Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR)
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/28995 |
Resumo: | Background: Juçara açaí is a Brazilian berry with high anthocyanidin content and high antioxidant properties. A correlation between oxidative stress, hypertension and baroreflex impairment is known, however, no previous studies investigate the effect of juçara fruit pulp on hypertension. Aim: The aim of this study was to investigate antihypertensive effect of juçara (Euterpe edulis) fruit pulp in SHR animals, its antioxidant capacity and influence on baroreflex sensitivity. Methods: Chemical profile was obtained by ESI(-)-FT-ICR-MS. For biological analysis, male SHR were separated into groups: control (S), which received water; captopril (SC), which received captopril (30 mg/kg), and juçara (SJ), which received juçara pulp (4.4mL/kg). Treatments were daily performed by gavage and remained for 8 weeks. Baroreflex evaluation was made by in bolus injection of phenylephrine and sodium nitroprusside, after the analysis the heart was frozen (-80ºC) for biomolecular evaluations (AOPP, TBARS, SOD and catalase activity and protein expression). Results: The treatments promoted decrease in arterial pressure (S: 163.3±2.2; SC: 154.0±0.6; SJ: 149.0±3.8 mmHg) and improved the baroreflex sensitivity after nitroprusside activation. In addition, it promoted a decrease in AOPP and an increase in the activity of antioxidant enzymes. However, no changes were observed in protein expression. Conclusion: It was shown that juçara can promote cardiovascular benefits and its consume should be stimulated for prevention of hypertension. |
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Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR)El tratamiento crónico con extracto de fruta de juçara (Euterpe edulis) produce un efecto antihipertensivo y mejora la sensibilidad barorrefleja en ratas hipertensas espontâneas (SHR)Tratamento crônico com polpa do fruto de juçara (Euterpe edulis) produz efeito anti-hipertensivo e melhora a sensibilidade do barorreflexo em ratos espontaneamente hipertensos (SHR)AntocianidinasAntihipertensivoAntioxidanteAçaí de la Mata AtlánticaControl de la presión arterialControl de la presión refleja.AnthocyanidinsAtlantic açaíBlood pressure controlAntihypertensiveAntioxidantReflex pressure control.Antocianidinas Anti-hipertensivo AntioxidanteAçaí da Mata atlânticaControle da pressão arterialControle reflexo da pressão.Background: Juçara açaí is a Brazilian berry with high anthocyanidin content and high antioxidant properties. A correlation between oxidative stress, hypertension and baroreflex impairment is known, however, no previous studies investigate the effect of juçara fruit pulp on hypertension. Aim: The aim of this study was to investigate antihypertensive effect of juçara (Euterpe edulis) fruit pulp in SHR animals, its antioxidant capacity and influence on baroreflex sensitivity. Methods: Chemical profile was obtained by ESI(-)-FT-ICR-MS. For biological analysis, male SHR were separated into groups: control (S), which received water; captopril (SC), which received captopril (30 mg/kg), and juçara (SJ), which received juçara pulp (4.4mL/kg). Treatments were daily performed by gavage and remained for 8 weeks. Baroreflex evaluation was made by in bolus injection of phenylephrine and sodium nitroprusside, after the analysis the heart was frozen (-80ºC) for biomolecular evaluations (AOPP, TBARS, SOD and catalase activity and protein expression). Results: The treatments promoted decrease in arterial pressure (S: 163.3±2.2; SC: 154.0±0.6; SJ: 149.0±3.8 mmHg) and improved the baroreflex sensitivity after nitroprusside activation. In addition, it promoted a decrease in AOPP and an increase in the activity of antioxidant enzymes. However, no changes were observed in protein expression. Conclusion: It was shown that juçara can promote cardiovascular benefits and its consume should be stimulated for prevention of hypertension.Introducción: Juçara açaí es una fruta brasileña con alta concentración de antocianidinas y excelentes propiedades antioxidantes. La correlación entre el estrés oxidativo, la hipertensión y el daño barorreflejo es conocido, sin embargo, los estudios previos que investigan el efecto de la pulpa de juçara en la hipertensión son escasos. Objetivo: El objetivo del presente estudio es investigar el efecto antihipertensivo de la pulpa del fruto de juçara (Euterpe edulis) en animales SHR, su capacidad antioxidante y la influencia del tratamiento en la sensibilidad barorrefleja. Metodología: El perfil químico se obtuvo por ESI(-)-FT-ICR-MS. Para los análisis biológicos, las ratas macho SHR se separaron en grupos: control (S) que recibió agua; captopril (SC) que recibió captopril (30 mg/kg) y el grupo juçara (SJ) que recibió pulpa de juçara (4,4 mL/kg). Todos los tratamientos se realizaron diariamente por vía oral (gavage) y se mantuvieron durante 8 semanas. La evaluación del barorreflejo se realizó mediante inyección en bolo de fenilefrina y nitroprusiato de sodio, y después del análisis hemodinámico, los corazones se recolectaron y congelaron (-80ºC) para análisis biomolecular (AOPP, TBARS, SOD y actividad de catalasa y expresión de proteínas). Resultados: Los tratamientos promovieron una reducción de la presión arterial (S: 163,3±2,2; SC: 154,0±0,6; SJ: 149,0±3,8 mmHg) y mejoraron la sensibilidad barorrefleja después de la activación con nitroprusiato de sodio. Además, se observó una reducción en los niveles de AOPP y un aumento en la actividad de las enzimas antioxidantes. Sin embargo, no se observaron cambios en la expresión de proteínas. Conclusión: Nuestros datos demuestran que la juçara puede promover beneficios cardiovasculares y se debe fomentar su consumo para prevenir la hipertensión arterial.Introdução: O açaí juçara é uma fruta brasileira com alta concentração de antocianidinas e excelente propriedade antioxidante. A correlação entre estresse oxidativo, hipertensão e prejuízo no barorreflexo é conhecida, porém, estudos prévios investigando o efeito da polpa de juçara na hipertensão são escassos. Objetivo: O objetivo do presente estudo é investigar o efeito anti-hipertensivo da polpa do fruto de juçara (Euterpe edulis) em animais SHR, sua capacidade antioxidante e a influência do tratamento na sensibilidade do barorreflexo. Metodologia: O perfil químico foi obtido por ESI(-)-FT-ICR-MS. Para as análises biológicas, os ratos SHR machos foram separados em grupos: controle (S) que recebeu água; captopril (SC) que recebeu captopril (30 mg/kg) e o grupo juçara (SJ) que recebeu a polpa de juçara (4,4 mL/kg). Todos os tratamentos foram realizados diariamente por via oral (gavagem) e mantidos por 8 semanas. A avaliação do barorreflexo foi feita pela injeção in bolus de fenilefrina e nitroprussiato de sódio, e após as análises hemodinâmicas, os corações foram coletados e congelados (-80ºC) para as análises biomoleculares (AOPP, TBARS, atividade da SOD e catalase e expressão proteica). Resultados: Os tratamentos promoveram redução na pressão arterial (S: 163,3±2,2; SC: 154,0±0,6; SJ: 149,0±3,8 mmHg) e melhoraram a sensibilidade do barorreflexo após a ativação com o nitroprussiato de sódio. Adicionalmente, foi observado redução nos níveis de AOPP e aumento da atividade das enzimas antioxidantes. Entretanto, não foram observadas mudanças na expressão proteica. Conclusão: Nossos dados demonstram que a juçara pode promover benefícios cardiovasculares e o seu consumo deve ser estimulado para a prevenção da hipertensão arterial.Research, Society and Development2022-05-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2899510.33448/rsd-v11i7.28995Research, Society and Development; Vol. 11 No. 7; e5711728995Research, Society and Development; Vol. 11 Núm. 7; e5711728995Research, Society and Development; v. 11 n. 7; e57117289952525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/28995/25620Copyright (c) 2022 Augusto Altoé Puppin; Cristiane Lyrio da Silva; Silas Nascimento Ronchi; Mirian de Almeida Silva; Ewelyne Miranda de Lima; Bruno Gomes de Oliveira; Wanderson Romão; Nazaré Souza Bissoli; Tadeu Uggere de Andrade; Denise Coutinho Endringer; Girlandia Alexandre Brasilhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPuppin, Augusto Altoé Silva, Cristiane Lyrio da Ronchi, Silas Nascimento Silva, Mirian de Almeida Lima, Ewelyne Miranda de Oliveira, Bruno Gomes de Romão, WandersonBissoli, Nazaré Souza Andrade, Tadeu Uggere de Endringer, Denise Coutinho Brasil, Girlandia Alexandre 2022-06-06T15:12:05Zoai:ojs.pkp.sfu.ca:article/28995Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:46:12.127460Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) El tratamiento crónico con extracto de fruta de juçara (Euterpe edulis) produce un efecto antihipertensivo y mejora la sensibilidad barorrefleja en ratas hipertensas espontâneas (SHR) Tratamento crônico com polpa do fruto de juçara (Euterpe edulis) produz efeito anti-hipertensivo e melhora a sensibilidade do barorreflexo em ratos espontaneamente hipertensos (SHR) |
title |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) |
spellingShingle |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) Puppin, Augusto Altoé Antocianidinas Antihipertensivo Antioxidante Açaí de la Mata Atlántica Control de la presión arterial Control de la presión refleja. Anthocyanidins Atlantic açaí Blood pressure control Antihypertensive Antioxidant Reflex pressure control. Antocianidinas Anti-hipertensivo Antioxidante Açaí da Mata atlântica Controle da pressão arterial Controle reflexo da pressão. |
title_short |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) |
title_full |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) |
title_fullStr |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) |
title_full_unstemmed |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) |
title_sort |
Chronic treatment with juçara (Euterpe edulis) fruit pulp produces antihypertensive effect and improve on baroreflex sensitivity in Spontaneous Hypertensive Rats (SHR) |
author |
Puppin, Augusto Altoé |
author_facet |
Puppin, Augusto Altoé Silva, Cristiane Lyrio da Ronchi, Silas Nascimento Silva, Mirian de Almeida Lima, Ewelyne Miranda de Oliveira, Bruno Gomes de Romão, Wanderson Bissoli, Nazaré Souza Andrade, Tadeu Uggere de Endringer, Denise Coutinho Brasil, Girlandia Alexandre |
author_role |
author |
author2 |
Silva, Cristiane Lyrio da Ronchi, Silas Nascimento Silva, Mirian de Almeida Lima, Ewelyne Miranda de Oliveira, Bruno Gomes de Romão, Wanderson Bissoli, Nazaré Souza Andrade, Tadeu Uggere de Endringer, Denise Coutinho Brasil, Girlandia Alexandre |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Puppin, Augusto Altoé Silva, Cristiane Lyrio da Ronchi, Silas Nascimento Silva, Mirian de Almeida Lima, Ewelyne Miranda de Oliveira, Bruno Gomes de Romão, Wanderson Bissoli, Nazaré Souza Andrade, Tadeu Uggere de Endringer, Denise Coutinho Brasil, Girlandia Alexandre |
dc.subject.por.fl_str_mv |
Antocianidinas Antihipertensivo Antioxidante Açaí de la Mata Atlántica Control de la presión arterial Control de la presión refleja. Anthocyanidins Atlantic açaí Blood pressure control Antihypertensive Antioxidant Reflex pressure control. Antocianidinas Anti-hipertensivo Antioxidante Açaí da Mata atlântica Controle da pressão arterial Controle reflexo da pressão. |
topic |
Antocianidinas Antihipertensivo Antioxidante Açaí de la Mata Atlántica Control de la presión arterial Control de la presión refleja. Anthocyanidins Atlantic açaí Blood pressure control Antihypertensive Antioxidant Reflex pressure control. Antocianidinas Anti-hipertensivo Antioxidante Açaí da Mata atlântica Controle da pressão arterial Controle reflexo da pressão. |
description |
Background: Juçara açaí is a Brazilian berry with high anthocyanidin content and high antioxidant properties. A correlation between oxidative stress, hypertension and baroreflex impairment is known, however, no previous studies investigate the effect of juçara fruit pulp on hypertension. Aim: The aim of this study was to investigate antihypertensive effect of juçara (Euterpe edulis) fruit pulp in SHR animals, its antioxidant capacity and influence on baroreflex sensitivity. Methods: Chemical profile was obtained by ESI(-)-FT-ICR-MS. For biological analysis, male SHR were separated into groups: control (S), which received water; captopril (SC), which received captopril (30 mg/kg), and juçara (SJ), which received juçara pulp (4.4mL/kg). Treatments were daily performed by gavage and remained for 8 weeks. Baroreflex evaluation was made by in bolus injection of phenylephrine and sodium nitroprusside, after the analysis the heart was frozen (-80ºC) for biomolecular evaluations (AOPP, TBARS, SOD and catalase activity and protein expression). Results: The treatments promoted decrease in arterial pressure (S: 163.3±2.2; SC: 154.0±0.6; SJ: 149.0±3.8 mmHg) and improved the baroreflex sensitivity after nitroprusside activation. In addition, it promoted a decrease in AOPP and an increase in the activity of antioxidant enzymes. However, no changes were observed in protein expression. Conclusion: It was shown that juçara can promote cardiovascular benefits and its consume should be stimulated for prevention of hypertension. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/28995 10.33448/rsd-v11i7.28995 |
url |
https://rsdjournal.org/index.php/rsd/article/view/28995 |
identifier_str_mv |
10.33448/rsd-v11i7.28995 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/28995/25620 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 7; e5711728995 Research, Society and Development; Vol. 11 Núm. 7; e5711728995 Research, Society and Development; v. 11 n. 7; e5711728995 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052711255932928 |