Ultrasound-assisted cinnamaldehyde nanoemulsion: optimization of operational variables, colloidal properties and in-vitro antibacterial activity

• Autor(a) principal: Ribeiro, Alane Rafaela Costa
• Data de Publicação: 2022
• Outros Autores: Oliveira, Taíla Veloso de, Baffa Júnior, José Carlos, Bastos, Maria do Socorro Rocha, Batista, Lais Fernanda, Teixeira, Samiris Côcco Teixeira, Soares, Nilda de Fátima Ferreira
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Research, Society and Development
• Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/32115
• topic: Cinamaldeído; Nanoemulsão; Ultrassom; Atividade antibacteriana; Otimização.; Cinnamaldehyde; Nanoemulsion; Ultrasound; Antibacterial Activity; Optimization.; Cinnamaldehído; Nanoemulsión; Ultrasonido; Actividad antibacteriana; Optimización.

Ultrasound-assisted cinnamaldehyde nanoemulsions (CNN) emerge as an energetically viable and potentially promising alternative for the controlled delivery of this bioactive organic compound. This context, the main objective of the study was to optimize the operational variables of the ultrasound-assisted production process of CNN in order to evaluate the effect of operational elements on the kinetic stability, bioactive composition and antibacterial activity of the obtained CNN. Response surface methodology (RSM) via rotational central composite design was used for fitting, when possible, second-order polynomial models. The sonication time (TS) and the amplitude of ultrasonic power (AP) were the studied factors, while the response variables corresponded to the hydrodynamic diameter (DH), the polydispersity index (PDI), the zeta potential (ZP), the turbidity (T) and the total phenolic composition (TCP), respectively. The in-vitro antibacterial activity of the obtained systems was carried out by means of the analytical methodology of diffusion on agar-well. The results showed that regardless of the TS used in the process, the lowest values for the DH and T of the nanoemulsions were obtained under conditions of low amplitude of ultrasonic power. The PDI values revealed that the NNC were monodisperse, with preserved TCP contents during the obtaining process and considerable antibacterial activity. Therefore, it was possible, by means of MSR, to propose the ideal operational conditions during the preparation and thus obtain NNC with physicochemical characteristics that reinforce their high kinetic stability and maintenance of bioactive and antimicrobial composition during processing.