Prevention of sepsis in patients with impaired splenic function
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/43583 |
Resumo: | Asplenia refers to the complete loss of spleen function, while hyposplenism refers to the partial loss of splenic function, which may be of primary or secondary origin. The spleen is a secondary lymphoid organ, however, it is also connected with blood circulation. This organ houses a variety of cells, such as T and B lymphocytes, macrophages, dendritic cells, cytokines and antibodies essential for the development of immune responses. In this context, sepsis represents a risk for this group of patients and should be avoided with prophylactic measures, with the majority of infections being caused by encapsulated bacteria. To this end, a literature review was prepared with the main evidence on the prevention of sepsis in patients with asplenia/hyposplenia, using 17 materials from the SciELO, PubMed, Web of Science, Scopus, Cochrane Database of Systematic Reviews (CDSR) databases, EBSCOhost, Virtual Health Library (VHL) and UpToDate. Prevention of sepsis in patients with asplenia or hyposplenia has been shown to involve a combination of vaccination, antibiotic prophylaxis, patient education, and appropriate medical monitoring. It is essential that patients follow medical advice and are aware of the risks and preventive measures necessary to protect their health. Due to the lifelong risk associated with infection in these patients, efforts are focused on improving the quality of care provided to children and adults with restricted splenic function, in addition to ongoing research aimed at alternatives for preventing and treating this condition. |
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Prevention of sepsis in patients with impaired splenic functionPrevención de la sepsis en pacientes con función esplénica alteradaPrevenção de sepse em pacientes com função esplênica prejudicadaAspleniaHipospleniaSepseProfilaxia.AspleniaHypospleniaSepsisProphylaxis.AspleniaHipospleniaSepticemiaProfilaxis.Asplenia refers to the complete loss of spleen function, while hyposplenism refers to the partial loss of splenic function, which may be of primary or secondary origin. The spleen is a secondary lymphoid organ, however, it is also connected with blood circulation. This organ houses a variety of cells, such as T and B lymphocytes, macrophages, dendritic cells, cytokines and antibodies essential for the development of immune responses. In this context, sepsis represents a risk for this group of patients and should be avoided with prophylactic measures, with the majority of infections being caused by encapsulated bacteria. To this end, a literature review was prepared with the main evidence on the prevention of sepsis in patients with asplenia/hyposplenia, using 17 materials from the SciELO, PubMed, Web of Science, Scopus, Cochrane Database of Systematic Reviews (CDSR) databases, EBSCOhost, Virtual Health Library (VHL) and UpToDate. Prevention of sepsis in patients with asplenia or hyposplenia has been shown to involve a combination of vaccination, antibiotic prophylaxis, patient education, and appropriate medical monitoring. It is essential that patients follow medical advice and are aware of the risks and preventive measures necessary to protect their health. Due to the lifelong risk associated with infection in these patients, efforts are focused on improving the quality of care provided to children and adults with restricted splenic function, in addition to ongoing research aimed at alternatives for preventing and treating this condition.La asplenia se refiere a la pérdida completa de la función del bazo, mientras que el hipoesplenismo se refiere a la pérdida parcial de la función esplénica, que puede ser de origen primario o secundario. El bazo es un órgano linfoide secundario, pero también está relacionado con la circulación sanguínea. Este órgano alberga una variedad de células, como linfocitos T y B, macrófagos, células dendríticas, citoquinas y anticuerpos esenciales para el desarrollo de respuestas inmunes. En este contexto, la sepsis representa un riesgo para este grupo de pacientes y debe evitarse con medidas profilácticas, siendo la mayoría de las infecciones causadas por bacterias encapsuladas. Para ello, se elaboró una revisión de la literatura con las principales evidencias sobre la prevención de la sepsis en pacientes con asplenia/hiposplenia, utilizando 17 materiales de las bases de datos SciELO, PubMed, Web of Science, Scopus, Cochrane Database of Systematic Reviews (CDSR), EBSCOhost, Biblioteca Virtual en Salud (BVS) y UpToDate. Se ha demostrado que la prevención de la sepsis en pacientes con asplenia o hiposplenia implica una combinación de vacunación, profilaxis antibiótica, educación del paciente y seguimiento médico adecuado. Es fundamental que los pacientes sigan los consejos médicos y sean conscientes de los riesgos y las medidas preventivas necesarias para proteger su salud. Debido al riesgo de por vida asociado con la infección en estos pacientes, los esfuerzos se centran en mejorar la calidad de la atención brindada a niños y adultos con función esplénica restringida, además de investigaciones en curso dirigidas a alternativas para prevenir y tratar esta condición.Asplenia refere-se à perda completa da função do baço, enquanto hipoesplenismo refere-se à perda parcial da função esplênica, que pode ser de origem primária ou secundária. O baço é um órgão linfóide secundário, porém também está relacionado à circulação sanguínea. Este órgão abriga uma variedade de células, como linfócitos T e B, macrófagos, células dendríticas, citocinas e anticorpos essenciais para o desenvolvimento de respostas imunes. Neste contexto, a sepse representa um risco para este grupo de pacientes e deve ser evitada com medidas profiláticas, sendo a maioria das infecções causadas por bactérias encapsuladas. Para tanto, foi elaborada uma revisão de literatura com as principais evidências sobre a prevenção da sepse em pacientes com asplenia/hiposplenia, utilizando 17 materiais das bases de dados SciELO, PubMed, Web of Science, Scopus, Cochrane Database of Systematic Reviews (CDSR), EBSCOhost, Biblioteca Virtual em Saúde (BVS) e UpToDate. Foi demonstrado que a prevenção da sepse em pacientes com asplenia ou hiposplenia envolve uma combinação de vacinação, profilaxia antibiótica, educação do paciente e monitoramento médico apropriado. É essencial que os pacientes sigam as orientações médicas e estejam cientes dos riscos e das medidas preventivas necessárias para proteger a sua saúde. Devido ao risco vitalício associado à infecção nesses pacientes, os esforços estão focados na melhoria da qualidade do atendimento prestado a crianças e adultos com função esplênica restrita, além de pesquisas em andamento visando alternativas de prevenção e tratamento dessa condição.Research, Society and Development2023-10-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4358310.33448/rsd-v12i10.43583Research, Society and Development; Vol. 12 No. 10; e118121043583Research, Society and Development; Vol. 12 Núm. 10; e118121043583Research, Society and Development; v. 12 n. 10; e1181210435832525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/43583/35034Copyright (c) 2023 Manoel Guedes de Almeida; Débora Regina Marques Barbosahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAlmeida, Manoel Guedes de Barbosa, Débora Regina Marques2023-10-20T10:57:42Zoai:ojs.pkp.sfu.ca:article/43583Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-10-20T10:57:42Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Prevention of sepsis in patients with impaired splenic function Prevención de la sepsis en pacientes con función esplénica alterada Prevenção de sepse em pacientes com função esplênica prejudicada |
title |
Prevention of sepsis in patients with impaired splenic function |
spellingShingle |
Prevention of sepsis in patients with impaired splenic function Almeida, Manoel Guedes de Asplenia Hiposplenia Sepse Profilaxia. Asplenia Hyposplenia Sepsis Prophylaxis. Asplenia Hiposplenia Septicemia Profilaxis. |
title_short |
Prevention of sepsis in patients with impaired splenic function |
title_full |
Prevention of sepsis in patients with impaired splenic function |
title_fullStr |
Prevention of sepsis in patients with impaired splenic function |
title_full_unstemmed |
Prevention of sepsis in patients with impaired splenic function |
title_sort |
Prevention of sepsis in patients with impaired splenic function |
author |
Almeida, Manoel Guedes de |
author_facet |
Almeida, Manoel Guedes de Barbosa, Débora Regina Marques |
author_role |
author |
author2 |
Barbosa, Débora Regina Marques |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Almeida, Manoel Guedes de Barbosa, Débora Regina Marques |
dc.subject.por.fl_str_mv |
Asplenia Hiposplenia Sepse Profilaxia. Asplenia Hyposplenia Sepsis Prophylaxis. Asplenia Hiposplenia Septicemia Profilaxis. |
topic |
Asplenia Hiposplenia Sepse Profilaxia. Asplenia Hyposplenia Sepsis Prophylaxis. Asplenia Hiposplenia Septicemia Profilaxis. |
description |
Asplenia refers to the complete loss of spleen function, while hyposplenism refers to the partial loss of splenic function, which may be of primary or secondary origin. The spleen is a secondary lymphoid organ, however, it is also connected with blood circulation. This organ houses a variety of cells, such as T and B lymphocytes, macrophages, dendritic cells, cytokines and antibodies essential for the development of immune responses. In this context, sepsis represents a risk for this group of patients and should be avoided with prophylactic measures, with the majority of infections being caused by encapsulated bacteria. To this end, a literature review was prepared with the main evidence on the prevention of sepsis in patients with asplenia/hyposplenia, using 17 materials from the SciELO, PubMed, Web of Science, Scopus, Cochrane Database of Systematic Reviews (CDSR) databases, EBSCOhost, Virtual Health Library (VHL) and UpToDate. Prevention of sepsis in patients with asplenia or hyposplenia has been shown to involve a combination of vaccination, antibiotic prophylaxis, patient education, and appropriate medical monitoring. It is essential that patients follow medical advice and are aware of the risks and preventive measures necessary to protect their health. Due to the lifelong risk associated with infection in these patients, efforts are focused on improving the quality of care provided to children and adults with restricted splenic function, in addition to ongoing research aimed at alternatives for preventing and treating this condition. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-16 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/43583 10.33448/rsd-v12i10.43583 |
url |
https://rsdjournal.org/index.php/rsd/article/view/43583 |
identifier_str_mv |
10.33448/rsd-v12i10.43583 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/43583/35034 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Manoel Guedes de Almeida; Débora Regina Marques Barbosa https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Manoel Guedes de Almeida; Débora Regina Marques Barbosa https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 10; e118121043583 Research, Society and Development; Vol. 12 Núm. 10; e118121043583 Research, Society and Development; v. 12 n. 10; e118121043583 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052632318083072 |