumas limitações, como a falta de seletividade do EDTA e o elevado custo dos -aminoácidos, têm incentivado a busca por outras substâncias quelantes. Nesse sentido, este artigo aborda as principais propriedades descritas na literatura que tornam as substâncias húmicas uma interessante alternativa como agente terapêutico, em casos de intoxicações por metais potencialmente tóxicos.Revista Brasileira Multidisciplinar - ReBraM2009-01-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistarebram.com/index.php/revistauniara/article/view/16810.25061/2527-2675/ReBraM/2009.v12i2.168Revista Brasileira Multidisciplinar - ReBraM; v. 12 n. 2 (2009): Julho-Dez; 205-2262527-26751415-3580reponame:Revista Brasileira Multidisciplinarinstname:Universidade de Araraquara (UNIARA)instacron:UNIARAporhttp://revistarebram.com/index.php/revistauniara/article/view/168/138Ferreira, Natália Noronhados Santos, AdemirRibeiro, Maria LuciaOliveira, Luciana Camargo deBotero, Wander GustavoRocha, Julio Cesarinfo:eu-repo/semantics/openAccess2018-07-11T12:39:13Zoai:ojs.revistarebram.com:article/168Revistahttp://revistarebram.com/index.php/revistauniaraPRIhttps://revistarebram.com/index.php/revistauniara/oairevistauniara@uniara.com||2527-26752527-2675opendoar:2018-07-11T12:39:13Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA)false |
dc.title.none.fl_str_mv |
Humic Substances: Possibility of New Therapeutic Application Substâncias Húmicas: Possibilidade de um Novo Agente Terapêutico |
title |
Humic Substances: Possibility of New Therapeutic Application |
spellingShingle |
Humic Substances: Possibility of New Therapeutic Application Ferreira, Natália Noronha Humic substances Potentially toxic metals Chelating agents. Substâncias húmicas Metais potencialmente tóxicos Agentes quelantes. |
title_short |
Humic Substances: Possibility of New Therapeutic Application |
title_full |
Humic Substances: Possibility of New Therapeutic Application |
title_fullStr |
Humic Substances: Possibility of New Therapeutic Application |
title_full_unstemmed |
Humic Substances: Possibility of New Therapeutic Application |
title_sort |
Humic Substances: Possibility of New Therapeutic Application |
author |
Ferreira, Natália Noronha |
author_facet |
Ferreira, Natália Noronha dos Santos, Ademir Ribeiro, Maria Lucia Oliveira, Luciana Camargo de Botero, Wander Gustavo Rocha, Julio Cesar |
author_role |
author |
author2 |
dos Santos, Ademir Ribeiro, Maria Lucia Oliveira, Luciana Camargo de Botero, Wander Gustavo Rocha, Julio Cesar |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Natália Noronha dos Santos, Ademir Ribeiro, Maria Lucia Oliveira, Luciana Camargo de Botero, Wander Gustavo Rocha, Julio Cesar |
dc.subject.por.fl_str_mv |
Humic substances Potentially toxic metals Chelating agents. Substâncias húmicas Metais potencialmente tóxicos Agentes quelantes. |
topic |
Humic substances Potentially toxic metals Chelating agents. Substâncias húmicas Metais potencialmente tóxicos Agentes quelantes. |
description |
Humic substances (HS) are heterogeneous molecular aggregates, which have no defined structure and constitute the principal fraction of natural organic matter. They can act as complexation agents, due to their high density of functional groups, and therefore directly influence the transport, accumulation, bioavailability and toxicity of different substances. Metals are important environmental pollutants, since they are widely used during human activities, and following release are not either chemically or biologically degraded. Treatment of acute poisoning in humans caused by potentially toxic metals has employed complexation agents such as ethylenediaminetetraacetic acid (EDTA) or -aminoacids. However, some limitations of these materials such as the lack of selectivity of EDTA and the high cost of -aminoacids have provided the incentive for a search for alternatives. Previous studies of the properties of HS indicate their possible use as an alternative to these chelanting agents. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://revistarebram.com/index.php/revistauniara/article/view/168 10.25061/2527-2675/ReBraM/2009.v12i2.168 |
url |
http://revistarebram.com/index.php/revistauniara/article/view/168 |
identifier_str_mv |
10.25061/2527-2675/ReBraM/2009.v12i2.168 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://revistarebram.com/index.php/revistauniara/article/view/168/138 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM |
publisher.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM |
dc.source.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM; v. 12 n. 2 (2009): Julho-Dez; 205-226 2527-2675 1415-3580 reponame:Revista Brasileira Multidisciplinar instname:Universidade de Araraquara (UNIARA) instacron:UNIARA |
instname_str |
Universidade de Araraquara (UNIARA) |
instacron_str |
UNIARA |
institution |
UNIARA |
reponame_str |
Revista Brasileira Multidisciplinar |
collection |
Revista Brasileira Multidisciplinar |
repository.name.fl_str_mv |
Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA) |
repository.mail.fl_str_mv |
revistauniara@uniara.com|| |
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1797174605052379136 |