Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion

Detalhes bibliográficos
Autor(a) principal: Goes, Paulo Roberto Nunes de
Data de Publicação: 2020
Outros Autores: Hoscheid, Jaqueline, Silva-Filho, Saulo Euclides, Froehlich, Diego Lacir, Pelegrini, Bruna Luíza, Canoff, Jéssica Renata de Almeida, Lima, Marli Miriam de Souza, Cuman, Roberto Kenji Nakamura, Cardoso, Mara Lane Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/8119
Resumo: Pterodon pubescens, popularly known as "sucupira", it is traditionally used as anti-inflammatory agent. This work aimed to evaluate the in vivo antiarthritic properties of a P. pubescens oil nanoemulsion and the rheological behavior of the developed system. The viscoelastic properties, creep and recovery were evaluated by dynamic oscillatory tests. The antiarthritic activity of the nanoemulsion was evaluated by the zymozan-induced arthritis model, at three different doses (25, 50 and 125 mg/kg/day). P. pubescens oil nanoemulsion has been shown to decrease cell recruitment to a joint cavity and increased cartilaginous regeneration at the end of treatment of the dose of 50 mg/kg. The evaluation of the behaviour of deformation allowed to observe that the P. pubescens nanoemulsion presents predominantly elastic characteristic. These findings demonstrate the potential of P. pubescens and nanotechnology in the development of new antiarthritic drugs.
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spelling Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion Comportamiento reológico y actividad antiartrítica de la nanoemulsión de Pterodon pubescensComportamento reológico e atividade antiartrítica da nanoemulsão de Pterodon pubescensAntiarthritic activityCreep and RecoverySucupiraViscoelasticity.Actividad antiartríticaFluidez y recuperaciónSucupiraViscoelasticidad.Atividade antiartríticaFluência e recuperaçãoSucupiraViscoelasticidade.Pterodon pubescens, popularly known as "sucupira", it is traditionally used as anti-inflammatory agent. This work aimed to evaluate the in vivo antiarthritic properties of a P. pubescens oil nanoemulsion and the rheological behavior of the developed system. The viscoelastic properties, creep and recovery were evaluated by dynamic oscillatory tests. The antiarthritic activity of the nanoemulsion was evaluated by the zymozan-induced arthritis model, at three different doses (25, 50 and 125 mg/kg/day). P. pubescens oil nanoemulsion has been shown to decrease cell recruitment to a joint cavity and increased cartilaginous regeneration at the end of treatment of the dose of 50 mg/kg. The evaluation of the behaviour of deformation allowed to observe that the P. pubescens nanoemulsion presents predominantly elastic characteristic. These findings demonstrate the potential of P. pubescens and nanotechnology in the development of new antiarthritic drugs.Pterodon pubescens, conocido popularmente como "sucupira", se usa tradicionalmente como antiinflamatorio. Este trabajo tuvo como objetivo evaluar las propiedades antiartríticas in vivo de una nanoemulsión que contiene lo aceite de P. pubescens y el comportamiento reológico del sistema desarrollado. Las propiedades viscoelásticas, fluencia y recuperación se evaluaron mediante ensayos oscilatorios dinámicos. La actividad antiartrítica de la nanoemulsión se evaluó mediante el modelo de artritis inducida por zimozan, en tres concentraciones diferentes (25, 50 y 125 mg/kg/día). Se ha demostrado que la nanoemulsión que contiene aceite de P. pubescens en la dosis de 50 mg/kg disminuye el reclutamiento de células a la cavidad articular y aumenta la regeneración del cartílago al final del tratamiento. La evaluación del comportamiento de deformación permitió observar que la nanoemulsión de P. pubescens tiene una característica predominantemente elástica. Estos hallazgos demuestran el potencial del uso de P. pubescens en nanotecnología para el desarrollo de nuevos fármacos antiartríticos.Pterodon pubescens, popularmente conhecido como "sucupira", é tradicionalmente utilizado como anti-inflamatório. Este trabalho teve o objetivo de avaliar as propriedades antiartríticas in vivo de uma nanoemulsão contendo o óleo de P. pubescens e o comportamento reológico do sistema desenvolvido. As propriedades viscoelásticas, fluência e recuperação foram avaliadas por testes oscilatórios dinâmicos. A atividade antiartrítica da nanoemulsão foi avaliada pelo modelo de artrite induzida por zimozan, em três diferentes concentrações (25, 50 e 125 mg/kg/dia). Demonstrou-se que a nanoemulsão contendo o óleo de P. pubescens na dose de 50 mg/kg diminui o recrutamento de células para uma cavidade articular e aumenta a regeneração cartilaginosa no final do tratamento. A avaliação do comportamento de deformação permitiu observar que a nanoemulsão de P. pubescens apresenta característica predominantemente elástica. Esses achados demonstram o potencial da aplicação de P. pubescens na nanotecnologia para o desenvolvimento de novos medicamentos antiartríticos.Research, Society and Development2020-09-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/811910.33448/rsd-v9i10.8119Research, Society and Development; Vol. 9 No. 10; e179108119Research, Society and Development; Vol. 9 Núm. 10; e179108119Research, Society and Development; v. 9 n. 10; e1791081192525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/8119/7312Copyright (c) 2020 Paulo Roberto Nunes de Goes; Jaqueline Hoscheid; Saulo Euclides Silva-Filho; Diego Lacir Froehlich; Bruna Luíza Pelegrini; Jéssica Renata de Almeida Canoff; Marli Miriam de Souza Lima; Roberto Kenji Nakamura Cuman; Mara Lane Carvalho Cardosohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGoes, Paulo Roberto Nunes deHoscheid, JaquelineSilva-Filho, Saulo EuclidesFroehlich, Diego Lacir Pelegrini, Bruna Luíza Canoff, Jéssica Renata de Almeida Lima, Marli Miriam de Souza Cuman, Roberto Kenji Nakamura Cardoso, Mara Lane Carvalho2020-10-31T12:03:23Zoai:ojs.pkp.sfu.ca:article/8119Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:40.222418Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
Comportamiento reológico y actividad antiartrítica de la nanoemulsión de Pterodon pubescens
Comportamento reológico e atividade antiartrítica da nanoemulsão de Pterodon pubescens
title Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
spellingShingle Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
Goes, Paulo Roberto Nunes de
Antiarthritic activity
Creep and Recovery
Sucupira
Viscoelasticity.
Actividad antiartrítica
Fluidez y recuperación
Sucupira
Viscoelasticidad.
Atividade antiartrítica
Fluência e recuperação
Sucupira
Viscoelasticidade.
title_short Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
title_full Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
title_fullStr Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
title_full_unstemmed Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
title_sort Rheological behavior and antiarthritic activity of Pterodon pubescens nanoemulsion
author Goes, Paulo Roberto Nunes de
author_facet Goes, Paulo Roberto Nunes de
Hoscheid, Jaqueline
Silva-Filho, Saulo Euclides
Froehlich, Diego Lacir
Pelegrini, Bruna Luíza
Canoff, Jéssica Renata de Almeida
Lima, Marli Miriam de Souza
Cuman, Roberto Kenji Nakamura
Cardoso, Mara Lane Carvalho
author_role author
author2 Hoscheid, Jaqueline
Silva-Filho, Saulo Euclides
Froehlich, Diego Lacir
Pelegrini, Bruna Luíza
Canoff, Jéssica Renata de Almeida
Lima, Marli Miriam de Souza
Cuman, Roberto Kenji Nakamura
Cardoso, Mara Lane Carvalho
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Goes, Paulo Roberto Nunes de
Hoscheid, Jaqueline
Silva-Filho, Saulo Euclides
Froehlich, Diego Lacir
Pelegrini, Bruna Luíza
Canoff, Jéssica Renata de Almeida
Lima, Marli Miriam de Souza
Cuman, Roberto Kenji Nakamura
Cardoso, Mara Lane Carvalho
dc.subject.por.fl_str_mv Antiarthritic activity
Creep and Recovery
Sucupira
Viscoelasticity.
Actividad antiartrítica
Fluidez y recuperación
Sucupira
Viscoelasticidad.
Atividade antiartrítica
Fluência e recuperação
Sucupira
Viscoelasticidade.
topic Antiarthritic activity
Creep and Recovery
Sucupira
Viscoelasticity.
Actividad antiartrítica
Fluidez y recuperación
Sucupira
Viscoelasticidad.
Atividade antiartrítica
Fluência e recuperação
Sucupira
Viscoelasticidade.
description Pterodon pubescens, popularly known as "sucupira", it is traditionally used as anti-inflammatory agent. This work aimed to evaluate the in vivo antiarthritic properties of a P. pubescens oil nanoemulsion and the rheological behavior of the developed system. The viscoelastic properties, creep and recovery were evaluated by dynamic oscillatory tests. The antiarthritic activity of the nanoemulsion was evaluated by the zymozan-induced arthritis model, at three different doses (25, 50 and 125 mg/kg/day). P. pubescens oil nanoemulsion has been shown to decrease cell recruitment to a joint cavity and increased cartilaginous regeneration at the end of treatment of the dose of 50 mg/kg. The evaluation of the behaviour of deformation allowed to observe that the P. pubescens nanoemulsion presents predominantly elastic characteristic. These findings demonstrate the potential of P. pubescens and nanotechnology in the development of new antiarthritic drugs.
publishDate 2020
dc.date.none.fl_str_mv 2020-09-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/8119
10.33448/rsd-v9i10.8119
url https://rsdjournal.org/index.php/rsd/article/view/8119
identifier_str_mv 10.33448/rsd-v9i10.8119
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/8119/7312
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 10; e179108119
Research, Society and Development; Vol. 9 Núm. 10; e179108119
Research, Society and Development; v. 9 n. 10; e179108119
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052780558417920

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