Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms.
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/24223 |
Resumo: | Objective: To describe the main mechanisms of autophagy stimulated by physical activity and its relationship with the reduction in the incidence of cancer. Material and methods: Data collections were carried out through the analysis of the scientific literature available in the MEDLINE, ScienceDirect and Wiley databases, independently and manually. The terms "cancer", "autophagy" and "physical activity" were used as search descriptors, and the period of time for publications covered the years 1990 to 2020. The inclusion criteria were: "works published within the scope of the study, published in the aforementioned period”. And as an exclusion criterion: “works not related to the study topic and with reports that are already outdated according to current literature”. Results: Physical activity positively influences different systems, leading to acute and chronic changes. The benefits in metabolic, immune, cancerous, cardiovascular, psychiatric and neurological pathologies are indisputable and the mechanisms are being elucidated. Autophagy mediates the digestion and recycling of obsolete cell parts during starvation and participates in a variety of physiological waste removal processes. Autophagy is able to eliminate microorganisms, toxic protein aggregates, genotoxic, playing roles during infection, aging and disease pathogenesis. Conclusion: From the analysis of the mechanisms involved in physical activity-induced autophagy, three main points were postulated: 1) Via mTORC1 inactivated by starvation, 2) Regulation by reactive oxygen species and hypoxia, 3) Regulation of autophagy by alternative pathways to mTORC1. |
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Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms.Influencia de la actividad física en la inducción de la autofagia y la reducción de la incidencia de cáncer: una revision crítica de los mecanismos fisiológicos y metabólicos. Influência da atividade física na indução da autofagia e redução da incidência do câncer: revisão crítica dos mecanismos fisiológicos e metabólicos.AutofagiaExercício físicoPrevenção de doençasCâncer.AutophagyExerciseDisease preventionCancer. AutofagiaEjercicio físicoPrevención de enfermedadesNeoplasias. Objective: To describe the main mechanisms of autophagy stimulated by physical activity and its relationship with the reduction in the incidence of cancer. Material and methods: Data collections were carried out through the analysis of the scientific literature available in the MEDLINE, ScienceDirect and Wiley databases, independently and manually. The terms "cancer", "autophagy" and "physical activity" were used as search descriptors, and the period of time for publications covered the years 1990 to 2020. The inclusion criteria were: "works published within the scope of the study, published in the aforementioned period”. And as an exclusion criterion: “works not related to the study topic and with reports that are already outdated according to current literature”. Results: Physical activity positively influences different systems, leading to acute and chronic changes. The benefits in metabolic, immune, cancerous, cardiovascular, psychiatric and neurological pathologies are indisputable and the mechanisms are being elucidated. Autophagy mediates the digestion and recycling of obsolete cell parts during starvation and participates in a variety of physiological waste removal processes. Autophagy is able to eliminate microorganisms, toxic protein aggregates, genotoxic, playing roles during infection, aging and disease pathogenesis. Conclusion: From the analysis of the mechanisms involved in physical activity-induced autophagy, three main points were postulated: 1) Via mTORC1 inactivated by starvation, 2) Regulation by reactive oxygen species and hypoxia, 3) Regulation of autophagy by alternative pathways to mTORC1.Objetivo: Conocer los principales mecanismos de autofagia descritos por la actividad física y su relación con la reducción de la incidencia de cáncer. Material y métodos: La recogida de datos se realizó mediante el análisis de la literatura científica disponible en las bases de datos MEDLINE, ScienceDirect y Wiley, de forma independiente y manual. Los términos "cáncer", "autofagia" y "actividad física" se utilizaron como descriptores de búsqueda, y el período de tiempo para las publicaciones abarcó los años 1990 a 2020. Los criterios de inclusión fueron: "trabajos publicados en el ámbito del estudio, publicados en el período mencionado”. Y como criterio de exclusión: “trabajos no relacionados con el tema de estudio y con informes que ya están desactualizados según la literatura actual”. Resultados: La actividad física influye positivamente en diferentes sistemas, provocando cambios agudos y crónicos. Los beneficios en patologías metabólicas, inmunitarias, cancerosas, cardiovasculares, psiquiátricas y neurológicas son indiscutibles y los mecanismos se están dilucidando. La autofagia media la digestión y reciclaje de partes celulares obsoletas durante inanición y participa en una variedad de procesos fisiológicos de eliminación de desechos. eliminar microorganismos, agregados proteicos tóxicos, genotóxicos, que juegan roles durante la infección, el envejecimiento y la patogénesis de la enfermedad. Conclusión: A partir del análisis de los mecanismos involucrados en la autofagia inducida por la actividad física, tres puntos principales Se postularon: 1) Vía mTORC1 inactivada por inanición, 2) Regulación por especies reactivas de oxígeno e hipoxia, 3) Regulación de la autofagia por vías alternativas a mTORC1.Objetivo: Descrever os principais mecanismos da autofagia estimulada por atividade física e sua relação com a redução na incidência de câncer. Material e métodos: Foram realizadas coletas de dados através da análise da literatura científica disponível nas bases de dados da MEDLINE, ScienceDirect e Wiley, de maneira independente e manual. Foram utilizados como descritores de busca os termos: “cancer”, “autophagy” e “physical activity”, e o período de tempo para as publicações compreendeu os anos de 1990 a 2020. O critério de inclusão foi: “trabalhos publicados dentro do escopo do estudo, publicados no intervalo de tempo citado”. E como critério de exclusão: “trabalhos não relacionados ao tema de estudo e com relatos já ultrapassados de acordo com a literatura atual”. Resultados: A atividade física influência positivamente diversos sistemas, levando a alterações agudas e crônicas. Os benefícios em patologias metabólicas, imunes, cancerígenas, cardiovasculares, psiquiátricas e neurológicas são indiscutíveis e os mecanismos estão sendo elucidados. Autofagia medeia a digestão e reciclagem de partes obsoletas da célula durante a inanição e participa de uma variedade de processos fisiológicos de remoção residual. A autofagia é capaz de eliminar as microorganimos, agregados proteicos tóxicos, genotóxicos, desempenhando papéis durante a infecção, envelhecimento e patogênese de doenças. Conclusão: A partir da análise dos mecanismos envolvidos na autofagia induzida por atividade física ficaram postulados três pontos principais: 1) Via mTORC1 inativada por inanição, 2) Regulação por espécies reativas de oxigênio e hipóxia, 3) Regulação da autofagia por vias alternativas à mTORC1.Research, Society and Development2021-12-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2422310.33448/rsd-v10i16.24223Research, Society and Development; Vol. 10 No. 16; e441101624223Research, Society and Development; Vol. 10 Núm. 16; e441101624223Research, Society and Development; v. 10 n. 16; e4411016242232525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/24223/21077Copyright (c) 2021 Wesley Gabriel Novaes Botelho; Alcântara Ramos de Assis César; Kádima Nayara Teixeira https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBotelho, Wesley Gabriel Novaes César, Alcântara Ramos de Assis Teixeira , Kádima Nayara 2021-12-20T11:03:07Zoai:ojs.pkp.sfu.ca:article/24223Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:42:51.508598Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. Influencia de la actividad física en la inducción de la autofagia y la reducción de la incidencia de cáncer: una revision crítica de los mecanismos fisiológicos y metabólicos. Influência da atividade física na indução da autofagia e redução da incidência do câncer: revisão crítica dos mecanismos fisiológicos e metabólicos. |
title |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. |
spellingShingle |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. Botelho, Wesley Gabriel Novaes Autofagia Exercício físico Prevenção de doenças Câncer. Autophagy Exercise Disease prevention Cancer. Autofagia Ejercicio físico Prevención de enfermedades Neoplasias. |
title_short |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. |
title_full |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. |
title_fullStr |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. |
title_full_unstemmed |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. |
title_sort |
Influence of physical activity on autophagy inducing and reduction of cancer incidence: critical review of physiological and metabolic mechanisms. |
author |
Botelho, Wesley Gabriel Novaes |
author_facet |
Botelho, Wesley Gabriel Novaes César, Alcântara Ramos de Assis Teixeira , Kádima Nayara |
author_role |
author |
author2 |
César, Alcântara Ramos de Assis Teixeira , Kádima Nayara |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Botelho, Wesley Gabriel Novaes César, Alcântara Ramos de Assis Teixeira , Kádima Nayara |
dc.subject.por.fl_str_mv |
Autofagia Exercício físico Prevenção de doenças Câncer. Autophagy Exercise Disease prevention Cancer. Autofagia Ejercicio físico Prevención de enfermedades Neoplasias. |
topic |
Autofagia Exercício físico Prevenção de doenças Câncer. Autophagy Exercise Disease prevention Cancer. Autofagia Ejercicio físico Prevención de enfermedades Neoplasias. |
description |
Objective: To describe the main mechanisms of autophagy stimulated by physical activity and its relationship with the reduction in the incidence of cancer. Material and methods: Data collections were carried out through the analysis of the scientific literature available in the MEDLINE, ScienceDirect and Wiley databases, independently and manually. The terms "cancer", "autophagy" and "physical activity" were used as search descriptors, and the period of time for publications covered the years 1990 to 2020. The inclusion criteria were: "works published within the scope of the study, published in the aforementioned period”. And as an exclusion criterion: “works not related to the study topic and with reports that are already outdated according to current literature”. Results: Physical activity positively influences different systems, leading to acute and chronic changes. The benefits in metabolic, immune, cancerous, cardiovascular, psychiatric and neurological pathologies are indisputable and the mechanisms are being elucidated. Autophagy mediates the digestion and recycling of obsolete cell parts during starvation and participates in a variety of physiological waste removal processes. Autophagy is able to eliminate microorganisms, toxic protein aggregates, genotoxic, playing roles during infection, aging and disease pathogenesis. Conclusion: From the analysis of the mechanisms involved in physical activity-induced autophagy, three main points were postulated: 1) Via mTORC1 inactivated by starvation, 2) Regulation by reactive oxygen species and hypoxia, 3) Regulation of autophagy by alternative pathways to mTORC1. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/24223 10.33448/rsd-v10i16.24223 |
url |
https://rsdjournal.org/index.php/rsd/article/view/24223 |
identifier_str_mv |
10.33448/rsd-v10i16.24223 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/24223/21077 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 16; e441101624223 Research, Society and Development; Vol. 10 Núm. 16; e441101624223 Research, Society and Development; v. 10 n. 16; e441101624223 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052760244355072 |