Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review

Detalhes bibliográficos
Autor(a) principal: Freire, Marco Aurelio M.
Data de Publicação: 2022
Outros Autores: Rocha, Gabriel S., Costa, Ianara M., Oliveira, Lucidio C., Guzen, Fausto P., Cavalcanti, Jose Rodolfo Lopes P.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/28861
Resumo: Compounds of natural origin have been used by the human species in the treatment of various diseases since the most remote times, with many active principles being isolated in recent years. One of these compounds, Astragaloside IV (AS-IV), obtained from the root extract of Astragalus membranaceus, a plant native to southwestern Asia, has been particularly studied, possessing anti-inflammatory, antioxidant, antibacterial and antiviral properties. In this sense, the aforementioned substance has become a component used in several models of Central Nervous System (CNS) diseases. In light of this, the present review aimed to describe the roles of this substance in models of altered states of the CNS, focusing on Alzheimer’s and Parkinson’s Diseases, stroke and traumatic brain injury, debilitating conditions that result in a severe impact on both socioeconomic and health care systems. The antioxidant, anti-inflammatory and anti-apoptotic actions of AS-IV were characterized in both in vitro and in vivo models in the distinct pathologies investigated, indicating that this substance emerges as an important element for the treatment of altered states of the CNS.
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spelling Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated reviewPapeles del terpenoide Astragaloside IV en estados alterados del sistema nervioso: una revisión atualizadaPapéis do terpenóide Astragalosídeo IV em estados alterados do sistema nervoso: uma revisão atualizadaPlantas medicinalesAstragalosido IVSistema nervioso centralNeurodegeneraciónNeuroprotecciónEnseñanza.Plantas medicinaisAstragalosídeo IVSistema Nervoso CentralNeurodegeneraçãoNeuroproteçãoEnsino.Medicinal plantsAstragaloside IVCentral Nervous SystemNeurodegenerationNeuroprotectionTeaching.Compounds of natural origin have been used by the human species in the treatment of various diseases since the most remote times, with many active principles being isolated in recent years. One of these compounds, Astragaloside IV (AS-IV), obtained from the root extract of Astragalus membranaceus, a plant native to southwestern Asia, has been particularly studied, possessing anti-inflammatory, antioxidant, antibacterial and antiviral properties. In this sense, the aforementioned substance has become a component used in several models of Central Nervous System (CNS) diseases. In light of this, the present review aimed to describe the roles of this substance in models of altered states of the CNS, focusing on Alzheimer’s and Parkinson’s Diseases, stroke and traumatic brain injury, debilitating conditions that result in a severe impact on both socioeconomic and health care systems. The antioxidant, anti-inflammatory and anti-apoptotic actions of AS-IV were characterized in both in vitro and in vivo models in the distinct pathologies investigated, indicating that this substance emerges as an important element for the treatment of altered states of the CNS.Los compuestos de origen natural han sido utilizados por la especie humana en el tratamiento de diversas enfermedades desde los tiempos más remotos, aislándose numerosos principios activos en los últimos años. Uno de estos compuestos, el Astragalosido IV (AS-IV), obtenido del extracto de raíz de Astragalus membranaceus, una planta originaria del suroeste de Asia, ha sido particularmente estudiado, poseyendo propiedades antiinflamatorias, antioxidantes, antibacterianas y antivirales. En este sentido, la mencionada sustancia se ha convertido en un componente utilizado en varios modelos de enfermedades del Sistema Nervioso Central (SNC). A la luz de esto, la presente revisión tuvo como objetivo descrebir los papeles de esta sustancia en modelos de estados alterados del SNC, en particular las enfermedades de Alzheimer y Parkinson, accidente cerebrovascular y lesión cerebral traumática, condiciones debilitantes que resultan en un impacto severo tanto en los sistemas socioeconómicos como de atención médica. Las acciones antioxidantes, antiinflamatorias y antiapoptóticas de AS-IV se caracterizaron en modelos in vitro e in vivo en las diferentes patologías investigadas, lo que indica que esta sustancia emerge como un elemento importante para el tratamiento de estados alterados del SNC.Compostos de origem natural têm sido empregados pela espécie humana no tratamento de diversos males desde os tempos mais remotos, com muitos princípios ativos sendo isolados em anos recentes. Um desses compostos, o Astragalosídeo IV (AS-IV), obtido do extrato da raiz do Astragalus membranaceus, planta nativa do sudoeste do continente asiático, tem sido particularmente estudado, devido possuir propriedades farmacológicas de ação anti-inflamatória, antioxidante, antibacteriana e antiviral. Nesse sentido, a substância supracitada tem se constituído em um fármaco utilizado em diversos modelos de doenças do Sistema Nervoso Central (SNC). À luz do exposto, a presente revisão objetivou descrever os papéis dessa substância em modelos de estados alterados do SNC, notadamente nas Doenças de Alzheimer e Parkinson, acidente vascular encefálico (AVE) e lesão traumática do cérebro, condições debilitantes que resultam em um severo impacto tanto em âmbito socioeconômico quanto para os sistemas de saúde. As ações antioxidante, anti-inflamatória e antiapoptótica do AS-IV foram caracterizadas em modelos in vitro e in vivo nas diferentes patologias investigadas, indicando que essa substância emerge como um elemento importante para o tratamento de estados alterados do SNC.Research, Society and Development2022-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2886110.33448/rsd-v11i6.28861Research, Society and Development; Vol. 11 No. 6; e11711628861Research, Society and Development; Vol. 11 Núm. 6; e11711628861Research, Society and Development; v. 11 n. 6; e117116288612525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/28861/25037Copyright (c) 2022 Marco Aurelio M. Freire; Gabriel S. Rocha; Ianara M. Costa; Lucidio C. Oliveira; Fausto P. Guzen; Jose Rodolfo Lopes P. Cavalcantihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFreire, Marco Aurelio M.Rocha, Gabriel S. Costa, Ianara M. Oliveira, Lucidio C. Guzen, Fausto P. Cavalcanti, Jose Rodolfo Lopes P. 2022-05-13T18:04:10Zoai:ojs.pkp.sfu.ca:article/28861Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:07.320968Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
Papeles del terpenoide Astragaloside IV en estados alterados del sistema nervioso: una revisión atualizada
Papéis do terpenóide Astragalosídeo IV em estados alterados do sistema nervoso: uma revisão atualizada
title Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
spellingShingle Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
Freire, Marco Aurelio M.
Plantas medicinales
Astragalosido IV
Sistema nervioso central
Neurodegeneración
Neuroprotección
Enseñanza.
Plantas medicinais
Astragalosídeo IV
Sistema Nervoso Central
Neurodegeneração
Neuroproteção
Ensino.
Medicinal plants
Astragaloside IV
Central Nervous System
Neurodegeneration
Neuroprotection
Teaching.
title_short Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
title_full Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
title_fullStr Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
title_full_unstemmed Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
title_sort Roles of terpenoid Astragaloside IV in altered states of the nervous system: an updated review
author Freire, Marco Aurelio M.
author_facet Freire, Marco Aurelio M.
Rocha, Gabriel S.
Costa, Ianara M.
Oliveira, Lucidio C.
Guzen, Fausto P.
Cavalcanti, Jose Rodolfo Lopes P.
author_role author
author2 Rocha, Gabriel S.
Costa, Ianara M.
Oliveira, Lucidio C.
Guzen, Fausto P.
Cavalcanti, Jose Rodolfo Lopes P.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Freire, Marco Aurelio M.
Rocha, Gabriel S.
Costa, Ianara M.
Oliveira, Lucidio C.
Guzen, Fausto P.
Cavalcanti, Jose Rodolfo Lopes P.
dc.subject.por.fl_str_mv Plantas medicinales
Astragalosido IV
Sistema nervioso central
Neurodegeneración
Neuroprotección
Enseñanza.
Plantas medicinais
Astragalosídeo IV
Sistema Nervoso Central
Neurodegeneração
Neuroproteção
Ensino.
Medicinal plants
Astragaloside IV
Central Nervous System
Neurodegeneration
Neuroprotection
Teaching.
topic Plantas medicinales
Astragalosido IV
Sistema nervioso central
Neurodegeneración
Neuroprotección
Enseñanza.
Plantas medicinais
Astragalosídeo IV
Sistema Nervoso Central
Neurodegeneração
Neuroproteção
Ensino.
Medicinal plants
Astragaloside IV
Central Nervous System
Neurodegeneration
Neuroprotection
Teaching.
description Compounds of natural origin have been used by the human species in the treatment of various diseases since the most remote times, with many active principles being isolated in recent years. One of these compounds, Astragaloside IV (AS-IV), obtained from the root extract of Astragalus membranaceus, a plant native to southwestern Asia, has been particularly studied, possessing anti-inflammatory, antioxidant, antibacterial and antiviral properties. In this sense, the aforementioned substance has become a component used in several models of Central Nervous System (CNS) diseases. In light of this, the present review aimed to describe the roles of this substance in models of altered states of the CNS, focusing on Alzheimer’s and Parkinson’s Diseases, stroke and traumatic brain injury, debilitating conditions that result in a severe impact on both socioeconomic and health care systems. The antioxidant, anti-inflammatory and anti-apoptotic actions of AS-IV were characterized in both in vitro and in vivo models in the distinct pathologies investigated, indicating that this substance emerges as an important element for the treatment of altered states of the CNS.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/28861
10.33448/rsd-v11i6.28861
url https://rsdjournal.org/index.php/rsd/article/view/28861
identifier_str_mv 10.33448/rsd-v11i6.28861
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/28861/25037
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 6; e11711628861
Research, Society and Development; Vol. 11 Núm. 6; e11711628861
Research, Society and Development; v. 11 n. 6; e11711628861
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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