Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα

Detalhes bibliográficos
Autor(a) principal: Carneiro, Suzana Alves Mundim
Data de Publicação: 2021
Outros Autores: Souza , Isabella Tavares, Silva , Raika Eduarda Rodrigues da, Pinto, Emerith Mayra Hungria, Freitas, Aline de Araújo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/15823
Resumo: The immunopathological mechanisms involved in the development of leprosy neural injury are not yet fully understood. Thus, the objective of this study was to perform an integrative review in order to identify the involvement of neurotrophin NGF and cytokine TNFα in the pathogenesis of neural injury in leprosy reactions. This review was carried out by search for scientific articles in the databases PubMed, SciELO and Google Acadêmico following the Descriptors of Health Science (DeCS) “Leprosy Reaction”, “Nerve Growth Factor (NGF)”, “Tumor Necrosis Factor- alpha (TNFα)”, and 28 articles was selected. The results showed that in the type 1 reaction there is tissue expression of IL-2, IFNg, TNFα, IL-12 and IL-1b. Whereas the type 2 or ENH reaction has been associated with high TNFα concentrations, neutrophilic infiltration and activation of complement system. High levels of NGF were observed in the lepromatous form of the disease and, low levels, in the tuberculoid form, since this stimulates the expression of TNFα, contributing to the evolution of neural lesions. There seems to be an interaction between NGF and TNFα, since NGF induces endogenous expression of TNFα and this positive feedback promotes a survival of healthy neural cells.
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spelling Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFαLesión neural hansénica: Papel de la neurotrofina NGF y la citoquina TNFα Lesão neural hansênica: Papel da neurotrofina NGF e da citocina TNFαReação hansênicaFator de crescimento neural (NGF)Fator de necrose tumoral alfa (TNF).Reacción a la lepraFactor de crescimento neural (NGF)Factor de necrosis tumoral alfa (TNF).Leprosy reactionNerve growth factor (NGF)Tumor necrosis factor- alpha (TNFα).The immunopathological mechanisms involved in the development of leprosy neural injury are not yet fully understood. Thus, the objective of this study was to perform an integrative review in order to identify the involvement of neurotrophin NGF and cytokine TNFα in the pathogenesis of neural injury in leprosy reactions. This review was carried out by search for scientific articles in the databases PubMed, SciELO and Google Acadêmico following the Descriptors of Health Science (DeCS) “Leprosy Reaction”, “Nerve Growth Factor (NGF)”, “Tumor Necrosis Factor- alpha (TNFα)”, and 28 articles was selected. The results showed that in the type 1 reaction there is tissue expression of IL-2, IFNg, TNFα, IL-12 and IL-1b. Whereas the type 2 or ENH reaction has been associated with high TNFα concentrations, neutrophilic infiltration and activation of complement system. High levels of NGF were observed in the lepromatous form of the disease and, low levels, in the tuberculoid form, since this stimulates the expression of TNFα, contributing to the evolution of neural lesions. There seems to be an interaction between NGF and TNFα, since NGF induces endogenous expression of TNFα and this positive feedback promotes a survival of healthy neural cells.Los mecanismos imunopatológicos implicados en el desarrollo de la lesión neural por lepra aún no se conocen por completo. Por tanto, el objetivo de este trabajo fue realizar una revisión integradora con el fin de identificar la implicación de la neurotrofina NGF y la citoquina TNFα en la patogenia de la lesión neural por lepra. Esta revisión se llevó a cabo mediante la búsqueda de artículos en las plataformas de indexación PubMed, SciELO y Google Scholar con los descriptores de ciencias de la salud (DeCS) “Lepra Reaction”, “Nerve Growth Factor (NGF)”, “Tumor Necrosis Factor-alpha (TNFα)”, obteniendo 28 artículos seleccionados. Los resultados mostraron que durante la reacción de tipo 1 hay expresión tisular de IL-2, IFNg, TNFα, IL-12 e IL-1b. La reacción tipo 2 o ENL, por otro lado, se ha asociado con altas concentraciones de TNFα, infiltración neutrofílica y activación del sistema del complemento. Se observaron niveles elevados de NGF en la forma lepromatosa y niveles bajos en la forma tuberculoide de la enfermedad, ya que este estimula la expresión de TNFα, lo que contribuye a la evolución de las lesiones neurales. Parece haber una interacción entre NGF y TNFα, ya que NGF induce la expresión endógena de TNFα y esta retroalimentación positiva promueve la supervivencia de las células neurales sanas.Os mecanismos imunopatológicos envolvidos no desenvolvimento de lesão neural hansênica ainda não são completamente esclarecidos. Sendo assim, o objetivo deste trabalho foi realizar uma revisão integrativa a fim de identificar o envolvimento da neurotrofina NGF e da citocina TNFα na patogênese da lesão neural hansênica. Esta revisão foi realizada mediante a busca de artigos nas plataformas indexadoras PubMed, SciELO e Google Acadêmico com os Descritores em Ciências da Saúde (DeCS) “Leprosy Reaction”, “Nerve Growth Factor (NGF)”, “Tumor Necrosis Factor- alpha (TNFα)”, sendo selecionados 28 artigos. Os resultados evidenciaram que durante a reação do tipo 1 há expressão tecidual de IL-2, IFN-g, TNFα, IL-12 e IL-1b. Já a reação do tipo 2 ou ENH tem sido associada com altas concentrações de TNFα, infiltração neutrofílica e ativação do sistema complemento. Altos níveis de NGF foram observados na forma lepromatosa e baixos níveis na forma tuberculoide da doença, pois nesta há estímulo da expressão de TNFα o que contribui para a evolução de lesões neurais. Parece haver uma interação entre NGF e TNFα, uma vez que o NGF induz a expressão endógena de TNFα e esse feedback positivo promove uma sobrevida das células neurais saudáveis.Research, Society and Development2021-05-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1582310.33448/rsd-v10i6.15823Research, Society and Development; Vol. 10 No. 6; e29010615823Research, Society and Development; Vol. 10 Núm. 6; e29010615823Research, Society and Development; v. 10 n. 6; e290106158232525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/15823/14103Copyright (c) 2021 Suzana Alves Mundim Carneiro; Isabella Tavares Souza ; Raika Eduarda Rodrigues da Silva ; Emerith Mayra Hungria Pinto; Aline de Araújo Freitashttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarneiro, Suzana Alves Mundim Souza , Isabella Tavares Silva , Raika Eduarda Rodrigues daPinto, Emerith Mayra Hungria Freitas, Aline de Araújo 2021-06-10T22:51:46Zoai:ojs.pkp.sfu.ca:article/15823Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:36:33.972353Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
Lesión neural hansénica: Papel de la neurotrofina NGF y la citoquina TNFα
Lesão neural hansênica: Papel da neurotrofina NGF e da citocina TNFα
title Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
spellingShingle Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
Carneiro, Suzana Alves Mundim
Reação hansênica
Fator de crescimento neural (NGF)
Fator de necrose tumoral alfa (TNF).
Reacción a la lepra
Factor de crescimento neural (NGF)
Factor de necrosis tumoral alfa (TNF).
Leprosy reaction
Nerve growth factor (NGF)
Tumor necrosis factor- alpha (TNFα).
title_short Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
title_full Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
title_fullStr Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
title_full_unstemmed Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
title_sort Neural injury in leprosy: Role of neurotrofin NGF and cytokine TNFα
author Carneiro, Suzana Alves Mundim
author_facet Carneiro, Suzana Alves Mundim
Souza , Isabella Tavares
Silva , Raika Eduarda Rodrigues da
Pinto, Emerith Mayra Hungria
Freitas, Aline de Araújo
author_role author
author2 Souza , Isabella Tavares
Silva , Raika Eduarda Rodrigues da
Pinto, Emerith Mayra Hungria
Freitas, Aline de Araújo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carneiro, Suzana Alves Mundim
Souza , Isabella Tavares
Silva , Raika Eduarda Rodrigues da
Pinto, Emerith Mayra Hungria
Freitas, Aline de Araújo
dc.subject.por.fl_str_mv Reação hansênica
Fator de crescimento neural (NGF)
Fator de necrose tumoral alfa (TNF).
Reacción a la lepra
Factor de crescimento neural (NGF)
Factor de necrosis tumoral alfa (TNF).
Leprosy reaction
Nerve growth factor (NGF)
Tumor necrosis factor- alpha (TNFα).
topic Reação hansênica
Fator de crescimento neural (NGF)
Fator de necrose tumoral alfa (TNF).
Reacción a la lepra
Factor de crescimento neural (NGF)
Factor de necrosis tumoral alfa (TNF).
Leprosy reaction
Nerve growth factor (NGF)
Tumor necrosis factor- alpha (TNFα).
description The immunopathological mechanisms involved in the development of leprosy neural injury are not yet fully understood. Thus, the objective of this study was to perform an integrative review in order to identify the involvement of neurotrophin NGF and cytokine TNFα in the pathogenesis of neural injury in leprosy reactions. This review was carried out by search for scientific articles in the databases PubMed, SciELO and Google Acadêmico following the Descriptors of Health Science (DeCS) “Leprosy Reaction”, “Nerve Growth Factor (NGF)”, “Tumor Necrosis Factor- alpha (TNFα)”, and 28 articles was selected. The results showed that in the type 1 reaction there is tissue expression of IL-2, IFNg, TNFα, IL-12 and IL-1b. Whereas the type 2 or ENH reaction has been associated with high TNFα concentrations, neutrophilic infiltration and activation of complement system. High levels of NGF were observed in the lepromatous form of the disease and, low levels, in the tuberculoid form, since this stimulates the expression of TNFα, contributing to the evolution of neural lesions. There seems to be an interaction between NGF and TNFα, since NGF induces endogenous expression of TNFα and this positive feedback promotes a survival of healthy neural cells.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15823
10.33448/rsd-v10i6.15823
url https://rsdjournal.org/index.php/rsd/article/view/15823
identifier_str_mv 10.33448/rsd-v10i6.15823
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/15823/14103
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 6; e29010615823
Research, Society and Development; Vol. 10 Núm. 6; e29010615823
Research, Society and Development; v. 10 n. 6; e29010615823
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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