Análise histopatológica dos efeitos do bioterapeutico 200dh em camundongos infectados por Trypanosoma cruzi

• Autor(a) principal: BARROS, Eduarda Pereira de
• Data de Publicação: 2021
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Digital Unicesumar
• Texto Completo: http://rdu.unicesumar.edu.br/handle/123456789/7576
• topic: Bioterápicos; Doença de Chagas; Homeopatia; T. cruzi; CNPQ::CIENCIAS DA SAUDE::MEDICINA

The trypanosoma cruzi is a protozoan that causes a serious infeccion in the vertebrate host, being capable of causing irreversible damages, mainly in the muscle cells, also known as trypanosomiasis disease or Chagas Disease. The commercially avaible drug medication wich fights this parasite is not completly eficiente and causes undesireble and irreversible damages, making it necessary to search for other fields of medicine, in terms of medication, to combat this disease. Therefore, research with homeopathic medicines has being promising in the fight against the parasite, especially the amastigote forms, which are more difficult to be exterminated. Biotherapics are the homeopathic ones that have been more successful in relation to T. cruzi infection, since these drugs have their active principle removed from the parasite itself, its toxins, part of its members, performing a therapy known as isotherapy - cure by the same. The work was carried out with analysis of 100 histological slides, in 'zigzag', 'listing cells, infected or not by amastigotes, as well as cells of innate or acquired immunity. The work had the existence of three groups: control, treated continuously and treated only at the beginning of the infection. The results indicates that the 200dH biotherapic acts by coercing the immune system to fight T. cruzi in contaminated guinea pigs, promoting a cellular and humoral imune response more efficient than the physiological one. It is believed that this medicine works by stimulating the defense cells, which will respond in an antigenspecific manner, favoring the fight against amastigotes. This process is probably initiated by the stimulation of the macrophage, which in turn, according to the remains found, initiates an inflammatory cascade, with predominance of the Th1 pathway, promoting the production of IL-4e IL-5 and γ interferon, helping to combat amastigotes. With this result, the cure for homeopathy, of an infectious disease, shows promise, being an innovative and important field of medicine, requiring further investigation.