Autophagy and Cancer: a literature review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/7493 |
Resumo: | Autophagia, or macroautophagy, is a phenomenon of cellular degradation and recycling that occurs constitutively at low levels in eukaryotic cells. Thasgained prominence as a pathway of mobilization of metabolic substrates that allow cancer cells to survive microenvironments with low nutrient supply or under conditions of oxidative stress, where the role of proteins such as beclin-1 and LC3B has been widely researched in various types of cancer. The aim of the present study was to review the literature on the performance of the autophagy process and its relationship with the development of cancer through autophagia. To design This article, a bibliographic survey was carried out covering the period from 1998 to 2019. Google academic, Scielo, LIlacs and Medline research portals were used. In this review, it is the result that autophagy has a dual role in cancer, as it can prevent tumor initiation through the suppression of chronic damage, inflammation, accumulation of damaged organelles and genomic instability, but Autophagia also maintains the Mitochondrial metabolic functions that provide nutrients for the growth of tumor cells, creating aggressive cancers. |
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Autophagy and Cancer: a literature reviewAutofagia y cáncer: una revisión de la literaturaAutofagia e Câncer: uma revisão da literaturaAutofagiaNeoplasiasCrecimiento y desarrollo.AutophagyNeoplasmsGrowth and development.AutofagiaCâncerCrescimento e desenvolvimento.Autophagia, or macroautophagy, is a phenomenon of cellular degradation and recycling that occurs constitutively at low levels in eukaryotic cells. Thasgained prominence as a pathway of mobilization of metabolic substrates that allow cancer cells to survive microenvironments with low nutrient supply or under conditions of oxidative stress, where the role of proteins such as beclin-1 and LC3B has been widely researched in various types of cancer. The aim of the present study was to review the literature on the performance of the autophagy process and its relationship with the development of cancer through autophagia. To design This article, a bibliographic survey was carried out covering the period from 1998 to 2019. Google academic, Scielo, LIlacs and Medline research portals were used. In this review, it is the result that autophagy has a dual role in cancer, as it can prevent tumor initiation through the suppression of chronic damage, inflammation, accumulation of damaged organelles and genomic instability, but Autophagia also maintains the Mitochondrial metabolic functions that provide nutrients for the growth of tumor cells, creating aggressive cancers.Introducción: La autofagia, o macroautofagia, es un fenómeno de degradación y reciclaje celular que se produce constitutivamente a niveles bajos en células eucariotas. Ha ganado prominencia como una vía de movilización de sustratos metabólicos que permiten a las células cancerosas sobrevivir a microambientes con bajo suministro de nutrientes o en condiciones de estrés oxidativo, donde el papel de proteínas como Beclin-1 y LC3B ha sido ampliamente investigado en varios tipos de cáncer. Objetivo: El objetivo de este estudio fue revisar la literatura sobre el rendimiento del proceso de autofagia y su relación con el desarrollo del cáncer a través de la autofagia tumoral. Metodología: Para la concepción de este artículo, se llevó a cabo una encuesta bibliográfica que abarca el período comprendido entre 1998 y 2019. Se utilizaron los portales de búsqueda Google Scholar, Scielo, LIlacs y Medline. Resultados y conclusión: Esta revisión resulta en la autofagia como un doble papel en el cáncer porque puede prevenir la iniciación del tumor a través de la supresión del daño crónico, inflamación, acumulación de orgánulos dañados e inestabilidad genómica, pero la autofagia también mantiene funciones metabólicas mitocondriales que proporcionan nutrientes para el crecimiento de las células tumorales, creando cánceres agresivos.Introdução: A autofagia, ou macroautofagia, é um fenômeno de degradação e reciclagem celular que ocorre constitutivamente em baixos níveis nas células eucarióticas. Tem ganhado destaque como via de mobilização de substratos metabólicos que permitem células cancerosas sobreviverem a microambientes com baixa oferta de nutrientes ou em condições de estresse oxidativo, onde o papel de proteínas como o Beclin-1 e LC3B tem sido amplamente pesquisado em diversos tipos de câncer. Objetivo: O objetivo do presente estudo foi fazer uma revisão de literatura acerca da atuação do processo de autofagia e sua relação com o desenvolvimento de câncer através da autofagia tumoral. Metodologia: Para concepção deste artigo foi realizado um levantamento bibliográfico que abrangeu o período de 1998 a 2019. Foram utilizados os portais de pesquisa Google Acadêmico, Scielo, LIlacs e Medline. Resultados e Conclusão: Nesta revisão tem como resultado que a autofagia tem papel dual no câncer pois pode prevenir a iniciação tumoral através da supressão de danos crônicos, inflamação, acúmulo de organelas danificadas e instabilidade genômica, porém a autofagia também mantém as funções metabólicas mitocondriais que fornece nutrientes para o crescimento das células tumorais, criando canceres agressivos.Research, Society and Development2020-08-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/749310.33448/rsd-v9i9.7493Research, Society and Development; Vol. 9 No. 9; e584997493Research, Society and Development; Vol. 9 Núm. 9; e584997493Research, Society and Development; v. 9 n. 9; e5849974932525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/7493/6776Copyright (c) 2020 Gabriel Cortez da Silva; Victor Angelo Martins Montalli; Ney Soares De Araújo ; Vera Cavalcanti De Araújo ; João Augusto Vianna Goulart-Filho https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Gabriel Cortez da Montalli, Victor Angelo Martins Araújo , Ney Soares De Araújo , Vera Cavalcanti De Goulart-Filho , João Augusto Vianna 2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/7493Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:11.855235Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Autophagy and Cancer: a literature review Autofagia y cáncer: una revisión de la literatura Autofagia e Câncer: uma revisão da literatura |
title |
Autophagy and Cancer: a literature review |
spellingShingle |
Autophagy and Cancer: a literature review Silva, Gabriel Cortez da Autofagia Neoplasias Crecimiento y desarrollo. Autophagy Neoplasms Growth and development. Autofagia Câncer Crescimento e desenvolvimento. |
title_short |
Autophagy and Cancer: a literature review |
title_full |
Autophagy and Cancer: a literature review |
title_fullStr |
Autophagy and Cancer: a literature review |
title_full_unstemmed |
Autophagy and Cancer: a literature review |
title_sort |
Autophagy and Cancer: a literature review |
author |
Silva, Gabriel Cortez da |
author_facet |
Silva, Gabriel Cortez da Montalli, Victor Angelo Martins Araújo , Ney Soares De Araújo , Vera Cavalcanti De Goulart-Filho , João Augusto Vianna |
author_role |
author |
author2 |
Montalli, Victor Angelo Martins Araújo , Ney Soares De Araújo , Vera Cavalcanti De Goulart-Filho , João Augusto Vianna |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Silva, Gabriel Cortez da Montalli, Victor Angelo Martins Araújo , Ney Soares De Araújo , Vera Cavalcanti De Goulart-Filho , João Augusto Vianna |
dc.subject.por.fl_str_mv |
Autofagia Neoplasias Crecimiento y desarrollo. Autophagy Neoplasms Growth and development. Autofagia Câncer Crescimento e desenvolvimento. |
topic |
Autofagia Neoplasias Crecimiento y desarrollo. Autophagy Neoplasms Growth and development. Autofagia Câncer Crescimento e desenvolvimento. |
description |
Autophagia, or macroautophagy, is a phenomenon of cellular degradation and recycling that occurs constitutively at low levels in eukaryotic cells. Thasgained prominence as a pathway of mobilization of metabolic substrates that allow cancer cells to survive microenvironments with low nutrient supply or under conditions of oxidative stress, where the role of proteins such as beclin-1 and LC3B has been widely researched in various types of cancer. The aim of the present study was to review the literature on the performance of the autophagy process and its relationship with the development of cancer through autophagia. To design This article, a bibliographic survey was carried out covering the period from 1998 to 2019. Google academic, Scielo, LIlacs and Medline research portals were used. In this review, it is the result that autophagy has a dual role in cancer, as it can prevent tumor initiation through the suppression of chronic damage, inflammation, accumulation of damaged organelles and genomic instability, but Autophagia also maintains the Mitochondrial metabolic functions that provide nutrients for the growth of tumor cells, creating aggressive cancers. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-30 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/7493 10.33448/rsd-v9i9.7493 |
url |
https://rsdjournal.org/index.php/rsd/article/view/7493 |
identifier_str_mv |
10.33448/rsd-v9i9.7493 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/7493/6776 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 9; e584997493 Research, Society and Development; Vol. 9 Núm. 9; e584997493 Research, Society and Development; v. 9 n. 9; e584997493 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052780038324224 |