Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant

Detalhes bibliográficos
Autor(a) principal: Schweich-Adami, Laynna de Carvalho
Data de Publicação: 2022
Outros Autores: Hermeto, Larissa Corrêa, Caramalac, Silvana Marques, Antoniolli-Silva, Andréia Conceição Milan Brochado, Oliveira, Rodrigo Juliano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/24669
Resumo: Introduction: Recent studies have investigated the use of adipose tissue as source of mesenchymal stem cells in the treatment of knee osteoarthritis in humans. However, there are still several protocols being performed. Objective: Analyze the protocols published in the literature in the last ten years and to investigate how they are being carried out and if they are following the criteria adopted by the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Methodology: Articles from the PubMed, ScienceDirect and Lilacs database published in January / 2010 until the present time, which were evaluated in order to investigate the use of adipose-derived stem cells in the treatment of knee osteoarthritis. Results: Thirty four articles were evaluated in its entiraty. The abdominal area was the most choosen to do the liposuction, however the quantities of adipose tissue removed and the number of cells transplanted was variable.  It is hightlited the enzimatic digestion of adipose tissue with collagenase as extraction method. Only 14 articles complied all the 3 criteria required to prove the real presence of mesenchymal stem cells in the samples that was transplanted. However, all the articles showed improvement of function and pain. Final considerations: Thus, even the results found are promising, the evidence is still limited in humans and the variability of the methodology makes it difficult to standardize the technique, also its implementation as a reference in the treatment of knee osteoarthritis.
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spelling Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplantCélulas madre derivadas de tejido adiposo en el tratamiento de la osteoartritis de rodilla: desde los métodos de extracción hasta la preparación del trasplanteCélulas-tronco derivadas do tecido adiposo no tratamento da osteoartrite do joelho: desde os métodos de extração até a preparação para o transplanteOsteoartriteJoelhoCélulas tronco mesenquimaisTecido adiposo.ArtrosisRodillaCélulas madre mesenquimalesTejido adiposo.OsteoarthritisKneeMesenchymal stem cellsAdipose tissue. Introduction: Recent studies have investigated the use of adipose tissue as source of mesenchymal stem cells in the treatment of knee osteoarthritis in humans. However, there are still several protocols being performed. Objective: Analyze the protocols published in the literature in the last ten years and to investigate how they are being carried out and if they are following the criteria adopted by the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Methodology: Articles from the PubMed, ScienceDirect and Lilacs database published in January / 2010 until the present time, which were evaluated in order to investigate the use of adipose-derived stem cells in the treatment of knee osteoarthritis. Results: Thirty four articles were evaluated in its entiraty. The abdominal area was the most choosen to do the liposuction, however the quantities of adipose tissue removed and the number of cells transplanted was variable.  It is hightlited the enzimatic digestion of adipose tissue with collagenase as extraction method. Only 14 articles complied all the 3 criteria required to prove the real presence of mesenchymal stem cells in the samples that was transplanted. However, all the articles showed improvement of function and pain. Final considerations: Thus, even the results found are promising, the evidence is still limited in humans and the variability of the methodology makes it difficult to standardize the technique, also its implementation as a reference in the treatment of knee osteoarthritis.Introducción: Estudios recientes han investigado el uso del tejido adiposo como fuente de células madre mesenquimales en el tratamiento de la osteoartritis de rodilla en humanos. Sin embargo, todavía existe mucha variabilidad en los protocolos existentes. Objetivo: Analizar los protocolos publicados en la literatura en los últimos diez años e investigar cómo se están llevando a cabo y seguir los criterios adoptados por la International Federation for Adipose Therapeutics and Science (IFATS) y por la International Society for Cellular Therapy (ISCT). .Metodología: Se evaluaron artículos de las bases de datos PubMed, ScienceDirect y Lilacs publicados en enero de 2010 hasta la fecha para investigar el uso de células madre derivadas del tejido adiposo en el tratamiento de la osteoartritis de rodilla. Resultados: Treinta y cuatro artículos fueron evaluados en su totalidad. La región abdominal fue la más elegida para la liposucción, pero la cantidad de tejido adiposo extraído y el número de células trasplantadas variaron. La digestión enzimática del tejido adiposo podría estimularse con colagenasa como método de extracción. Solo 14 artículos cumplieron los 3 criterios requeridos para probar la presencia real de células madre mesenquimales en las muestras trasplantadas. Sin embargo, todos los artículos mostraron una mejora en la función y el dolor. Consideraciones finales: Así, incluso los resultados encontrados son prometedores, la evidencia aún es limitada en humanos y la variabilidad de la metodología dificulta la estandarización de la técnica y su aplicación como referencia en el tratamiento de la artrosis de rodilla.Introdução: Estudos recentes investigaram a utilização do tecido adiposo como fonte de células tronco mesenquimais no tratamento da osteoartrite de joelho em humanos. No entanto, ainda existe muita variabilidade nos protocolos existentes. Objetivo: Analisar os protocolos publicados na literatura nos últimos dez anos e investigar como estão sendo realizados e se seguem os critérios adotados pela International Federation for Adipose Therapeutics and Science (IFATS) e pela International Society for Cellular Therapy (ISCT). Metodologia: Artigos das bases de dados PubMed, ScienceDirect e Lilacs publicados em janeiro / 2010 até o momento, foram avaliados, a fim de, investigar o uso de células tronco derivadas do tecido adiposo no tratamento da osteoartrite de joelho. Resultados: Trinta e quatro artigos foram avaliados na íntegra. A região abdominal foi a mais escolhida para a realização da lipoaspiração, porém as quantidades de tecido adiposo retiradas e o número de células transplantadas foram variáveis. A digestão enzimática do tecido adiposo com a colagenase durante o método de extração foi a forma mais utilizada. Apenas 14 artigos atenderam a todos os 3 critérios exigidos para comprovar a real presença de células tronco mesenquimais nas amostras transplantadas. No entanto, todos os artigos mostraram melhora da função e da dor.  Considerações finais: Assim, mesmo com os resultados promissores encontrados, as evidências ainda são limitadas em humanos. A variabilidade da metodologia dificulta a padronização da técnica impedindo assim que este tipo de terapia se torne referência no tratamento da osteoartrite do joelho.Research, Society and Development2022-01-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2466910.33448/rsd-v11i1.24669Research, Society and Development; Vol. 11 No. 1; e24111124699Research, Society and Development; Vol. 11 Núm. 1; e24111124699Research, Society and Development; v. 11 n. 1; e241111246992525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/24669/21847Copyright (c) 2022 Laynna de Carvalho Schweich-Adami; Larissa Corrêa Hermeto; Silvana Marques Caramalac; Andréia Conceição Milan Brochado Antoniolli-Silva; Rodrigo Juliano Oliveirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSchweich-Adami, Laynna de CarvalhoHermeto, Larissa CorrêaCaramalac, Silvana MarquesAntoniolli-Silva, Andréia Conceição Milan Brochado Oliveira, Rodrigo Juliano2022-01-16T18:08:18Zoai:ojs.pkp.sfu.ca:article/24669Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:09.008196Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
Células madre derivadas de tejido adiposo en el tratamiento de la osteoartritis de rodilla: desde los métodos de extracción hasta la preparación del trasplante
Células-tronco derivadas do tecido adiposo no tratamento da osteoartrite do joelho: desde os métodos de extração até a preparação para o transplante
title Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
spellingShingle Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
Schweich-Adami, Laynna de Carvalho
Osteoartrite
Joelho
Células tronco mesenquimais
Tecido adiposo.
Artrosis
Rodilla
Células madre mesenquimales
Tejido adiposo.
Osteoarthritis
Knee
Mesenchymal stem cells
Adipose tissue.
title_short Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
title_full Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
title_fullStr Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
title_full_unstemmed Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
title_sort Adipose-derived stem cells in the treatment of knee osteoarthritis: from extraction methods to the preparation of the transplant
author Schweich-Adami, Laynna de Carvalho
author_facet Schweich-Adami, Laynna de Carvalho
Hermeto, Larissa Corrêa
Caramalac, Silvana Marques
Antoniolli-Silva, Andréia Conceição Milan Brochado
Oliveira, Rodrigo Juliano
author_role author
author2 Hermeto, Larissa Corrêa
Caramalac, Silvana Marques
Antoniolli-Silva, Andréia Conceição Milan Brochado
Oliveira, Rodrigo Juliano
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Schweich-Adami, Laynna de Carvalho
Hermeto, Larissa Corrêa
Caramalac, Silvana Marques
Antoniolli-Silva, Andréia Conceição Milan Brochado
Oliveira, Rodrigo Juliano
dc.subject.por.fl_str_mv Osteoartrite
Joelho
Células tronco mesenquimais
Tecido adiposo.
Artrosis
Rodilla
Células madre mesenquimales
Tejido adiposo.
Osteoarthritis
Knee
Mesenchymal stem cells
Adipose tissue.
topic Osteoartrite
Joelho
Células tronco mesenquimais
Tecido adiposo.
Artrosis
Rodilla
Células madre mesenquimales
Tejido adiposo.
Osteoarthritis
Knee
Mesenchymal stem cells
Adipose tissue.
description Introduction: Recent studies have investigated the use of adipose tissue as source of mesenchymal stem cells in the treatment of knee osteoarthritis in humans. However, there are still several protocols being performed. Objective: Analyze the protocols published in the literature in the last ten years and to investigate how they are being carried out and if they are following the criteria adopted by the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Methodology: Articles from the PubMed, ScienceDirect and Lilacs database published in January / 2010 until the present time, which were evaluated in order to investigate the use of adipose-derived stem cells in the treatment of knee osteoarthritis. Results: Thirty four articles were evaluated in its entiraty. The abdominal area was the most choosen to do the liposuction, however the quantities of adipose tissue removed and the number of cells transplanted was variable.  It is hightlited the enzimatic digestion of adipose tissue with collagenase as extraction method. Only 14 articles complied all the 3 criteria required to prove the real presence of mesenchymal stem cells in the samples that was transplanted. However, all the articles showed improvement of function and pain. Final considerations: Thus, even the results found are promising, the evidence is still limited in humans and the variability of the methodology makes it difficult to standardize the technique, also its implementation as a reference in the treatment of knee osteoarthritis.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24669
10.33448/rsd-v11i1.24669
url https://rsdjournal.org/index.php/rsd/article/view/24669
identifier_str_mv 10.33448/rsd-v11i1.24669
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/24669/21847
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 1; e24111124699
Research, Society and Development; Vol. 11 Núm. 1; e24111124699
Research, Society and Development; v. 11 n. 1; e24111124699
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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