Importance of secondary metabolites produced by actinobacteria

• Autor(a) principal: Costa Rosa, Fernanda
• Data de Publicação: 2023
• Outros Autores: Gonçalves Mota, Alexya, Lima de Almeida, Barbara, dos Santos de Souza, Gessiane, Carvalho Araújo, Maria, Franzoi Melo, Maycon Henrique, Silva dos Santos Aliança, Amanda, Miranda de Mendonça, Rita de Cássia
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Ciências da Saúde Ceuma
• Texto Completo: https://revcsaudeceuma.emnuvens.com.br/revista/article/view/6
• topic: Streptomyces; Metabólitos secundários; Endofíticos; Streptomyces; Secondary metabolites; Endophytes

This article consists of a literature review on the most relevant aspects of actinobacteria and their bioproducts. Actinobacteria are Gram-positive bacteria with morphological properties of fungal (aerial and vegetative mycelium) and bacterial cells. They are widely distributed in nature, being commonly isolated from soil, water, sediments, plants, decaying plants, root nodules, activated sludge, animal feces and food products; in addition to being distributed in aquatic habitats and extreme environments such as frozen areas, desert soils and abyssal zones, places considered ideal for microorganisms to produce secondary metabolites. About more than 23,000 microbial metabolites are known, of which 32% are produced by actinomycetes. Secondary metabolites can be used as a model for the synthesis and semi-synthesis of bioactive molecules with a broad spectrum and low toxicity. Therefore, there are several expected applications for actinobacteria, and increasingly the use of bioactive compounds, of natural origin, for the treatment of various diseases, are incorporated in the pharmaceutical industry. However, actinobacteria are still little studied, especially the endophytic ones, requiring more research in the area, as the literature still lacks in-depth studies on this theme.